The effect of varicella-zoster virus reactivation on the long-term outcomes of patients undergoing allogeneic hematopoietic stem cell transplantation
Abstract Background A virus infection may lead the body to produce more immune cells of particular types or stimulate the production of new ones, both of which may have anti-leukemic effects. There has been no research on whether immune cells stimulated by varicella-zoster virus (VZV) infection have...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | Journal of Health, Population and Nutrition |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41043-023-00429-8 |
| _version_ | 1827633819089371136 |
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| author | Ping Li Jingxia Li Haoyuan Huang Xiongnong Chen Yue Lin Ganlin He Duorong Xu |
| author_facet | Ping Li Jingxia Li Haoyuan Huang Xiongnong Chen Yue Lin Ganlin He Duorong Xu |
| author_sort | Ping Li |
| collection | DOAJ |
| description | Abstract Background A virus infection may lead the body to produce more immune cells of particular types or stimulate the production of new ones, both of which may have anti-leukemic effects. There has been no research on whether immune cells stimulated by varicella-zoster virus (VZV) infection have anti-leukemic effects. The objective of this investigation is to assess the impact of VZV infection on patients' long-term survival following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods This retrospective study investigated the association between varicella-zoster virus (VZV) reactivation and outcomes in 219 individuals who received allogeneic hematopoietic stem cell transplantation (allo-HSCT) at the Sun Yat-sen University’s First Affiliated Hospital. According to being diagnosed with VZV infection or not, these patients were grouped into two groups. The comparison of cumulative incidence of relapse, non-recurrent mortality, and overall survival (OS) was conducted between the two groups. Results Analyzing multivariate data, VZV reactivation was linked to lower relapse incidence in the group containing all individuals (hazard ratio [HR] = 0.27; 95% confidence interval [CI], 0.12–0.64), patients suffering from acute myeloid leukaemia (HR = 0.10; 95% CI, 0.01–0.83), and patients suffering from acute lymphoblastic leukaemia (HR = 0.25; 95% CI, 0.08–0.77). Moreover, VZV reactivation was linked with decreased non-relapse mortality in all individuals (HR = 0.20; 95% CI, 0.05–0.79), but no statistical significance was found for any disease subgroup. Further, VZV reactivation was an independent predictor for improved OS in the group containing all individuals (HR = 0.10; 95% CI, 0.03–0.29), patients suffering from acute myeloid leukaemia (HR = 0.09; 95% CI, 0.01–0.66), and patients suffering from acute lymphoblastic leukaemia (HR = 0.16; 95% CI, 0.04–0.68). Conclusion This is the first study to show that VZV reactivation following allo-HSCT is an independent predictor for lower relapse rates and improved OS, providing novel therapeutic approaches to improve patients’ long-term survival following allo-HSCT. |
| first_indexed | 2024-03-09T15:04:49Z |
| format | Article |
| id | doaj.art-51df75d43d3644bcba993330bb4ae1e6 |
| institution | Directory Open Access Journal |
| issn | 2072-1315 |
| language | English |
| last_indexed | 2024-03-09T15:04:49Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Health, Population and Nutrition |
| spelling | doaj.art-51df75d43d3644bcba993330bb4ae1e62023-11-26T13:41:38ZengBMCJournal of Health, Population and Nutrition2072-13152023-10-0142111010.1186/s41043-023-00429-8The effect of varicella-zoster virus reactivation on the long-term outcomes of patients undergoing allogeneic hematopoietic stem cell transplantationPing Li0Jingxia Li1Haoyuan Huang2Xiongnong Chen3Yue Lin4Ganlin He5Duorong Xu6Department of Haematology, The First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Haematology, The First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Haematology, The First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Haematology, The First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Haematology, The First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Haematology, The First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Haematology, The First Affiliated Hospital of Sun Yat-sen UniversityAbstract Background A virus infection may lead the body to produce more immune cells of particular types or stimulate the production of new ones, both of which may have anti-leukemic effects. There has been no research on whether immune cells stimulated by varicella-zoster virus (VZV) infection have anti-leukemic effects. The objective of this investigation is to assess the impact of VZV infection on patients' long-term survival following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods This retrospective study investigated the association between varicella-zoster virus (VZV) reactivation and outcomes in 219 individuals who received allogeneic hematopoietic stem cell transplantation (allo-HSCT) at the Sun Yat-sen University’s First Affiliated Hospital. According to being diagnosed with VZV infection or not, these patients were grouped into two groups. The comparison of cumulative incidence of relapse, non-recurrent mortality, and overall survival (OS) was conducted between the two groups. Results Analyzing multivariate data, VZV reactivation was linked to lower relapse incidence in the group containing all individuals (hazard ratio [HR] = 0.27; 95% confidence interval [CI], 0.12–0.64), patients suffering from acute myeloid leukaemia (HR = 0.10; 95% CI, 0.01–0.83), and patients suffering from acute lymphoblastic leukaemia (HR = 0.25; 95% CI, 0.08–0.77). Moreover, VZV reactivation was linked with decreased non-relapse mortality in all individuals (HR = 0.20; 95% CI, 0.05–0.79), but no statistical significance was found for any disease subgroup. Further, VZV reactivation was an independent predictor for improved OS in the group containing all individuals (HR = 0.10; 95% CI, 0.03–0.29), patients suffering from acute myeloid leukaemia (HR = 0.09; 95% CI, 0.01–0.66), and patients suffering from acute lymphoblastic leukaemia (HR = 0.16; 95% CI, 0.04–0.68). Conclusion This is the first study to show that VZV reactivation following allo-HSCT is an independent predictor for lower relapse rates and improved OS, providing novel therapeutic approaches to improve patients’ long-term survival following allo-HSCT.https://doi.org/10.1186/s41043-023-00429-8Allogeneic hematopoietic stem cell transplantationVaricella-zoster virus reactivationRelapseOverall survival |
| spellingShingle | Ping Li Jingxia Li Haoyuan Huang Xiongnong Chen Yue Lin Ganlin He Duorong Xu The effect of varicella-zoster virus reactivation on the long-term outcomes of patients undergoing allogeneic hematopoietic stem cell transplantation Journal of Health, Population and Nutrition Allogeneic hematopoietic stem cell transplantation Varicella-zoster virus reactivation Relapse Overall survival |
| title | The effect of varicella-zoster virus reactivation on the long-term outcomes of patients undergoing allogeneic hematopoietic stem cell transplantation |
| title_full | The effect of varicella-zoster virus reactivation on the long-term outcomes of patients undergoing allogeneic hematopoietic stem cell transplantation |
| title_fullStr | The effect of varicella-zoster virus reactivation on the long-term outcomes of patients undergoing allogeneic hematopoietic stem cell transplantation |
| title_full_unstemmed | The effect of varicella-zoster virus reactivation on the long-term outcomes of patients undergoing allogeneic hematopoietic stem cell transplantation |
| title_short | The effect of varicella-zoster virus reactivation on the long-term outcomes of patients undergoing allogeneic hematopoietic stem cell transplantation |
| title_sort | effect of varicella zoster virus reactivation on the long term outcomes of patients undergoing allogeneic hematopoietic stem cell transplantation |
| topic | Allogeneic hematopoietic stem cell transplantation Varicella-zoster virus reactivation Relapse Overall survival |
| url | https://doi.org/10.1186/s41043-023-00429-8 |
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