TRPV1 Hyperfunction Contributes to Renal Inflammation in Oxalate Nephropathy

TRPV1 Hyperfunction Contributes to Renal Inflammation in Oxalate Nephropathy

Inflammation worsens oxalate nephropathy by exacerbating tubular damage. The transient receptor potential vanilloid 1 (TRPV1) channel is present in kidney and has a polymodal sensing ability. Here, we tested whether TRPV1 plays a role in hyperoxaluria-induced renal inflammation. In TRPV1-expressed p...

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Bibliographic Details
Main Authors: Chien-Lin Lu, Te-Yi Teng, Min-Tser Liao, Ming-Chieh Ma
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
TRPV1
arachidonate 12-lipoxygenase
12(<i>S</i>)-HETE
calcium
oxidative stress
inflammasome
Online Access:https://www.mdpi.com/1422-0067/22/12/6204

Internet

https://www.mdpi.com/1422-0067/22/12/6204

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