Parental occupational exposure to combustion products, metals, silica and asbestos and risk of childhood leukaemia: Findings from the Childhood Cancer and Leukaemia International Consortium (CLIC)
Parental occupational exposures around conception (father) or during pregnancy (mother) have been hypothesized as potential predisposing factors for childhood leukaemia. We investigated parental exposure to several known occupational carcinogens and childhood leukaemia risk. We conducted a pooled an...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412022003361 |
| _version_ | 1811216152931598336 |
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| author | Felix M. Onyije Ann Olsson Friederike Erdmann Corrado Magnani Eleni Petridou Jacqueline Clavel Lucia Miligi Audrey Bonaventure Daniela Ferrante Sara Piro Susan Peters Roel Vermeulen Hans Kromhout Joachim Schüz |
| author_facet | Felix M. Onyije Ann Olsson Friederike Erdmann Corrado Magnani Eleni Petridou Jacqueline Clavel Lucia Miligi Audrey Bonaventure Daniela Ferrante Sara Piro Susan Peters Roel Vermeulen Hans Kromhout Joachim Schüz |
| author_sort | Felix M. Onyije |
| collection | DOAJ |
| description | Parental occupational exposures around conception (father) or during pregnancy (mother) have been hypothesized as potential predisposing factors for childhood leukaemia. We investigated parental exposure to several known occupational carcinogens and childhood leukaemia risk. We conducted a pooled analysis using case-control data from four European countries (3362 childhood leukemia cases and 6268 controls). Parental occupational exposures to polycyclic aromatic hydrocarbons (PAH), diesel engine exhaust (DEE), chromium, nickel, crystalline silica, and asbestos were assessed by a general population job-exposure matrix. We estimated odd ratios (ORs) and 95% confidence intervals (CIs) using unconditional logistic regression models for all childhood leukaemia combined, by leukaemia type (ALL and AML) and by ALL subtype (B-lineage and T-lineage). We found an association between high paternal occupational exposure to crystalline silica and childhood ALL (OR 2.20, CI 1.60–3.01) with increasing trend from no exposure to high exposure (P = <0.001), and also for AML (OR 2.03, CI 1.04–3.97; P for trend = 0.008). ORs were similar for B- and T-lineage ALL. For ALL, ORs were also slightly elevated with wide confidence intervals for high paternal occupational exposure to chromium (OR 1.23, CI 0.77–1.96), and DEE (OR 1.21, CI 0.82–1.77). No associations were observed for paternal exposures to nickel, PAH and asbestos. For maternal occupational exposure we found several slightly elevated odds ratios but mostly with very wide confidence intervals due to low numbers of exposed mothers. This is a first study suggesting an association between fathers’ occupational exposure to crystalline silica and an increased risk of childhood leukaemia in their offspring. As this association was driven by certain occupations (field crop farmers and miners) where other potentially relevant exposures like pesticides and radon may also occur, more research is needed to confirm our findings of an association with crystalline silica, and if so, mechanistic studies to understand the pathways. |
| first_indexed | 2024-04-12T06:33:38Z |
| format | Article |
| id | doaj.art-51e7806d12454108825a1e4be07ca618 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-04-12T06:33:38Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-51e7806d12454108825a1e4be07ca6182022-12-22T03:43:56ZengElsevierEnvironment International0160-41202022-09-01167107409Parental occupational exposure to combustion products, metals, silica and asbestos and risk of childhood leukaemia: Findings from the Childhood Cancer and Leukaemia International Consortium (CLIC)Felix M. Onyije0Ann Olsson1Friederike Erdmann2Corrado Magnani3Eleni Petridou4Jacqueline Clavel5Lucia Miligi6Audrey Bonaventure7Daniela Ferrante8Sara Piro9Susan Peters10Roel Vermeulen11Hans Kromhout12Joachim Schüz13Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), 150 Cours Albert Thomas, 69372 Lyon, FranceEnvironment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), 150 Cours Albert Thomas, 69372 Lyon, FranceEnvironment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), 150 Cours Albert Thomas, 69372 Lyon, France; Division of Childhood Cancer Epidemiology, Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center Mainz, Langenbeckstraβe 1, 55131 Mainz, GermanyDepartment of Translational Medicine, Unit of Medical Statistics, University of Piemonte Orientale and Cancer Epidemiology Unit, CPO Piemonte, Novara, ItalyDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens & Clinical Epidemiology Unit, Athens, GreeceGroup of Epidemiology of Childhood and Adolescent Cancers Team, CRESS UMRS-1153, INSERM, University Paris Cité, Villejuif, France; National Registry of Childhood Cancers, Hôpital Paul Brousse, Groupe Hospitalier Universitaire Paris-Sud, Assistance Publique Hôpitaux de Paris (AP-HP), Villejuif, France; Centre Hospitalier Régional Universitaire de Nancy, Vandoeuvre-lès-Nancy, FranceEnvironmental and Occupational Epidemiology Branch, Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network-ISPRO, Florence, ItalyGroup of Epidemiology of Childhood and Adolescent Cancers Team, CRESS UMRS-1153, INSERM, University Paris Cité, Villejuif, FranceDepartment of Translational Medicine, Unit of Medical Statistics, University of Piemonte Orientale and Cancer Epidemiology Unit, CPO Piemonte, Novara, ItalyEnvironmental and Occupational Epidemiology Branch, Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network-ISPRO, Florence, ItalyInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, the NetherlandsInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, the NetherlandsInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, the NetherlandsEnvironment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), 150 Cours Albert Thomas, 69372 Lyon, FranceParental occupational exposures around conception (father) or during pregnancy (mother) have been hypothesized as potential predisposing factors for childhood leukaemia. We investigated parental exposure to several known occupational carcinogens and childhood leukaemia risk. We conducted a pooled analysis using case-control data from four European countries (3362 childhood leukemia cases and 6268 controls). Parental occupational exposures to polycyclic aromatic hydrocarbons (PAH), diesel engine exhaust (DEE), chromium, nickel, crystalline silica, and asbestos were assessed by a general population job-exposure matrix. We estimated odd ratios (ORs) and 95% confidence intervals (CIs) using unconditional logistic regression models for all childhood leukaemia combined, by leukaemia type (ALL and AML) and by ALL subtype (B-lineage and T-lineage). We found an association between high paternal occupational exposure to crystalline silica and childhood ALL (OR 2.20, CI 1.60–3.01) with increasing trend from no exposure to high exposure (P = <0.001), and also for AML (OR 2.03, CI 1.04–3.97; P for trend = 0.008). ORs were similar for B- and T-lineage ALL. For ALL, ORs were also slightly elevated with wide confidence intervals for high paternal occupational exposure to chromium (OR 1.23, CI 0.77–1.96), and DEE (OR 1.21, CI 0.82–1.77). No associations were observed for paternal exposures to nickel, PAH and asbestos. For maternal occupational exposure we found several slightly elevated odds ratios but mostly with very wide confidence intervals due to low numbers of exposed mothers. This is a first study suggesting an association between fathers’ occupational exposure to crystalline silica and an increased risk of childhood leukaemia in their offspring. As this association was driven by certain occupations (field crop farmers and miners) where other potentially relevant exposures like pesticides and radon may also occur, more research is needed to confirm our findings of an association with crystalline silica, and if so, mechanistic studies to understand the pathways.http://www.sciencedirect.com/science/article/pii/S0160412022003361Childhood leukaemiaParental occupational exposureJob-exposure matrixCrystalline silicaPooled analysis |
| spellingShingle | Felix M. Onyije Ann Olsson Friederike Erdmann Corrado Magnani Eleni Petridou Jacqueline Clavel Lucia Miligi Audrey Bonaventure Daniela Ferrante Sara Piro Susan Peters Roel Vermeulen Hans Kromhout Joachim Schüz Parental occupational exposure to combustion products, metals, silica and asbestos and risk of childhood leukaemia: Findings from the Childhood Cancer and Leukaemia International Consortium (CLIC) Environment International Childhood leukaemia Parental occupational exposure Job-exposure matrix Crystalline silica Pooled analysis |
| title | Parental occupational exposure to combustion products, metals, silica and asbestos and risk of childhood leukaemia: Findings from the Childhood Cancer and Leukaemia International Consortium (CLIC) |
| title_full | Parental occupational exposure to combustion products, metals, silica and asbestos and risk of childhood leukaemia: Findings from the Childhood Cancer and Leukaemia International Consortium (CLIC) |
| title_fullStr | Parental occupational exposure to combustion products, metals, silica and asbestos and risk of childhood leukaemia: Findings from the Childhood Cancer and Leukaemia International Consortium (CLIC) |
| title_full_unstemmed | Parental occupational exposure to combustion products, metals, silica and asbestos and risk of childhood leukaemia: Findings from the Childhood Cancer and Leukaemia International Consortium (CLIC) |
| title_short | Parental occupational exposure to combustion products, metals, silica and asbestos and risk of childhood leukaemia: Findings from the Childhood Cancer and Leukaemia International Consortium (CLIC) |
| title_sort | parental occupational exposure to combustion products metals silica and asbestos and risk of childhood leukaemia findings from the childhood cancer and leukaemia international consortium clic |
| topic | Childhood leukaemia Parental occupational exposure Job-exposure matrix Crystalline silica Pooled analysis |
| url | http://www.sciencedirect.com/science/article/pii/S0160412022003361 |
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