Primitive Compartmentalization for the Sustainable Replication of Genetic Molecules

Sustainable replication and evolution of genetic molecules such as RNA are likely requisites for the emergence of life; however, these processes are easily affected by the appearance of parasitic molecules that replicate by relying on the function of other molecules, while not contributing to their...

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Main Authors: Ryo Mizuuchi, Norikazu Ichihashi
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Life
Subjects:
Online Access:https://www.mdpi.com/2075-1729/11/3/191
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author Ryo Mizuuchi
Norikazu Ichihashi
author_facet Ryo Mizuuchi
Norikazu Ichihashi
author_sort Ryo Mizuuchi
collection DOAJ
description Sustainable replication and evolution of genetic molecules such as RNA are likely requisites for the emergence of life; however, these processes are easily affected by the appearance of parasitic molecules that replicate by relying on the function of other molecules, while not contributing to their replication. A possible mechanism to repress parasite amplification is compartmentalization that segregates parasitic molecules and limits their access to functional genetic molecules. Although extent cells encapsulate genomes within lipid-based membranes, more primitive materials or simple geological processes could have provided compartmentalization on early Earth. In this review, we summarize the current understanding of the types and roles of primitive compartmentalization regarding sustainable replication of genetic molecules, especially from the perspective of the prevention of parasite replication. In addition, we also describe the ability of several environments to selectively accumulate longer genetic molecules, which could also have helped select functional genetic molecules rather than fast-replicating short parasitic molecules.
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spelling doaj.art-51e47a339f4f4aeb85b42cf18c4eee982023-12-03T11:55:34ZengMDPI AGLife2075-17292021-02-0111319110.3390/life11030191Primitive Compartmentalization for the Sustainable Replication of Genetic MoleculesRyo Mizuuchi0Norikazu Ichihashi1Komaba Institute for Science, The University of Tokyo, Meguro, Tokyo 153-8902, JapanKomaba Institute for Science, The University of Tokyo, Meguro, Tokyo 153-8902, JapanSustainable replication and evolution of genetic molecules such as RNA are likely requisites for the emergence of life; however, these processes are easily affected by the appearance of parasitic molecules that replicate by relying on the function of other molecules, while not contributing to their replication. A possible mechanism to repress parasite amplification is compartmentalization that segregates parasitic molecules and limits their access to functional genetic molecules. Although extent cells encapsulate genomes within lipid-based membranes, more primitive materials or simple geological processes could have provided compartmentalization on early Earth. In this review, we summarize the current understanding of the types and roles of primitive compartmentalization regarding sustainable replication of genetic molecules, especially from the perspective of the prevention of parasite replication. In addition, we also describe the ability of several environments to selectively accumulate longer genetic molecules, which could also have helped select functional genetic molecules rather than fast-replicating short parasitic molecules.https://www.mdpi.com/2075-1729/11/3/191origins of lifecompartmentsreplicationevolutionRNAparasites
spellingShingle Ryo Mizuuchi
Norikazu Ichihashi
Primitive Compartmentalization for the Sustainable Replication of Genetic Molecules
Life
origins of life
compartments
replication
evolution
RNA
parasites
title Primitive Compartmentalization for the Sustainable Replication of Genetic Molecules
title_full Primitive Compartmentalization for the Sustainable Replication of Genetic Molecules
title_fullStr Primitive Compartmentalization for the Sustainable Replication of Genetic Molecules
title_full_unstemmed Primitive Compartmentalization for the Sustainable Replication of Genetic Molecules
title_short Primitive Compartmentalization for the Sustainable Replication of Genetic Molecules
title_sort primitive compartmentalization for the sustainable replication of genetic molecules
topic origins of life
compartments
replication
evolution
RNA
parasites
url https://www.mdpi.com/2075-1729/11/3/191
work_keys_str_mv AT ryomizuuchi primitivecompartmentalizationforthesustainablereplicationofgeneticmolecules
AT norikazuichihashi primitivecompartmentalizationforthesustainablereplicationofgeneticmolecules