Oxidized low-density lipoprotein and ankle-brachial pressure index in patients with clinically evident peripheral arterial disease
OBJECTIVES: To investigate whether oxidized low-density lipoprotein is a suitable predictor of peripheral arterial disease severity. The role of oxidized low-density lipoprotein in the pathogenesis of atherosclerosis has already been investigated. Its relevance as a predictor of the appearance and w...
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| Format: | Article |
| Language: | English |
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Elsevier España
2010-01-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322010000400006 |
| _version_ | 1818237312368115712 |
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| author | Ruben Miguel Ayzin Rosoky Nelson Wolosker Michel Nasser Antonio Eduardo Zerati Magnus Gidlund Pedro Puech-Leão |
| author_facet | Ruben Miguel Ayzin Rosoky Nelson Wolosker Michel Nasser Antonio Eduardo Zerati Magnus Gidlund Pedro Puech-Leão |
| author_sort | Ruben Miguel Ayzin Rosoky |
| collection | DOAJ |
| description | OBJECTIVES: To investigate whether oxidized low-density lipoprotein is a suitable predictor of peripheral arterial disease severity. The role of oxidized low-density lipoprotein in the pathogenesis of atherosclerosis has already been investigated. Its relevance as a predictor of the appearance and worsening of coronary arterial disease is also well known. However, the same is not true regarding peripheral arterial disease. METHOD: Eighty-five consecutive patients with an ankle-brachial pressure index (ABPI) < 0.9 and the presence of either intermittent claudication or critical lower leg ischemia were included. The plasma level of IgG autoantibodies against oxidized low-density lipoprotein was evaluated through an enzyme-linked immunosorbent assay. The results were categorized into quartiles according to the ankle-brachial pressure index (a marker of peripheral arterial disease severity), and significant differences were investigated with the Kruskal-Wallis test. RESULTS: There was no significant difference between the quartiles for this population (p = 0.33). No correlation was found between the ankle-brachial pressure index and oxidized low-density lipoprotein levels in subjects with clinically evident peripheral arterial disease with a wide range of clinical manifestations. CONCLUSIONS: Oxidized low-density lipoprotein is not a good predictor of peripheral arterial disease severity. |
| first_indexed | 2024-12-12T12:23:45Z |
| format | Article |
| id | doaj.art-51db47182532420aa95bf6716ffb32ae |
| institution | Directory Open Access Journal |
| issn | 1807-5932 1980-5322 |
| language | English |
| last_indexed | 2024-12-12T12:23:45Z |
| publishDate | 2010-01-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-51db47182532420aa95bf6716ffb32ae2022-12-22T00:24:36ZengElsevier EspañaClinics1807-59321980-53222010-01-0165438338710.1590/S1807-59322010000400006Oxidized low-density lipoprotein and ankle-brachial pressure index in patients with clinically evident peripheral arterial diseaseRuben Miguel Ayzin RosokyNelson WoloskerMichel NasserAntonio Eduardo ZeratiMagnus GidlundPedro Puech-LeãoOBJECTIVES: To investigate whether oxidized low-density lipoprotein is a suitable predictor of peripheral arterial disease severity. The role of oxidized low-density lipoprotein in the pathogenesis of atherosclerosis has already been investigated. Its relevance as a predictor of the appearance and worsening of coronary arterial disease is also well known. However, the same is not true regarding peripheral arterial disease. METHOD: Eighty-five consecutive patients with an ankle-brachial pressure index (ABPI) < 0.9 and the presence of either intermittent claudication or critical lower leg ischemia were included. The plasma level of IgG autoantibodies against oxidized low-density lipoprotein was evaluated through an enzyme-linked immunosorbent assay. The results were categorized into quartiles according to the ankle-brachial pressure index (a marker of peripheral arterial disease severity), and significant differences were investigated with the Kruskal-Wallis test. RESULTS: There was no significant difference between the quartiles for this population (p = 0.33). No correlation was found between the ankle-brachial pressure index and oxidized low-density lipoprotein levels in subjects with clinically evident peripheral arterial disease with a wide range of clinical manifestations. CONCLUSIONS: Oxidized low-density lipoprotein is not a good predictor of peripheral arterial disease severity.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322010000400006AtherosclerosisCholesterolFree radicalLimb ischemiaPredictor |
| spellingShingle | Ruben Miguel Ayzin Rosoky Nelson Wolosker Michel Nasser Antonio Eduardo Zerati Magnus Gidlund Pedro Puech-Leão Oxidized low-density lipoprotein and ankle-brachial pressure index in patients with clinically evident peripheral arterial disease Clinics Atherosclerosis Cholesterol Free radical Limb ischemia Predictor |
| title | Oxidized low-density lipoprotein and ankle-brachial pressure index in patients with clinically evident peripheral arterial disease |
| title_full | Oxidized low-density lipoprotein and ankle-brachial pressure index in patients with clinically evident peripheral arterial disease |
| title_fullStr | Oxidized low-density lipoprotein and ankle-brachial pressure index in patients with clinically evident peripheral arterial disease |
| title_full_unstemmed | Oxidized low-density lipoprotein and ankle-brachial pressure index in patients with clinically evident peripheral arterial disease |
| title_short | Oxidized low-density lipoprotein and ankle-brachial pressure index in patients with clinically evident peripheral arterial disease |
| title_sort | oxidized low density lipoprotein and ankle brachial pressure index in patients with clinically evident peripheral arterial disease |
| topic | Atherosclerosis Cholesterol Free radical Limb ischemia Predictor |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322010000400006 |
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