Contributions of viral oncogenes of HPV-18 and hypoxia to oxidative stress and genetic damage in human keratinocytes

Contributions of viral oncogenes of HPV-18 and hypoxia to oxidative stress and genetic damage in human keratinocytes

Abstract Infection with high-risk human papillomaviruses like HPV-16 and HPV-18 is highly associated with the development of cervical and other cancers. Malignant transformation requires viral oncoproteins E5, E6 and E7, which promote cell proliferation and increase DNA damage. Oxidative stress and...

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Main Authors: Jimena Hochmann, Magdalena Millán, Paola Hernández, Laura Lafon-Hughes, Natali D’ Aiuto, Alejandro Silva, Juan Llaguno, Julia Alonso, Ariel Fernández, Vanesa Pereira-Prado, José Sotelo-Silveira, Ronell Bologna-Molina, Miguel Arocena
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-44880-3

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