Aging Increases Hippocampal DUSP2 by a Membrane Cholesterol Loss-Mediated RTK/p38MAPK Activation Mechanism

Aging Increases Hippocampal DUSP2 by a Membrane Cholesterol Loss-Mediated RTK/p38MAPK Activation Mechanism

Numerous studies suggest that the increased activity of p38MAPK plays an important role in the abnormal immune and inflammatory response observed in the course of neurodegenerative diseases such as Alzheimer's disease. On the other hand, high levels of p38MAPK are present in the brain during no...

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Bibliographic Details
Main Authors: Adrián Martín-Segura, Álvaro Casadomé-Perales, Pietro Fazzari, José Manuel Mas, Laura Artigas, Raquel Valls, Angel R. Nebreda, Carlos G. Dotti
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Neurology
Subjects:
cholesterol
RTKs
p38MAPK
aging
DUSP2
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.00675/full

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