<i>Francisella</i> sp., a Close Relative of <i>Francisella orientalis</i>, Causing Septicemia with Cholestatic Hepatitis in a Patient with Anti-Interferon-γ (IFN-γ) Autoantibodies
<i>Francisella</i> is an intracellular, fastidious, Gram-negative bacterium that is difficult to identify using routine microbiological methods in the laboratory. We studied the isolation of <i>Francisella</i> sp. (strain IDAMR664) from the blood of a patient with anti-interf...
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2022-02-01
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author | Rattagan Kajeekul Somchai Insiripong Athita Riwlord Suleeporn Poomchuchit Anusak Kerdsin |
author_facet | Rattagan Kajeekul Somchai Insiripong Athita Riwlord Suleeporn Poomchuchit Anusak Kerdsin |
author_sort | Rattagan Kajeekul |
collection | DOAJ |
description | <i>Francisella</i> is an intracellular, fastidious, Gram-negative bacterium that is difficult to identify using routine microbiological methods in the laboratory. We studied the isolation of <i>Francisella</i> sp. (strain IDAMR664) from the blood of a patient with anti-interferon-γ (IFN-γ) autoantibodies who presented with septicemia and cholestatic hepatitis. Analysis of the strain IDAMR664 genome sequence revealed the isolate was closely related to the strain GA01-2794 that had been isolated from a human in the USA. In addition, it was clustered with <i>F. orientalis</i>, a fish pathogen. The isolate contained several virulence factors and had <i>Francisella</i> pathogenicity island pattern no. 3. |
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spelling | doaj.art-51d3dbb7710442f499a142620832ffeb2023-11-23T22:22:29ZengMDPI AGTropical Medicine and Infectious Disease2414-63662022-02-01722510.3390/tropicalmed7020025<i>Francisella</i> sp., a Close Relative of <i>Francisella orientalis</i>, Causing Septicemia with Cholestatic Hepatitis in a Patient with Anti-Interferon-γ (IFN-γ) AutoantibodiesRattagan Kajeekul0Somchai Insiripong1Athita Riwlord2Suleeporn Poomchuchit3Anusak Kerdsin4Department of Medicine, Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima 30000, ThailandDepartment of Medicine, Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima 30000, ThailandClinical Microbiology Laboratory, Department of Medical Technology, Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima 30000, ThailandDepartment of Community Health, Faculty of Public Health, Chalermphrakiat Sakon Nakhon Province Campus, Kasetsart University, Sakon Nakhon 47000, ThailandDepartment of Community Health, Faculty of Public Health, Chalermphrakiat Sakon Nakhon Province Campus, Kasetsart University, Sakon Nakhon 47000, Thailand<i>Francisella</i> is an intracellular, fastidious, Gram-negative bacterium that is difficult to identify using routine microbiological methods in the laboratory. We studied the isolation of <i>Francisella</i> sp. (strain IDAMR664) from the blood of a patient with anti-interferon-γ (IFN-γ) autoantibodies who presented with septicemia and cholestatic hepatitis. Analysis of the strain IDAMR664 genome sequence revealed the isolate was closely related to the strain GA01-2794 that had been isolated from a human in the USA. In addition, it was clustered with <i>F. orientalis</i>, a fish pathogen. The isolate contained several virulence factors and had <i>Francisella</i> pathogenicity island pattern no. 3.https://www.mdpi.com/2414-6366/7/2/25<i>Francisella philomiragia</i>genomeanti-interferon-γ autoantibodies |
spellingShingle | Rattagan Kajeekul Somchai Insiripong Athita Riwlord Suleeporn Poomchuchit Anusak Kerdsin <i>Francisella</i> sp., a Close Relative of <i>Francisella orientalis</i>, Causing Septicemia with Cholestatic Hepatitis in a Patient with Anti-Interferon-γ (IFN-γ) Autoantibodies Tropical Medicine and Infectious Disease <i>Francisella philomiragia</i> genome anti-interferon-γ autoantibodies |
title | <i>Francisella</i> sp., a Close Relative of <i>Francisella orientalis</i>, Causing Septicemia with Cholestatic Hepatitis in a Patient with Anti-Interferon-γ (IFN-γ) Autoantibodies |
title_full | <i>Francisella</i> sp., a Close Relative of <i>Francisella orientalis</i>, Causing Septicemia with Cholestatic Hepatitis in a Patient with Anti-Interferon-γ (IFN-γ) Autoantibodies |
title_fullStr | <i>Francisella</i> sp., a Close Relative of <i>Francisella orientalis</i>, Causing Septicemia with Cholestatic Hepatitis in a Patient with Anti-Interferon-γ (IFN-γ) Autoantibodies |
title_full_unstemmed | <i>Francisella</i> sp., a Close Relative of <i>Francisella orientalis</i>, Causing Septicemia with Cholestatic Hepatitis in a Patient with Anti-Interferon-γ (IFN-γ) Autoantibodies |
title_short | <i>Francisella</i> sp., a Close Relative of <i>Francisella orientalis</i>, Causing Septicemia with Cholestatic Hepatitis in a Patient with Anti-Interferon-γ (IFN-γ) Autoantibodies |
title_sort | i francisella i sp a close relative of i francisella orientalis i causing septicemia with cholestatic hepatitis in a patient with anti interferon γ ifn γ autoantibodies |
topic | <i>Francisella philomiragia</i> genome anti-interferon-γ autoantibodies |
url | https://www.mdpi.com/2414-6366/7/2/25 |
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