Recent Progress in Nanoscale Covalent Organic Frameworks for Cancer Diagnosis and Therapy
Abstract Covalent organic frameworks (COFs) as a type of porous and crystalline covalent organic polymer are built up from covalently linked and periodically arranged organic molecules. Their precise assembly, well-defined coordination network, and tunable porosity endow COFs with diverse characteri...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2021-08-01
|
| Series: | Nano-Micro Letters |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s40820-021-00696-2 |
| _version_ | 1819137977493749760 |
|---|---|
| author | Shuncheng Yao Zhirong Liu Linlin Li |
| author_facet | Shuncheng Yao Zhirong Liu Linlin Li |
| author_sort | Shuncheng Yao |
| collection | DOAJ |
| description | Abstract Covalent organic frameworks (COFs) as a type of porous and crystalline covalent organic polymer are built up from covalently linked and periodically arranged organic molecules. Their precise assembly, well-defined coordination network, and tunable porosity endow COFs with diverse characteristics such as low density, high crystallinity, porous structure, and large specific-surface area, as well as versatile functions and active sites that can be tuned at molecular and atomic level. These unique properties make them excellent candidate materials for biomedical applications, such as drug delivery, diagnostic imaging, and disease therapy. To realize these functions, the components, dimensions, and guest molecule loading into COFs have a great influence on their performance in various applications. In this review, we first introduce the influence of dimensions, building blocks, and synthetic conditions on the chemical stability, pore structure, and chemical interaction with guest molecules of COFs. Next, the applications of COFs in cancer diagnosis and therapy are summarized. Finally, some challenges for COFs in cancer therapy are noted and the problems to be solved in the future are proposed. |
| first_indexed | 2024-12-22T10:59:27Z |
| format | Article |
| id | doaj.art-51d3f0ca30244cabacd1dc02ae9596b9 |
| institution | Directory Open Access Journal |
| issn | 2311-6706 2150-5551 |
| language | English |
| last_indexed | 2024-12-22T10:59:27Z |
| publishDate | 2021-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nano-Micro Letters |
| spelling | doaj.art-51d3f0ca30244cabacd1dc02ae9596b92022-12-21T18:28:34ZengSpringerOpenNano-Micro Letters2311-67062150-55512021-08-0113112010.1007/s40820-021-00696-2Recent Progress in Nanoscale Covalent Organic Frameworks for Cancer Diagnosis and TherapyShuncheng Yao0Zhirong Liu1Linlin Li2Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of SciencesBeijing Institute of Nanoenergy and Nanosystems, Chinese Academy of SciencesBeijing Institute of Nanoenergy and Nanosystems, Chinese Academy of SciencesAbstract Covalent organic frameworks (COFs) as a type of porous and crystalline covalent organic polymer are built up from covalently linked and periodically arranged organic molecules. Their precise assembly, well-defined coordination network, and tunable porosity endow COFs with diverse characteristics such as low density, high crystallinity, porous structure, and large specific-surface area, as well as versatile functions and active sites that can be tuned at molecular and atomic level. These unique properties make them excellent candidate materials for biomedical applications, such as drug delivery, diagnostic imaging, and disease therapy. To realize these functions, the components, dimensions, and guest molecule loading into COFs have a great influence on their performance in various applications. In this review, we first introduce the influence of dimensions, building blocks, and synthetic conditions on the chemical stability, pore structure, and chemical interaction with guest molecules of COFs. Next, the applications of COFs in cancer diagnosis and therapy are summarized. Finally, some challenges for COFs in cancer therapy are noted and the problems to be solved in the future are proposed.https://doi.org/10.1007/s40820-021-00696-2Covalent organic frameworksNanomedicineDrug deliveryCancer diagnosis and therapy |
| spellingShingle | Shuncheng Yao Zhirong Liu Linlin Li Recent Progress in Nanoscale Covalent Organic Frameworks for Cancer Diagnosis and Therapy Nano-Micro Letters Covalent organic frameworks Nanomedicine Drug delivery Cancer diagnosis and therapy |
| title | Recent Progress in Nanoscale Covalent Organic Frameworks for Cancer Diagnosis and Therapy |
| title_full | Recent Progress in Nanoscale Covalent Organic Frameworks for Cancer Diagnosis and Therapy |
| title_fullStr | Recent Progress in Nanoscale Covalent Organic Frameworks for Cancer Diagnosis and Therapy |
| title_full_unstemmed | Recent Progress in Nanoscale Covalent Organic Frameworks for Cancer Diagnosis and Therapy |
| title_short | Recent Progress in Nanoscale Covalent Organic Frameworks for Cancer Diagnosis and Therapy |
| title_sort | recent progress in nanoscale covalent organic frameworks for cancer diagnosis and therapy |
| topic | Covalent organic frameworks Nanomedicine Drug delivery Cancer diagnosis and therapy |
| url | https://doi.org/10.1007/s40820-021-00696-2 |
| work_keys_str_mv | AT shunchengyao recentprogressinnanoscalecovalentorganicframeworksforcancerdiagnosisandtherapy AT zhirongliu recentprogressinnanoscalecovalentorganicframeworksforcancerdiagnosisandtherapy AT linlinli recentprogressinnanoscalecovalentorganicframeworksforcancerdiagnosisandtherapy |