Development of a Library of Disulfide Bond-Containing Cationic Lipids for mRNA Delivery

Development of a Library of Disulfide Bond-Containing Cationic Lipids for mRNA Delivery

Lipid nanoparticles (LNPs) are the commonly used delivery tools for messenger RNA (mRNA) therapy and play an indispensable role in the success of COVID-19 mRNA vaccines. Ionizable cationic lipids are the most important component in LNPs. Herein, we developed a series of new ionizable lipids featurin...

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Bibliographic Details
Main Authors: Zhigao Shen, Cong Liu, Ziqian Wang, Fengfei Xie, Xingwu Liu, Lingkai Dong, Xuehua Pan, Chen Zeng, Peng George Wang
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceutics
Subjects:
lipid nanoparticles
mRNA delivery
disulfide bond
Online Access:https://www.mdpi.com/1999-4923/15/2/477

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