Serum C‐reactive protein greater than 75 mg/dL as an early available laboratory predictor of severe COVID‐19: A systematic review
Abstract Introduction Severe COVID‐19 management is still challenging. Having a laboratory factor to predict the severity of a patient's condition can be very useful in how to approach each patient. There have been studies concentrating on the correlation between serum C‐reactive protein (CRP)...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-12-01
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| Series: | Immunity, Inflammation and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/iid3.1130 |
| _version_ | 1827395784371339264 |
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| author | Pershang Nazemi SeyedAhmad SeyedAlinaghi Ayein Azarnoush Avin Mabadi Arezoo Salami Khaneshan Mohammadreza Salehi |
| author_facet | Pershang Nazemi SeyedAhmad SeyedAlinaghi Ayein Azarnoush Avin Mabadi Arezoo Salami Khaneshan Mohammadreza Salehi |
| author_sort | Pershang Nazemi |
| collection | DOAJ |
| description | Abstract Introduction Severe COVID‐19 management is still challenging. Having a laboratory factor to predict the severity of a patient's condition can be very useful in how to approach each patient. There have been studies concentrating on the correlation between serum C‐reactive protein (CRP) level and COVID‐19 severity but we aim to reach a threshold for CRP in disease severity determination. Methods We conducted a thorough search on PubMed, Web of Science and Google Scholar databases from early 2019 to October 2021, and 323 studies were assessed for eligibility in three phases. We used the Newcastle‐Ottawa Scale to examine the validity of the studies. The t‐test was applied for the CRP level cutoffs. Results Eventually, 11 articles and 1615 patients were included in this systematic review. Our analysis evaluated combined mean, median, and standard deviation of severe patients' CRP to be respectively 73.37, 53.80, and 47.936. Based on the combined mean, 75 mg/dL was suggested as an initial threshold for baseline CRP in hospitalized patients for developing severe conditions. Conclusion This study recommends that COVID‐19 patients with on‐admission serum CRP levels of 75 mg/dL and more are likely associated with severe conditions. Thus, anti‐inflammatory agents and further following may be helpful in these patients. |
| first_indexed | 2024-03-08T18:39:48Z |
| format | Article |
| id | doaj.art-51e430e82ec04182a51bfc44569a340d |
| institution | Directory Open Access Journal |
| issn | 2050-4527 |
| language | English |
| last_indexed | 2024-03-08T18:39:48Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj.art-51e430e82ec04182a51bfc44569a340d2023-12-29T08:52:36ZengWileyImmunity, Inflammation and Disease2050-45272023-12-011112n/an/a10.1002/iid3.1130Serum C‐reactive protein greater than 75 mg/dL as an early available laboratory predictor of severe COVID‐19: A systematic reviewPershang Nazemi0SeyedAhmad SeyedAlinaghi1Ayein Azarnoush2Avin Mabadi3Arezoo Salami Khaneshan4Mohammadreza Salehi5Department of Infectious Diseases, Imam Khomeini and Yas Hospital Complex Tehran University of Medical Sciences Tehran IranIranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High‐Risk Behaviors Tehran University of Medical Sciences Tehran IranIranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High‐Risk Behaviors Tehran University of Medical Sciences Tehran IranMedical School Iran University of Medical Sciences Tehran IranDepartment of Infectious Diseases, Imam Khomeini Hospital Complex Tehran University of Medical Sciences Tehran IranDepartment of Infectious Diseases, Imam Khomeini Hospital Complex Tehran University of Medical Sciences Tehran IranAbstract Introduction Severe COVID‐19 management is still challenging. Having a laboratory factor to predict the severity of a patient's condition can be very useful in how to approach each patient. There have been studies concentrating on the correlation between serum C‐reactive protein (CRP) level and COVID‐19 severity but we aim to reach a threshold for CRP in disease severity determination. Methods We conducted a thorough search on PubMed, Web of Science and Google Scholar databases from early 2019 to October 2021, and 323 studies were assessed for eligibility in three phases. We used the Newcastle‐Ottawa Scale to examine the validity of the studies. The t‐test was applied for the CRP level cutoffs. Results Eventually, 11 articles and 1615 patients were included in this systematic review. Our analysis evaluated combined mean, median, and standard deviation of severe patients' CRP to be respectively 73.37, 53.80, and 47.936. Based on the combined mean, 75 mg/dL was suggested as an initial threshold for baseline CRP in hospitalized patients for developing severe conditions. Conclusion This study recommends that COVID‐19 patients with on‐admission serum CRP levels of 75 mg/dL and more are likely associated with severe conditions. Thus, anti‐inflammatory agents and further following may be helpful in these patients.https://doi.org/10.1002/iid3.1130COVID‐19C‐reactive proteininflammationprognosis |
| spellingShingle | Pershang Nazemi SeyedAhmad SeyedAlinaghi Ayein Azarnoush Avin Mabadi Arezoo Salami Khaneshan Mohammadreza Salehi Serum C‐reactive protein greater than 75 mg/dL as an early available laboratory predictor of severe COVID‐19: A systematic review Immunity, Inflammation and Disease COVID‐19 C‐reactive protein inflammation prognosis |
| title | Serum C‐reactive protein greater than 75 mg/dL as an early available laboratory predictor of severe COVID‐19: A systematic review |
| title_full | Serum C‐reactive protein greater than 75 mg/dL as an early available laboratory predictor of severe COVID‐19: A systematic review |
| title_fullStr | Serum C‐reactive protein greater than 75 mg/dL as an early available laboratory predictor of severe COVID‐19: A systematic review |
| title_full_unstemmed | Serum C‐reactive protein greater than 75 mg/dL as an early available laboratory predictor of severe COVID‐19: A systematic review |
| title_short | Serum C‐reactive protein greater than 75 mg/dL as an early available laboratory predictor of severe COVID‐19: A systematic review |
| title_sort | serum c reactive protein greater than 75 mg dl as an early available laboratory predictor of severe covid 19 a systematic review |
| topic | COVID‐19 C‐reactive protein inflammation prognosis |
| url | https://doi.org/10.1002/iid3.1130 |
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