Retinal Capillary Rarefaction in Patients with Type 2 Diabetes Mellitus.
In diabetes mellitus type 2, capillary rarefaction plays a pivotal role in the pathogenesis of end-organ damage. We investigated retinal capillary density in patients with early disease.This cross-sectional study compares retinal capillary rarefaction determined by intercapillary distance (ICD) and...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5147800?pdf=render |
| _version_ | 1819113697233076224 |
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| author | Agnes Jumar Joanna M Harazny Christian Ott Stefanie Friedrich Iris Kistner Kristina Striepe Roland E Schmieder |
| author_facet | Agnes Jumar Joanna M Harazny Christian Ott Stefanie Friedrich Iris Kistner Kristina Striepe Roland E Schmieder |
| author_sort | Agnes Jumar |
| collection | DOAJ |
| description | In diabetes mellitus type 2, capillary rarefaction plays a pivotal role in the pathogenesis of end-organ damage. We investigated retinal capillary density in patients with early disease.This cross-sectional study compares retinal capillary rarefaction determined by intercapillary distance (ICD) and capillary area (CapA), measured non-invasively and in vivo by scanning laser Doppler flowmetry, in 73 patients with type 2 diabetes, 55 healthy controls and 134 individuals with hypertension stage 1 or 2.In diabetic patients, ICD was greater (23.2±5.5 vs 20.2±4.2, p = 0.013) and CapA smaller (1592±595 vs 1821±652, p = 0.019) than in healthy controls after adjustment for differences in cardiovascular risk factors between the groups. Compared to hypertensive patients, diabetic individuals showed no difference in ICD (23.1±5.8, p = 0.781) and CapA (1556±649, p = 0.768).In the early stage of diabetes type 2, patients showed capillary rarefaction compared to healthy individuals. |
| first_indexed | 2024-12-22T04:33:31Z |
| format | Article |
| id | doaj.art-51d9217ed1d8438aadc429bbf46cd5dc |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T04:33:31Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-51d9217ed1d8438aadc429bbf46cd5dc2022-12-21T18:38:58ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011112e016260810.1371/journal.pone.0162608Retinal Capillary Rarefaction in Patients with Type 2 Diabetes Mellitus.Agnes JumarJoanna M HaraznyChristian OttStefanie FriedrichIris KistnerKristina StriepeRoland E SchmiederIn diabetes mellitus type 2, capillary rarefaction plays a pivotal role in the pathogenesis of end-organ damage. We investigated retinal capillary density in patients with early disease.This cross-sectional study compares retinal capillary rarefaction determined by intercapillary distance (ICD) and capillary area (CapA), measured non-invasively and in vivo by scanning laser Doppler flowmetry, in 73 patients with type 2 diabetes, 55 healthy controls and 134 individuals with hypertension stage 1 or 2.In diabetic patients, ICD was greater (23.2±5.5 vs 20.2±4.2, p = 0.013) and CapA smaller (1592±595 vs 1821±652, p = 0.019) than in healthy controls after adjustment for differences in cardiovascular risk factors between the groups. Compared to hypertensive patients, diabetic individuals showed no difference in ICD (23.1±5.8, p = 0.781) and CapA (1556±649, p = 0.768).In the early stage of diabetes type 2, patients showed capillary rarefaction compared to healthy individuals.http://europepmc.org/articles/PMC5147800?pdf=render |
| spellingShingle | Agnes Jumar Joanna M Harazny Christian Ott Stefanie Friedrich Iris Kistner Kristina Striepe Roland E Schmieder Retinal Capillary Rarefaction in Patients with Type 2 Diabetes Mellitus. PLoS ONE |
| title | Retinal Capillary Rarefaction in Patients with Type 2 Diabetes Mellitus. |
| title_full | Retinal Capillary Rarefaction in Patients with Type 2 Diabetes Mellitus. |
| title_fullStr | Retinal Capillary Rarefaction in Patients with Type 2 Diabetes Mellitus. |
| title_full_unstemmed | Retinal Capillary Rarefaction in Patients with Type 2 Diabetes Mellitus. |
| title_short | Retinal Capillary Rarefaction in Patients with Type 2 Diabetes Mellitus. |
| title_sort | retinal capillary rarefaction in patients with type 2 diabetes mellitus |
| url | http://europepmc.org/articles/PMC5147800?pdf=render |
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