Characterization of anoikis-based molecular heterogeneity in pancreatic cancer and pancreatic neuroendocrine tumor and its association with tumor immune microenvironment and metabolic remodeling

Characterization of anoikis-based molecular heterogeneity in pancreatic cancer and pancreatic neuroendocrine tumor and its association with tumor immune microenvironment and metabolic remodeling

BackgroundAccumulating evidence suggests that anoikis plays a crucial role in the onset and progression of pancreatic cancer (PC) and pancreatic neuroendocrine tumors (PNETs); nevertheless, the prognostic value and molecular characteristics of anoikis in cancers are yet to be determined.Materials an...

Full description

Bibliographic Details
Main Authors:	Ning Li, Xingqing Jia, Zhong Wang, Kaige Wang, Zumin Qu, Dong Chi, Zhubo Sun, Jian Jiang, Yougang Cui, Changmiao Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-05-01
Series:	Frontiers in Endocrinology
Subjects:	pancreatic adenocarcinoma pancreatic neuroendocrine tumors anoikis molecular characteristics metabolic remodelling tumor immune microenvironment
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2023.1153909/full

Similar Items

Determination and characterization of molecular heterogeneity and precision medicine strategies of patients with pancreatic cancer and pancreatic neuroendocrine tumor based on oxidative stress and mitochondrial dysfunction-related genes
by: Yougang Cui, et al.
Published: (2023-05-01)

Bone Loss in Patients with Pancreatic Neuroendocrine Tumors
by: He Tong, et al.
Published: (2022-11-01)

Treatment Options for Pancreatic Neuroendocrine Tumors
by: Amit Akirov, et al.
Published: (2019-06-01)

PANCREATIC NEUROENDOCRINE TUMORS: SURGICAL RESECTION
by: Marcos BELOTTO, et al.
Published: (2019-02-01)

Clinicopathological features and long-term prognosis of purely cystic pancreatic neuroendocrine tumors: A single-center experience
by: Shu-Jie Ren, et al.
Published: (2023-02-01)

Serum Metabolite Biomarkers for Pancreatic Tumors: Neuroendocrine and Pancreatic Ductal Adenocarcinomas—A Preliminary Study
by: Karolina Skubisz, et al.
Published: (2023-06-01)

An Insight on Functioning Pancreatic Neuroendocrine Neoplasms
by: Michele Bevere, et al.
Published: (2023-01-01)

Pancreatic Divisum Associated with Ampullary Neuroendocrine Tumor and the Role of Magnetic Resonance Imaging
by: Fatma Kulalı, et al.
Published: (2017-09-01)

Medical Treatment of Advanced Pancreatic Neuroendocrine Neoplasms
by: Lola-Jade Palmieri, et al.
Published: (2020-06-01)

Pancreatic Neuroendocrine Tumors: Signaling Pathways and Epigenetic Regulation
by: Zena Saleh, et al.
Published: (2024-01-01)

Pediatric Pancreatic Endocrine Tumor Presenting as Acute Pancreatitis: A Case Report
by: Shigetaka Fukuda, et al.
Published: (2023-05-01)

Surgical Management of Pancreatic Neuroendocrine Tumors
by: Megan L. Sulciner, et al.
Published: (2023-03-01)

Outcomes after Surgery for Malignant Pancreatic Neuroendocrine Tumors
by: Omar Hama Ghalib Azeez Hawramy, et al.
Published: (2019-08-01)

Oncolytic Effect of Zika Virus in Neuroendocrine Pancreatic Tumors: New Perspectives for Therapeutic Approaches
by: Martina Maria Cocco, et al.
Published: (2023-12-01)

Role of Endoscopic Ultrasound in the Diagnosis of Pancreatic Neuroendocrine Neoplasms
by: Tatsuya Ishii, et al.
Published: (2021-02-01)

Pancreatic Neuroendocrine Tumors: Molecular Mechanisms and Therapeutic Targets
by: Chandra K. Maharjan, et al.
Published: (2021-10-01)

Multimodal Management of Grade 1 and 2 Pancreatic Neuroendocrine Tumors
by: Ugo Marchese, et al.
Published: (2022-01-01)

Hyperammonemic Encephalopathy in a Patient with Pancreatic Neuroendocrine Tumor and Portosystemic Shunt
by: Marcel Zorgdrager, et al.
Published: (2023-02-01)

What Are the Place and Modalities of Surgical Management for Pancreatic Neuroendocrine Neoplasms? A Narrative Review
by: Samuel Frey, et al.
Published: (2021-11-01)

The Predictive Value of CT Findings in Invasive Behavior of Pancreatic Neuroendocrine Tumors
by: Xiaoyong CHEN, et al.
Published: (2022-06-01)

Pancreaticoduodenectomy in 11-year-old male with a non-functional pancreatic neuroendocrine tumor
by: Whitney Elks, et al.
Published: (2023-01-01)

Apoptosis-related factors are relevant to progression of pancreatic neuroendocrine tumors
by: Shota Amano, et al.
Published: (2023-12-01)

Characteristics of small pancreatic neuroendocrine tumors and risk factors for invasion and metastasis
by: Wentong Mei, et al.
Published: (2023-03-01)

Molecular biology of pancreatic neuroendocrine tumors: From mechanism to translation
by: Xiaofei Shen, et al.
Published: (2022-09-01)

Identifying Risk Factors and Patterns for Early Recurrence of Pancreatic Neuroendocrine Tumors: A Multi-Institutional Study
by: Charlotte M. Heidsma, et al.
Published: (2021-05-01)

Misdiagnosed cystic pancreatic neuroendocrine tumor with bilobar hepatic metastasis managed with single-stage resection — a case report
by: Maham Nasir Uddin, et al.
Published: (2023-12-01)

Surgical Indications and Outcomes of Resection for Pancreatic Neuroendocrine Tumors with Vascular Involvement
by: Amy Y. Li, et al.
Published: (2022-05-01)

Narrative Review of Immunotherapy in Gastroentero-Pancreatic Neuroendocrine Neoplasms
by: Jasmeet Kaur, et al.
Published: (2023-09-01)

Involvement of Neutrophils in Metastatic Evolution of Pancreatic Neuroendocrine Tumors
by: Véronique Debien, et al.
Published: (2021-06-01)

Epidemiological trends for functional pancreatic neuroendocrine tumors: A study combining multiple imputation with age adjustment
by: Shuaiwu Luo, et al.
Published: (2023-04-01)

The Predicting Role of the Neutrophil-to-Lymphocyte Ratio for the Tumor Grade and Prognosis in Pancreatic Neuroendocrine Tumors
by: Dongwook Oh, et al.
Published: (2022-03-01)

Clinical relevance of different WHO grade 3 pancreatic neuroendocrine neoplasms based on morphology
by: Xu Han, et al.
Published: (2018-02-01)

Age in combination with gender is a valuable parameter in differential diagnosis of solid pseudopapillary tumors and pancreatic neuroendocrine neoplasm
by: Leshuang Wu, et al.
Published: (2022-10-01)

A Lymph Node Ratio Model for Prognosis of Patients with Pancreatic Neuroendocrine Tumors
by: Esther Osher, et al.
Published: (2023-01-01)

Therapy of Pancreatic Neuroendocrine Tumors: Fine Needle Intervention including Ethanol and Radiofrequency Ablation
by: Sundeep Lakhtakia
Published: (2017-11-01)

Biomarkers for Pancreatic Neuroendocrine Neoplasms (PanNENs) Management—An Updated Review
by: Martine Bocchini, et al.
Published: (2020-05-01)

Anoikis-Related Gene Signature for Prognostication of Pancreatic Adenocarcinoma: A Multi-Omics Exploration and Verification Study
by: Jin Zhang, et al.
Published: (2023-06-01)

A duodenal gastrointestinal stromal tumor mimicking a pancreatic neuroendocrine tumor: a case report
by: Masashi Inoue, et al.
Published: (2022-08-01)

The Surgical and Therapeutic Activities of Non-Functional Pancreatic Neuroendocrine Tumors at a High-Volume Institution
by: Wu-Hu Zhang, et al.
Published: (2023-03-01)

The Disproportionate Rise in Pancreatic Cancer in Younger Women Is Due to a Rise in Adenocarcinoma and Not Neuroendocrine Tumors: A Nationwide Time-Trend Analysis Using 2001–2018 United States Cancer Statistics Databases
by: Yi Jiang, et al.
Published: (2024-02-01)