A spike-modified Middle East respiratory syndrome coronavirus (MERS-CoV) infectious clone elicits mild respiratory disease in infected rhesus macaques

A spike-modified Middle East respiratory syndrome coronavirus (MERS-CoV) infectious clone elicits mild respiratory disease in infected rhesus macaques

Abstract The recurrence of new human cases of Middle East respiratory syndrome coronavirus (MERS-CoV) underscores the need for effective therapeutic countermeasures. Nonhuman primate models are considered the gold standard for preclinical evaluation of therapeutic countermeasures. However, MERS-CoV-...

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Bibliographic Details
Main Authors: Adam S. Cockrell, Joshua C. Johnson, Ian N. Moore, David X. Liu, Kevin W. Bock, Madeline G. Douglas, Rachel L. Graham, Jeffrey Solomon, Lisa Torzewski, Christopher Bartos, Randy Hart, Ralph S. Baric, Reed F. Johnson
Format: Article
Language:English
Published: Nature Portfolio 2018-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-28900-1

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