The Effect of Garlic Tablet on Blood Glucose, and Lipid Profile in Type 2 Diabetic Patients: A Double-Blind Randomized Placebo Controlled Trial
Introduction: Diabetes, as one of the most common endocrine disorders, has many different complications and outcomes. Some pieces of evidence proposed that garlic can be useful for diabetic patients due to its various compounds. Therefore, this study aimed to assess the effect of garlic tablet suppl...
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| Format: | Article |
| Language: | fas |
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Shahid Sadoughi University of Medical Sciences
2015-10-01
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| Series: | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd |
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| Online Access: | http://jssu.ssu.ac.ir/browse.php?a_code=A-10-93-4&slc_lang=en&sid=1 |
| _version_ | 1818421678431010816 |
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| author | R Khademian-Ravandi H Mozaffari-Khosravi Alireza Esteghamati AP Meysami |
| author_facet | R Khademian-Ravandi H Mozaffari-Khosravi Alireza Esteghamati AP Meysami |
| author_sort | R Khademian-Ravandi |
| collection | DOAJ |
| description | Introduction: Diabetes, as one of the most common endocrine disorders, has many different complications and outcomes. Some pieces of evidence proposed that garlic can be useful for diabetic patients due to its various compounds. Therefore, this study aimed to assess the effect of garlic tablet supplement on fasting blood sugar (FBS), Glycated hemoglobin A1c(HbA1c) and lipid profile levels in type 2 diabetic patients.
Methods: This double-blind randomized placebo controlled trial was carried out at Imam Khomeini hospital in Tehran. The study sample consisted of 50 diabetic patients, who were randomly divided into two groups of 25 participants: placebo (PG) and garlic group (GG). The GG took three 400mg-garlic tablets and the PG group took 3 tablets similar to the garlic tablets per day after every main meal for 3 months. Lipid profile, HbA1c and FBS concentrations were measured before and after the intervention.
Results: There were not any significant differences in regard with age, gender and disease history between the two groups. After 3 months, the mean of FBS (from 155.23±36.47 to 140.57±44.18 mg/dl,pv=0.05) and HbA1c(from 8.6 %±1.04 to 7.27%±1.21,pv<0.001) decreased significantly in GG in comparison with PG. The mean of HDLc change in GG revealed a significant increase compared to PG (-2.03 vs. 1.76±6.96 mg/dl). Moreover, no other significant differences were observed in regard with other studied variables between the two groups.
Conclusion: The findings of the present study revealed that daily consumption of three 400mg-garlic tablets in diabetic patients can lead to a decrease of FBS and HbA1c, in contrary to an increase of HDLc. As a result, garlic tablet supplement seems to be beneficial to complications control as well as treatment of diabetes. |
| first_indexed | 2024-12-14T13:14:11Z |
| format | Article |
| id | doaj.art-51e746d430ae4476b4bdd708ae24f1b3 |
| institution | Directory Open Access Journal |
| issn | 2228-5741 2228-5733 |
| language | fas |
| last_indexed | 2024-12-14T13:14:11Z |
| publishDate | 2015-10-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd |
| spelling | doaj.art-51e746d430ae4476b4bdd708ae24f1b32022-12-21T23:00:06ZfasShahid Sadoughi University of Medical SciencesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd2228-57412228-57332015-10-01237621630The Effect of Garlic Tablet on Blood Glucose, and Lipid Profile in Type 2 Diabetic Patients: A Double-Blind Randomized Placebo Controlled TrialR Khademian-Ravandi0H Mozaffari-Khosravi1Alireza Esteghamati2AP Meysami3 Shahid Sadoughi University of Medical Sciences Shahid Sadoughi University of Medical Sciences, Yazd, Iran Tehran University of Medical Sciences, Tehran, Iran Tehran University of Medical Sciences, Tehran, Iran Introduction: Diabetes, as one of the most common endocrine disorders, has many different complications and outcomes. Some pieces of evidence proposed that garlic can be useful for diabetic patients due to its various compounds. Therefore, this study aimed to assess the effect of garlic tablet supplement on fasting blood sugar (FBS), Glycated hemoglobin A1c(HbA1c) and lipid profile levels in type 2 diabetic patients. Methods: This double-blind randomized placebo controlled trial was carried out at Imam Khomeini hospital in Tehran. The study sample consisted of 50 diabetic patients, who were randomly divided into two groups of 25 participants: placebo (PG) and garlic group (GG). The GG took three 400mg-garlic tablets and the PG group took 3 tablets similar to the garlic tablets per day after every main meal for 3 months. Lipid profile, HbA1c and FBS concentrations were measured before and after the intervention. Results: There were not any significant differences in regard with age, gender and disease history between the two groups. After 3 months, the mean of FBS (from 155.23±36.47 to 140.57±44.18 mg/dl,pv=0.05) and HbA1c(from 8.6 %±1.04 to 7.27%±1.21,pv<0.001) decreased significantly in GG in comparison with PG. The mean of HDLc change in GG revealed a significant increase compared to PG (-2.03 vs. 1.76±6.96 mg/dl). Moreover, no other significant differences were observed in regard with other studied variables between the two groups. Conclusion: The findings of the present study revealed that daily consumption of three 400mg-garlic tablets in diabetic patients can lead to a decrease of FBS and HbA1c, in contrary to an increase of HDLc. As a result, garlic tablet supplement seems to be beneficial to complications control as well as treatment of diabetes.http://jssu.ssu.ac.ir/browse.php?a_code=A-10-93-4&slc_lang=en&sid=1Fasting blood glucose Garlic tablet HbA1c Lipid profiles Type 2 diabetes |
| spellingShingle | R Khademian-Ravandi H Mozaffari-Khosravi Alireza Esteghamati AP Meysami The Effect of Garlic Tablet on Blood Glucose, and Lipid Profile in Type 2 Diabetic Patients: A Double-Blind Randomized Placebo Controlled Trial Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd Fasting blood glucose Garlic tablet HbA1c Lipid profiles Type 2 diabetes |
| title | The Effect of Garlic Tablet on Blood Glucose, and Lipid Profile in Type 2 Diabetic Patients: A Double-Blind Randomized Placebo Controlled Trial |
| title_full | The Effect of Garlic Tablet on Blood Glucose, and Lipid Profile in Type 2 Diabetic Patients: A Double-Blind Randomized Placebo Controlled Trial |
| title_fullStr | The Effect of Garlic Tablet on Blood Glucose, and Lipid Profile in Type 2 Diabetic Patients: A Double-Blind Randomized Placebo Controlled Trial |
| title_full_unstemmed | The Effect of Garlic Tablet on Blood Glucose, and Lipid Profile in Type 2 Diabetic Patients: A Double-Blind Randomized Placebo Controlled Trial |
| title_short | The Effect of Garlic Tablet on Blood Glucose, and Lipid Profile in Type 2 Diabetic Patients: A Double-Blind Randomized Placebo Controlled Trial |
| title_sort | effect of garlic tablet on blood glucose and lipid profile in type 2 diabetic patients a double blind randomized placebo controlled trial |
| topic | Fasting blood glucose Garlic tablet HbA1c Lipid profiles Type 2 diabetes |
| url | http://jssu.ssu.ac.ir/browse.php?a_code=A-10-93-4&slc_lang=en&sid=1 |
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