Longitudinal Dynamics of SARS-CoV-2 IgG Antibody Responses after the Two-Dose Regimen of BNT162b2 Vaccination and the Effect of a Third Dose on Healthcare Workers in Japan
Analysis of longitudinal dynamics of humoral immune responses to the BNT162b2 COVID-19 vaccine might provide useful information to predict the effectiveness of BNT162b2 in preventing SARS-CoV-2 infection. Herein, we measure anti-RBD IgG at 1, 3 and 6 months (M) after the second dose of BNT162b2, and...
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MDPI AG
2022-05-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/6/830 |
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| author | Atsuhiko Sakamoto Michinobu Yoshimura Ryota Itoh Ryo Ozuru Kazunari Ishii Yusuke Sechi Shigeki Nabeshima Kenji Hiromatsu |
| author_facet | Atsuhiko Sakamoto Michinobu Yoshimura Ryota Itoh Ryo Ozuru Kazunari Ishii Yusuke Sechi Shigeki Nabeshima Kenji Hiromatsu |
| author_sort | Atsuhiko Sakamoto |
| collection | DOAJ |
| description | Analysis of longitudinal dynamics of humoral immune responses to the BNT162b2 COVID-19 vaccine might provide useful information to predict the effectiveness of BNT162b2 in preventing SARS-CoV-2 infection. Herein, we measure anti-RBD IgG at 1, 3 and 6 months (M) after the second dose of BNT162b2, and at 1 M after a third dose of BNT162b2 vaccination in 431 COVID-19-naïve healthcare workers (HCWs) in Japan. All HCWs mounted high-anti-RBD IgG responses after the two-dose regimen of BNT162b2 vaccinations. Older persons and males presented lower anti-RBD IgG responses than younger adults and females, respectively. The decay in anti-RBD IgG started from 1 M after the second dose of BNT162b2 and anti-RBD IgG titers dropped to nearly one-tenth at 6 M after the second vaccination. Subsequently, the participants received a third dose of BNT162b2 at 8 M after the second dose of BNT162b2 vaccine. Anti-RBD antibody titers 1 M after the third dose of BNT162b2 increased seventeen times that of 6 M after the second dose, and was twice higher than the peak antibody titers at 1 M after the second dose of vaccination. The negative effect of age for the male gender on anti-RBD IgG antibody titers was not observed at 1 M after the third dose of BNT162b2 vaccine. There were no notable adverse events reported, which required hospitalization in these participants. These results suggest that the third dose of BNT162b2 safely improves humoral immunity against SARS-CoV-2 with no major adverse events. |
| first_indexed | 2024-03-09T22:18:08Z |
| format | Article |
| id | doaj.art-51d5791b9eb34573a920cbaaca6cddea |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T22:18:08Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-51d5791b9eb34573a920cbaaca6cddea2023-11-23T19:19:56ZengMDPI AGVaccines2076-393X2022-05-0110683010.3390/vaccines10060830Longitudinal Dynamics of SARS-CoV-2 IgG Antibody Responses after the Two-Dose Regimen of BNT162b2 Vaccination and the Effect of a Third Dose on Healthcare Workers in JapanAtsuhiko Sakamoto0Michinobu Yoshimura1Ryota Itoh2Ryo Ozuru3Kazunari Ishii4Yusuke Sechi5Shigeki Nabeshima6Kenji Hiromatsu7Department of Microbiology & Immunology, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, JapanDepartment of Microbiology & Immunology, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, JapanDepartment of Microbiology & Immunology, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, JapanDepartment of Microbiology & Immunology, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, JapanDepartment of Microbiology & Immunology, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, JapanGeneral Medicine, Fukuoka University Hospital, Fukuoka 814-0180, JapanGeneral Medicine, Fukuoka University Hospital, Fukuoka 814-0180, JapanDepartment of Microbiology & Immunology, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, JapanAnalysis of longitudinal dynamics of humoral immune responses to the BNT162b2 COVID-19 vaccine might provide useful information to predict the effectiveness of BNT162b2 in preventing SARS-CoV-2 infection. Herein, we measure anti-RBD IgG at 1, 3 and 6 months (M) after the second dose of BNT162b2, and at 1 M after a third dose of BNT162b2 vaccination in 431 COVID-19-naïve healthcare workers (HCWs) in Japan. All HCWs mounted high-anti-RBD IgG responses after the two-dose regimen of BNT162b2 vaccinations. Older persons and males presented lower anti-RBD IgG responses than younger adults and females, respectively. The decay in anti-RBD IgG started from 1 M after the second dose of BNT162b2 and anti-RBD IgG titers dropped to nearly one-tenth at 6 M after the second vaccination. Subsequently, the participants received a third dose of BNT162b2 at 8 M after the second dose of BNT162b2 vaccine. Anti-RBD antibody titers 1 M after the third dose of BNT162b2 increased seventeen times that of 6 M after the second dose, and was twice higher than the peak antibody titers at 1 M after the second dose of vaccination. The negative effect of age for the male gender on anti-RBD IgG antibody titers was not observed at 1 M after the third dose of BNT162b2 vaccine. There were no notable adverse events reported, which required hospitalization in these participants. These results suggest that the third dose of BNT162b2 safely improves humoral immunity against SARS-CoV-2 with no major adverse events.https://www.mdpi.com/2076-393X/10/6/830mRNA vaccineantibody responseSARS-CoV-2BNT162b2 |
| spellingShingle | Atsuhiko Sakamoto Michinobu Yoshimura Ryota Itoh Ryo Ozuru Kazunari Ishii Yusuke Sechi Shigeki Nabeshima Kenji Hiromatsu Longitudinal Dynamics of SARS-CoV-2 IgG Antibody Responses after the Two-Dose Regimen of BNT162b2 Vaccination and the Effect of a Third Dose on Healthcare Workers in Japan Vaccines mRNA vaccine antibody response SARS-CoV-2 BNT162b2 |
| title | Longitudinal Dynamics of SARS-CoV-2 IgG Antibody Responses after the Two-Dose Regimen of BNT162b2 Vaccination and the Effect of a Third Dose on Healthcare Workers in Japan |
| title_full | Longitudinal Dynamics of SARS-CoV-2 IgG Antibody Responses after the Two-Dose Regimen of BNT162b2 Vaccination and the Effect of a Third Dose on Healthcare Workers in Japan |
| title_fullStr | Longitudinal Dynamics of SARS-CoV-2 IgG Antibody Responses after the Two-Dose Regimen of BNT162b2 Vaccination and the Effect of a Third Dose on Healthcare Workers in Japan |
| title_full_unstemmed | Longitudinal Dynamics of SARS-CoV-2 IgG Antibody Responses after the Two-Dose Regimen of BNT162b2 Vaccination and the Effect of a Third Dose on Healthcare Workers in Japan |
| title_short | Longitudinal Dynamics of SARS-CoV-2 IgG Antibody Responses after the Two-Dose Regimen of BNT162b2 Vaccination and the Effect of a Third Dose on Healthcare Workers in Japan |
| title_sort | longitudinal dynamics of sars cov 2 igg antibody responses after the two dose regimen of bnt162b2 vaccination and the effect of a third dose on healthcare workers in japan |
| topic | mRNA vaccine antibody response SARS-CoV-2 BNT162b2 |
| url | https://www.mdpi.com/2076-393X/10/6/830 |
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