Neuroprotective Peptides and New Strategies for Ischemic Stroke Drug Discoveries
Ischemic stroke continues to be one of the leading causes of death and disability in the adult population worldwide. The currently used pharmacological methods for the treatment of ischemic stroke are not effective enough and require the search for new tools and approaches to identify therapeutic ta...
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MDPI AG
2023-04-01
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Series: | Genes |
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Online Access: | https://www.mdpi.com/2073-4425/14/5/953 |
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author | Lyudmila V. Dergunova Ivan B. Filippenkov Svetlana A. Limborska Nikolay F. Myasoedov |
author_facet | Lyudmila V. Dergunova Ivan B. Filippenkov Svetlana A. Limborska Nikolay F. Myasoedov |
author_sort | Lyudmila V. Dergunova |
collection | DOAJ |
description | Ischemic stroke continues to be one of the leading causes of death and disability in the adult population worldwide. The currently used pharmacological methods for the treatment of ischemic stroke are not effective enough and require the search for new tools and approaches to identify therapeutic targets and potential neuroprotectors. Today, in the development of neuroprotective drugs for the treatment of stroke, special attention is paid to peptides. Namely, peptide action is aimed at blocking the cascade of pathological processes caused by a decrease in blood flow to the brain tissues. Different groups of peptides have therapeutic potential in ischemia. Among them are small interfering peptides that block protein–protein interactions, cationic arginine-rich peptides with a combination of various neuroprotective properties, shuttle peptides that ensure the permeability of neuroprotectors through the blood–brain barrier, and synthetic peptides that mimic natural regulatory peptides and hormones. In this review, we consider the latest achievements and trends in the development of new biologically active peptides, as well as the role of transcriptomic analysis in identifying the molecular mechanisms of action of potential drugs aimed at the treatment of ischemic stroke. |
first_indexed | 2024-03-11T03:42:34Z |
format | Article |
id | doaj.art-51e4ee61589046b6a356b5edb6406530 |
institution | Directory Open Access Journal |
issn | 2073-4425 |
language | English |
last_indexed | 2024-03-11T03:42:34Z |
publishDate | 2023-04-01 |
publisher | MDPI AG |
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series | Genes |
spelling | doaj.art-51e4ee61589046b6a356b5edb64065302023-11-18T01:28:26ZengMDPI AGGenes2073-44252023-04-0114595310.3390/genes14050953Neuroprotective Peptides and New Strategies for Ischemic Stroke Drug DiscoveriesLyudmila V. Dergunova0Ivan B. Filippenkov1Svetlana A. Limborska2Nikolay F. Myasoedov3Institute of Molecular Genetics, National Research Center “Kurchatov Institute”, Kurchatov Sq. 2, 123182 Moscow, RussiaInstitute of Molecular Genetics, National Research Center “Kurchatov Institute”, Kurchatov Sq. 2, 123182 Moscow, RussiaInstitute of Molecular Genetics, National Research Center “Kurchatov Institute”, Kurchatov Sq. 2, 123182 Moscow, RussiaInstitute of Molecular Genetics, National Research Center “Kurchatov Institute”, Kurchatov Sq. 2, 123182 Moscow, RussiaIschemic stroke continues to be one of the leading causes of death and disability in the adult population worldwide. The currently used pharmacological methods for the treatment of ischemic stroke are not effective enough and require the search for new tools and approaches to identify therapeutic targets and potential neuroprotectors. Today, in the development of neuroprotective drugs for the treatment of stroke, special attention is paid to peptides. Namely, peptide action is aimed at blocking the cascade of pathological processes caused by a decrease in blood flow to the brain tissues. Different groups of peptides have therapeutic potential in ischemia. Among them are small interfering peptides that block protein–protein interactions, cationic arginine-rich peptides with a combination of various neuroprotective properties, shuttle peptides that ensure the permeability of neuroprotectors through the blood–brain barrier, and synthetic peptides that mimic natural regulatory peptides and hormones. In this review, we consider the latest achievements and trends in the development of new biologically active peptides, as well as the role of transcriptomic analysis in identifying the molecular mechanisms of action of potential drugs aimed at the treatment of ischemic stroke.https://www.mdpi.com/2073-4425/14/5/953ischemic strokepeptidespeptide regulationtranscriptomic analysisRNA-Seqbrain |
spellingShingle | Lyudmila V. Dergunova Ivan B. Filippenkov Svetlana A. Limborska Nikolay F. Myasoedov Neuroprotective Peptides and New Strategies for Ischemic Stroke Drug Discoveries Genes ischemic stroke peptides peptide regulation transcriptomic analysis RNA-Seq brain |
title | Neuroprotective Peptides and New Strategies for Ischemic Stroke Drug Discoveries |
title_full | Neuroprotective Peptides and New Strategies for Ischemic Stroke Drug Discoveries |
title_fullStr | Neuroprotective Peptides and New Strategies for Ischemic Stroke Drug Discoveries |
title_full_unstemmed | Neuroprotective Peptides and New Strategies for Ischemic Stroke Drug Discoveries |
title_short | Neuroprotective Peptides and New Strategies for Ischemic Stroke Drug Discoveries |
title_sort | neuroprotective peptides and new strategies for ischemic stroke drug discoveries |
topic | ischemic stroke peptides peptide regulation transcriptomic analysis RNA-Seq brain |
url | https://www.mdpi.com/2073-4425/14/5/953 |
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