Antiviral options and therapeutics against influenza: history, latest developments and future prospects
Drugs and chemotherapeutics have helped to manage devastating impacts of infectious diseases since the concept of ‘magic bullet’. The World Health Organization estimates about 650,000 deaths due to respiratory diseases linked to seasonal influenza each year. Pandemic influenza, on the other hand, is...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1269344/full |
| _version_ | 1797448588746293248 |
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| author | Clement Meseko Melvin Sanicas Kumari Asha Lanre Sulaiman Binod Kumar |
| author_facet | Clement Meseko Melvin Sanicas Kumari Asha Lanre Sulaiman Binod Kumar |
| author_sort | Clement Meseko |
| collection | DOAJ |
| description | Drugs and chemotherapeutics have helped to manage devastating impacts of infectious diseases since the concept of ‘magic bullet’. The World Health Organization estimates about 650,000 deaths due to respiratory diseases linked to seasonal influenza each year. Pandemic influenza, on the other hand, is the most feared health disaster and probably would have greater and immediate impact on humanity than climate change. While countermeasures, biosecurity and vaccination remain the most effective preventive strategies against this highly infectious and communicable disease, antivirals are nonetheless essential to mitigate clinical manifestations following infection and to reduce devastating complications and mortality. Continuous emergence of the novel strains of rapidly evolving influenza viruses, some of which are intractable, require new approaches towards influenza chemotherapeutics including optimization of existing anti-infectives and search for novel therapies. Effective management of influenza infections depend on the safety and efficacy of selected anti-infective in-vitro studies and their clinical applications. The outcomes of therapies are also dependent on understanding diversity in patient groups, co-morbidities, co-infections and combination therapies. In this extensive review, we have discussed the challenges of influenza epidemics and pandemics and discoursed the options for anti-viral chemotherapies for effective management of influenza virus infections. |
| first_indexed | 2024-03-09T14:12:42Z |
| format | Article |
| id | doaj.art-51da3cbe525f47a894336418c5f39fbc |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-09T14:12:42Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-51da3cbe525f47a894336418c5f39fbc2023-11-29T05:54:10ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-11-011310.3389/fcimb.2023.12693441269344Antiviral options and therapeutics against influenza: history, latest developments and future prospectsClement Meseko0Melvin Sanicas1Kumari Asha2Lanre Sulaiman3Binod Kumar4Regional Centre for Animal Influenza, National Veterinary Research Institute, Vom, NigeriaMedical and Clinical Development, Clover Biopharmaceuticals, Boston, MA, United StatesDepartment of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, United StatesRegional Centre for Animal Influenza, National Veterinary Research Institute, Vom, NigeriaDepartment of Antiviral Research, Institute of Advanced Virology, Thiruvananthapuram, Kerala, IndiaDrugs and chemotherapeutics have helped to manage devastating impacts of infectious diseases since the concept of ‘magic bullet’. The World Health Organization estimates about 650,000 deaths due to respiratory diseases linked to seasonal influenza each year. Pandemic influenza, on the other hand, is the most feared health disaster and probably would have greater and immediate impact on humanity than climate change. While countermeasures, biosecurity and vaccination remain the most effective preventive strategies against this highly infectious and communicable disease, antivirals are nonetheless essential to mitigate clinical manifestations following infection and to reduce devastating complications and mortality. Continuous emergence of the novel strains of rapidly evolving influenza viruses, some of which are intractable, require new approaches towards influenza chemotherapeutics including optimization of existing anti-infectives and search for novel therapies. Effective management of influenza infections depend on the safety and efficacy of selected anti-infective in-vitro studies and their clinical applications. The outcomes of therapies are also dependent on understanding diversity in patient groups, co-morbidities, co-infections and combination therapies. In this extensive review, we have discussed the challenges of influenza epidemics and pandemics and discoursed the options for anti-viral chemotherapies for effective management of influenza virus infections.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1269344/fullinfluenza virusinfluenza therapeuticsantiviral drugsepidemicspandemicsanti-infectives |
| spellingShingle | Clement Meseko Melvin Sanicas Kumari Asha Lanre Sulaiman Binod Kumar Antiviral options and therapeutics against influenza: history, latest developments and future prospects Frontiers in Cellular and Infection Microbiology influenza virus influenza therapeutics antiviral drugs epidemics pandemics anti-infectives |
| title | Antiviral options and therapeutics against influenza: history, latest developments and future prospects |
| title_full | Antiviral options and therapeutics against influenza: history, latest developments and future prospects |
| title_fullStr | Antiviral options and therapeutics against influenza: history, latest developments and future prospects |
| title_full_unstemmed | Antiviral options and therapeutics against influenza: history, latest developments and future prospects |
| title_short | Antiviral options and therapeutics against influenza: history, latest developments and future prospects |
| title_sort | antiviral options and therapeutics against influenza history latest developments and future prospects |
| topic | influenza virus influenza therapeutics antiviral drugs epidemics pandemics anti-infectives |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1269344/full |
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