Mendelian Randomization With Refined Instrumental Variables From Genetic Score Improves Accuracy and Reduces Bias

Mendelian Randomization With Refined Instrumental Variables From Genetic Score Improves Accuracy and Reduces Bias

Mendelian randomization (MR) can estimate the causal effect for a risk factor on a complex disease using genetic variants as instrument variables (IVs). A variety of generalized MR methods have been proposed to integrate results arising from multiple IVs in order to increase power. One of the method...

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Bibliographic Details
Main Authors: Lijuan Lin, Ruyang Zhang, Hui Huang, Ying Zhu, Yi Li, Xuesi Dong, Sipeng Shen, Liangmin Wei, Xin Chen, David C. Christiani, Yongyue Wei, Feng Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Genetics
Subjects:
Mendelian randomization
multiple correlated instrumental variables
genetic score
metabolomics
educational attainment
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.618829/full

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