Phenotypic features of genetically modified DMD-XKOXWT pigs

Phenotypic features of genetically modified DMD-XKOXWT pigs

Introduction: Duchenne muscular dystrophy (DMD) is a hereditary neuromuscular disorder caused by mutation in the dystrophin gene (DMD) on the X chromosome. Female DMD carriers occasionally exhibit symptoms such as muscle weakness and heart failure. Here, we investigated the characteristics and repre...

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Main Authors: Kazutoshi Okamoto, Hitomi Matsunari, Kazuaki Nakano, Kazuhiro Umeyama, Koki Hasegawa, Ayuko Uchikura, Shuko Takayanagi, Masahito Watanabe, Jun Ohgane, Michael Stirm, Mayuko Kurome, Nikolai Klymiuk, Masaki Nagaya, Eckhard Wolf, Hiroshi Nagashima
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Regenerative Therapy
Subjects:
Dystrophinopathy
Carrier
Duchenne muscular dystrophy
Hereditary disease
Large animal model
Pig
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320423000925

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