Neuroprotective Peptides and New Strategies for Ischemic Stroke Drug Discoveries

Ischemic stroke continues to be one of the leading causes of death and disability in the adult population worldwide. The currently used pharmacological methods for the treatment of ischemic stroke are not effective enough and require the search for new tools and approaches to identify therapeutic ta...

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Main Authors: Lyudmila V. Dergunova, Ivan B. Filippenkov, Svetlana A. Limborska, Nikolay F. Myasoedov
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Genes
Subjects:
Online Access:https://www.mdpi.com/2073-4425/14/5/953
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author Lyudmila V. Dergunova
Ivan B. Filippenkov
Svetlana A. Limborska
Nikolay F. Myasoedov
author_facet Lyudmila V. Dergunova
Ivan B. Filippenkov
Svetlana A. Limborska
Nikolay F. Myasoedov
author_sort Lyudmila V. Dergunova
collection DOAJ
description Ischemic stroke continues to be one of the leading causes of death and disability in the adult population worldwide. The currently used pharmacological methods for the treatment of ischemic stroke are not effective enough and require the search for new tools and approaches to identify therapeutic targets and potential neuroprotectors. Today, in the development of neuroprotective drugs for the treatment of stroke, special attention is paid to peptides. Namely, peptide action is aimed at blocking the cascade of pathological processes caused by a decrease in blood flow to the brain tissues. Different groups of peptides have therapeutic potential in ischemia. Among them are small interfering peptides that block protein–protein interactions, cationic arginine-rich peptides with a combination of various neuroprotective properties, shuttle peptides that ensure the permeability of neuroprotectors through the blood–brain barrier, and synthetic peptides that mimic natural regulatory peptides and hormones. In this review, we consider the latest achievements and trends in the development of new biologically active peptides, as well as the role of transcriptomic analysis in identifying the molecular mechanisms of action of potential drugs aimed at the treatment of ischemic stroke.
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spelling doaj.art-51e4ee61589046b6a356b5edb64065302023-11-18T01:28:26ZengMDPI AGGenes2073-44252023-04-0114595310.3390/genes14050953Neuroprotective Peptides and New Strategies for Ischemic Stroke Drug DiscoveriesLyudmila V. Dergunova0Ivan B. Filippenkov1Svetlana A. Limborska2Nikolay F. Myasoedov3Institute of Molecular Genetics, National Research Center “Kurchatov Institute”, Kurchatov Sq. 2, 123182 Moscow, RussiaInstitute of Molecular Genetics, National Research Center “Kurchatov Institute”, Kurchatov Sq. 2, 123182 Moscow, RussiaInstitute of Molecular Genetics, National Research Center “Kurchatov Institute”, Kurchatov Sq. 2, 123182 Moscow, RussiaInstitute of Molecular Genetics, National Research Center “Kurchatov Institute”, Kurchatov Sq. 2, 123182 Moscow, RussiaIschemic stroke continues to be one of the leading causes of death and disability in the adult population worldwide. The currently used pharmacological methods for the treatment of ischemic stroke are not effective enough and require the search for new tools and approaches to identify therapeutic targets and potential neuroprotectors. Today, in the development of neuroprotective drugs for the treatment of stroke, special attention is paid to peptides. Namely, peptide action is aimed at blocking the cascade of pathological processes caused by a decrease in blood flow to the brain tissues. Different groups of peptides have therapeutic potential in ischemia. Among them are small interfering peptides that block protein–protein interactions, cationic arginine-rich peptides with a combination of various neuroprotective properties, shuttle peptides that ensure the permeability of neuroprotectors through the blood–brain barrier, and synthetic peptides that mimic natural regulatory peptides and hormones. In this review, we consider the latest achievements and trends in the development of new biologically active peptides, as well as the role of transcriptomic analysis in identifying the molecular mechanisms of action of potential drugs aimed at the treatment of ischemic stroke.https://www.mdpi.com/2073-4425/14/5/953ischemic strokepeptidespeptide regulationtranscriptomic analysisRNA-Seqbrain
spellingShingle Lyudmila V. Dergunova
Ivan B. Filippenkov
Svetlana A. Limborska
Nikolay F. Myasoedov
Neuroprotective Peptides and New Strategies for Ischemic Stroke Drug Discoveries
Genes
ischemic stroke
peptides
peptide regulation
transcriptomic analysis
RNA-Seq
brain
title Neuroprotective Peptides and New Strategies for Ischemic Stroke Drug Discoveries
title_full Neuroprotective Peptides and New Strategies for Ischemic Stroke Drug Discoveries
title_fullStr Neuroprotective Peptides and New Strategies for Ischemic Stroke Drug Discoveries
title_full_unstemmed Neuroprotective Peptides and New Strategies for Ischemic Stroke Drug Discoveries
title_short Neuroprotective Peptides and New Strategies for Ischemic Stroke Drug Discoveries
title_sort neuroprotective peptides and new strategies for ischemic stroke drug discoveries
topic ischemic stroke
peptides
peptide regulation
transcriptomic analysis
RNA-Seq
brain
url https://www.mdpi.com/2073-4425/14/5/953
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AT ivanbfilippenkov neuroprotectivepeptidesandnewstrategiesforischemicstrokedrugdiscoveries
AT svetlanaalimborska neuroprotectivepeptidesandnewstrategiesforischemicstrokedrugdiscoveries
AT nikolayfmyasoedov neuroprotectivepeptidesandnewstrategiesforischemicstrokedrugdiscoveries