Physiological, hematological and biochemical factors associated with high-altitude headache in young Chinese males following acute exposure at 3700 m
Abstract Background High-altitude headache (HAH) is the most common sickness occurred in healthy people after rapid ascending to high altitude, and its risk factors were still not well understood. To investigate physiological, hematological and biochemical risk factors associated with high-altitude...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-07-01
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| Series: | The Journal of Headache and Pain |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s10194-018-0878-7 |
| _version_ | 1818297175805788160 |
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| author | Kun Wang Menghan Zhang Yi Li Weilin Pu Yanyun Ma Yi Wang Xiaoyu Liu Longli Kang Xiaofeng Wang Jiucun Wang Bin Qiao Li Jin |
| author_facet | Kun Wang Menghan Zhang Yi Li Weilin Pu Yanyun Ma Yi Wang Xiaoyu Liu Longli Kang Xiaofeng Wang Jiucun Wang Bin Qiao Li Jin |
| author_sort | Kun Wang |
| collection | DOAJ |
| description | Abstract Background High-altitude headache (HAH) is the most common sickness occurred in healthy people after rapid ascending to high altitude, and its risk factors were still not well understood. To investigate physiological, hematological and biochemical risk factors associated with high-altitude headache (HAH) after acute exposure to 3700 m, we conducted a two-stage, perspective observational study. In 72 h, total 318 young Han Chinese males ascended from sea level (altitude of 50 m) to altitude of 3700 m by train. Demographic data, physiological, hematological and biochemical parameters of all participants were collected within one week prior to the departure, and within 24 h after arrival. Results The incidence of HAH was 74.84%. For parameters measured at sea level, participants with HAH exhibited significantly higher age and lower BUN (p < 0.05). For parameters measured at 3700 m, participants with HAH exhibited significantly lower blood oxygen saturation (SpO2), higher resting heart rate (HR), higher systolic blood pressure at resting (SBP) and lower blood urea nitrogen (BUN) (all p < 0.05). At 3700 m, the severity of HAH associated with SpO2, HR and BUN significantly (all p < 0.05). Multivariate logistic regression revealed that for parameters at sea level, BUN was associated with HAH [BUN (OR:0.77, 95% CI:0.60–0.99)] and for parameters at 3700 m, SpO2, HR and BUN were associated with HAH independently [SpO2 (OR:0.84, 95% CI:0.76–0.93); HR (OR:1.03, 95% CI:1.00–1.07); BUN (OR:0.64, 95% CI:0.46–0.88)]. No association between hematological parameters and HAH was observed. Conclusion We confirmed that higher HR, lower SpO2 are independent risk factors for HAH. Furthermore, we found that at both 50 m and 3700 m, lower BUN is a novel independent risk factor for HAH, providing new insights for understanding the pathological mechanisms. |
| first_indexed | 2024-12-13T04:15:16Z |
| format | Article |
| id | doaj.art-51d953b4d57241e9a826c514f24a6bee |
| institution | Directory Open Access Journal |
| issn | 1129-2369 1129-2377 |
| language | English |
| last_indexed | 2024-12-13T04:15:16Z |
| publishDate | 2018-07-01 |
| publisher | BMC |
| record_format | Article |
| series | The Journal of Headache and Pain |
| spelling | doaj.art-51d953b4d57241e9a826c514f24a6bee2022-12-21T23:59:55ZengBMCThe Journal of Headache and Pain1129-23691129-23772018-07-0119111110.1186/s10194-018-0878-7Physiological, hematological and biochemical factors associated with high-altitude headache in young Chinese males following acute exposure at 3700 mKun Wang0Menghan Zhang1Yi Li2Weilin Pu3Yanyun Ma4Yi Wang5Xiaoyu Liu6Longli Kang7Xiaofeng Wang8Jiucun Wang9Bin Qiao10Li Jin11State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan UniversityMinistry of Education Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan UniversityMinistry of Education Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan UniversityMinistry of Education Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan UniversityMinistry of Education Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan UniversityMinistry of Education Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan UniversityMinistry of Education Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan UniversityKey Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu UniversityState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan UniversityState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan UniversityInstitute of Cardiovascular Disease, General Hospital of Jinan Military RegionState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan UniversityAbstract Background High-altitude headache (HAH) is the most common sickness occurred in healthy people after rapid ascending to high altitude, and its risk factors were still not well understood. To investigate physiological, hematological and biochemical risk factors associated with high-altitude headache (HAH) after acute exposure to 3700 m, we conducted a two-stage, perspective observational study. In 72 h, total 318 young Han Chinese males ascended from sea level (altitude of 50 m) to altitude of 3700 m by train. Demographic data, physiological, hematological and biochemical parameters of all participants were collected within one week prior to the departure, and within 24 h after arrival. Results The incidence of HAH was 74.84%. For parameters measured at sea level, participants with HAH exhibited significantly higher age and lower BUN (p < 0.05). For parameters measured at 3700 m, participants with HAH exhibited significantly lower blood oxygen saturation (SpO2), higher resting heart rate (HR), higher systolic blood pressure at resting (SBP) and lower blood urea nitrogen (BUN) (all p < 0.05). At 3700 m, the severity of HAH associated with SpO2, HR and BUN significantly (all p < 0.05). Multivariate logistic regression revealed that for parameters at sea level, BUN was associated with HAH [BUN (OR:0.77, 95% CI:0.60–0.99)] and for parameters at 3700 m, SpO2, HR and BUN were associated with HAH independently [SpO2 (OR:0.84, 95% CI:0.76–0.93); HR (OR:1.03, 95% CI:1.00–1.07); BUN (OR:0.64, 95% CI:0.46–0.88)]. No association between hematological parameters and HAH was observed. Conclusion We confirmed that higher HR, lower SpO2 are independent risk factors for HAH. Furthermore, we found that at both 50 m and 3700 m, lower BUN is a novel independent risk factor for HAH, providing new insights for understanding the pathological mechanisms.http://link.springer.com/article/10.1186/s10194-018-0878-7High-altitude headacheHypoxiaBlood urea nitrogenOxygen saturationHeart rate |
| spellingShingle | Kun Wang Menghan Zhang Yi Li Weilin Pu Yanyun Ma Yi Wang Xiaoyu Liu Longli Kang Xiaofeng Wang Jiucun Wang Bin Qiao Li Jin Physiological, hematological and biochemical factors associated with high-altitude headache in young Chinese males following acute exposure at 3700 m The Journal of Headache and Pain High-altitude headache Hypoxia Blood urea nitrogen Oxygen saturation Heart rate |
| title | Physiological, hematological and biochemical factors associated with high-altitude headache in young Chinese males following acute exposure at 3700 m |
| title_full | Physiological, hematological and biochemical factors associated with high-altitude headache in young Chinese males following acute exposure at 3700 m |
| title_fullStr | Physiological, hematological and biochemical factors associated with high-altitude headache in young Chinese males following acute exposure at 3700 m |
| title_full_unstemmed | Physiological, hematological and biochemical factors associated with high-altitude headache in young Chinese males following acute exposure at 3700 m |
| title_short | Physiological, hematological and biochemical factors associated with high-altitude headache in young Chinese males following acute exposure at 3700 m |
| title_sort | physiological hematological and biochemical factors associated with high altitude headache in young chinese males following acute exposure at 3700 m |
| topic | High-altitude headache Hypoxia Blood urea nitrogen Oxygen saturation Heart rate |
| url | http://link.springer.com/article/10.1186/s10194-018-0878-7 |
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