Ultrasound Activated Nanobowls with Deep Penetration for Enhancing Sonodynamic Therapy of Orthotopic Liver Cancer
Abstract Owing to the high penetration ability and the safety of ultrasound (US) of sonodynamic therapy (SDT), it has gained significant attention in tumor treatment. However, its therapeutic efficiency depends on the performance of the sonosensitizers. The hypoxic microenvironment and abnormal stro...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-04-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202306301 |
| _version_ | 1827296612741808128 |
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| author | Xiahui Lin Shan Chen Yina Su Ying Wu Linjie Huang Qin Ye Jibin Song |
| author_facet | Xiahui Lin Shan Chen Yina Su Ying Wu Linjie Huang Qin Ye Jibin Song |
| author_sort | Xiahui Lin |
| collection | DOAJ |
| description | Abstract Owing to the high penetration ability and the safety of ultrasound (US) of sonodynamic therapy (SDT), it has gained significant attention in tumor treatment. However, its therapeutic efficiency depends on the performance of the sonosensitizers. The hypoxic microenvironment and abnormal stromal matrix restrict the full potential of sonosensitizers. In this study, a US‐activated bowl‐shaped nanobomb (APBN) is designed as a novel sonosensitizer to enhance the SDT effect through various means. This enhancement strategy combines three major characteristics: relieving tumor hypoxia, amplifying bubble cavitation damage, and US‐movement‐enhanced permeation. The unique bowl‐shaped structure of APBN provides more favorable attachment sites for the generated oxygen gas bubbles. Thus, when catalase‐like APBN catalyzes endogenous hydrogen peroxide to produce oxygen, bubbles accumulate at the groove, preventing the dissipation of oxygen and increasing the number of cavitation nuclei to improve the acoustic cavitation effect. This approach differs from traditional SDT strategies because it couples the sonodynamic effect with reactive oxygen species generation and bubble cavitation damage rather than a single action. Additionally, the asymmetric bowl‐shaped structure generates a driving force under the US field, improving the distribution of sonosensitizers in the tumors. Using US and photoacoustic imaging for dual localization, these sonosensitizers can improve the accuracy of orthotopic liver tumor treatment, which presents a promising avenue for the treatment of deep tumors. |
| first_indexed | 2024-04-24T14:41:35Z |
| format | Article |
| id | doaj.art-51e82e2e4a524b3897bcc39258211136 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-24T14:41:35Z |
| publishDate | 2024-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-51e82e2e4a524b3897bcc392582111362024-04-02T20:51:56ZengWileyAdvanced Science2198-38442024-04-011113n/an/a10.1002/advs.202306301Ultrasound Activated Nanobowls with Deep Penetration for Enhancing Sonodynamic Therapy of Orthotopic Liver CancerXiahui Lin0Shan Chen1Yina Su2Ying Wu3Linjie Huang4Qin Ye5Jibin Song6School of Medical Imaging Fujian Medical University Fuzhou Fujian 350122 P. R. ChinaCollege of Geography and Ocean Minjiang University Fuzhou 350108 P. R. ChinaSchool of Medical Imaging Fujian Medical University Fuzhou Fujian 350122 P. R. ChinaCollege of Chemistry Beijing University of Chemical Technology Beijing 10010 P. R. ChinaSchool of Medical Imaging Fujian Medical University Fuzhou Fujian 350122 P. R. ChinaDepartment of Ultrasound Union Hospital Fujian Medical University Fujian Institute of Ultrasonic Medicine Fuzhou 350108 P. R. ChinaCollege of Chemistry Beijing University of Chemical Technology Beijing 10010 P. R. ChinaAbstract Owing to the high penetration ability and the safety of ultrasound (US) of sonodynamic therapy (SDT), it has gained significant attention in tumor treatment. However, its therapeutic efficiency depends on the performance of the sonosensitizers. The hypoxic microenvironment and abnormal stromal matrix restrict the full potential of sonosensitizers. In this study, a US‐activated bowl‐shaped nanobomb (APBN) is designed as a novel sonosensitizer to enhance the SDT effect through various means. This enhancement strategy combines three major characteristics: relieving tumor hypoxia, amplifying bubble cavitation damage, and US‐movement‐enhanced permeation. The unique bowl‐shaped structure of APBN provides more favorable attachment sites for the generated oxygen gas bubbles. Thus, when catalase‐like APBN catalyzes endogenous hydrogen peroxide to produce oxygen, bubbles accumulate at the groove, preventing the dissipation of oxygen and increasing the number of cavitation nuclei to improve the acoustic cavitation effect. This approach differs from traditional SDT strategies because it couples the sonodynamic effect with reactive oxygen species generation and bubble cavitation damage rather than a single action. Additionally, the asymmetric bowl‐shaped structure generates a driving force under the US field, improving the distribution of sonosensitizers in the tumors. Using US and photoacoustic imaging for dual localization, these sonosensitizers can improve the accuracy of orthotopic liver tumor treatment, which presents a promising avenue for the treatment of deep tumors.https://doi.org/10.1002/advs.202306301cavitationphotoacoustic imagingsonodynamic therapysonosensitizersultrasound |
| spellingShingle | Xiahui Lin Shan Chen Yina Su Ying Wu Linjie Huang Qin Ye Jibin Song Ultrasound Activated Nanobowls with Deep Penetration for Enhancing Sonodynamic Therapy of Orthotopic Liver Cancer Advanced Science cavitation photoacoustic imaging sonodynamic therapy sonosensitizers ultrasound |
| title | Ultrasound Activated Nanobowls with Deep Penetration for Enhancing Sonodynamic Therapy of Orthotopic Liver Cancer |
| title_full | Ultrasound Activated Nanobowls with Deep Penetration for Enhancing Sonodynamic Therapy of Orthotopic Liver Cancer |
| title_fullStr | Ultrasound Activated Nanobowls with Deep Penetration for Enhancing Sonodynamic Therapy of Orthotopic Liver Cancer |
| title_full_unstemmed | Ultrasound Activated Nanobowls with Deep Penetration for Enhancing Sonodynamic Therapy of Orthotopic Liver Cancer |
| title_short | Ultrasound Activated Nanobowls with Deep Penetration for Enhancing Sonodynamic Therapy of Orthotopic Liver Cancer |
| title_sort | ultrasound activated nanobowls with deep penetration for enhancing sonodynamic therapy of orthotopic liver cancer |
| topic | cavitation photoacoustic imaging sonodynamic therapy sonosensitizers ultrasound |
| url | https://doi.org/10.1002/advs.202306301 |
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