Bayesian penalized model for classification and selection of functional predictors using longitudinal MRI data from ADNI
The main goal of this paper is to employ longitudinal trajectories in a significant number of sub-regional brain volumetric MRI data as statistical predictors for Alzheimer's disease (AD) classification. We use logistic regression in a Bayesian framework that includes many functional predictors...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-11-01
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| Series: | Statistical Theory and Related Fields |
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| Online Access: | http://dx.doi.org/10.1080/24754269.2022.2064611 |
| _version_ | 1797677007300984832 |
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| author | Asish Banik Taps Maiti Andrew Bender |
| author_facet | Asish Banik Taps Maiti Andrew Bender |
| author_sort | Asish Banik |
| collection | DOAJ |
| description | The main goal of this paper is to employ longitudinal trajectories in a significant number of sub-regional brain volumetric MRI data as statistical predictors for Alzheimer's disease (AD) classification. We use logistic regression in a Bayesian framework that includes many functional predictors. The direct sampling of regression coefficients from the Bayesian logistic model is difficult due to its complicated likelihood function. In high-dimensional scenarios, the selection of predictors is paramount with the introduction of either spike-and-slab priors, non-local priors, or Horseshoe priors. We seek to avoid the complicated Metropolis-Hastings approach and to develop an easily implementable Gibbs sampler. In addition, the Bayesian estimation provides proper estimates of the model parameters, which are also useful for building inference. Another advantage of working with logistic regression is that it calculates the log of odds of relative risk for AD compared to normal control based on the selected longitudinal predictors, rather than simply classifying patients based on cross-sectional estimates. Ultimately, however, we combine approaches and use a probability threshold to classify individual patients. We employ 49 functional predictors consisting of volumetric estimates of brain sub-regions, chosen for their established clinical significance. Moreover, the use of spike-and-slab priors ensures that many redundant predictors are dropped from the model. |
| first_indexed | 2024-03-11T22:38:41Z |
| format | Article |
| id | doaj.art-51e876ef4326441aa8db5fb7e46be57b |
| institution | Directory Open Access Journal |
| issn | 2475-4269 2475-4277 |
| language | English |
| last_indexed | 2024-03-11T22:38:41Z |
| publishDate | 2022-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Statistical Theory and Related Fields |
| spelling | doaj.art-51e876ef4326441aa8db5fb7e46be57b2023-09-22T09:19:46ZengTaylor & Francis GroupStatistical Theory and Related Fields2475-42692475-42772022-11-016432734310.1080/24754269.2022.20646112064611Bayesian penalized model for classification and selection of functional predictors using longitudinal MRI data from ADNIAsish Banik0Taps Maiti1Andrew Bender2Department of Statistics & Probability, Michigan State UniversityDepartment of Statistics & Probability, Michigan State UniversityDepartment of Epidemiology & Biostatistics, Department of Neurology & Ophthalmology, Michigan State UniversityThe main goal of this paper is to employ longitudinal trajectories in a significant number of sub-regional brain volumetric MRI data as statistical predictors for Alzheimer's disease (AD) classification. We use logistic regression in a Bayesian framework that includes many functional predictors. The direct sampling of regression coefficients from the Bayesian logistic model is difficult due to its complicated likelihood function. In high-dimensional scenarios, the selection of predictors is paramount with the introduction of either spike-and-slab priors, non-local priors, or Horseshoe priors. We seek to avoid the complicated Metropolis-Hastings approach and to develop an easily implementable Gibbs sampler. In addition, the Bayesian estimation provides proper estimates of the model parameters, which are also useful for building inference. Another advantage of working with logistic regression is that it calculates the log of odds of relative risk for AD compared to normal control based on the selected longitudinal predictors, rather than simply classifying patients based on cross-sectional estimates. Ultimately, however, we combine approaches and use a probability threshold to classify individual patients. We employ 49 functional predictors consisting of volumetric estimates of brain sub-regions, chosen for their established clinical significance. Moreover, the use of spike-and-slab priors ensures that many redundant predictors are dropped from the model.http://dx.doi.org/10.1080/24754269.2022.2064611alzheimer's diseasebasis splinepólya-gamma augmentationbayesian group lassospike-and-slab priorgibbs samplervolumetric mriadni |
| spellingShingle | Asish Banik Taps Maiti Andrew Bender Bayesian penalized model for classification and selection of functional predictors using longitudinal MRI data from ADNI Statistical Theory and Related Fields alzheimer's disease basis spline pólya-gamma augmentation bayesian group lasso spike-and-slab prior gibbs sampler volumetric mri adni |
| title | Bayesian penalized model for classification and selection of functional predictors using longitudinal MRI data from ADNI |
| title_full | Bayesian penalized model for classification and selection of functional predictors using longitudinal MRI data from ADNI |
| title_fullStr | Bayesian penalized model for classification and selection of functional predictors using longitudinal MRI data from ADNI |
| title_full_unstemmed | Bayesian penalized model for classification and selection of functional predictors using longitudinal MRI data from ADNI |
| title_short | Bayesian penalized model for classification and selection of functional predictors using longitudinal MRI data from ADNI |
| title_sort | bayesian penalized model for classification and selection of functional predictors using longitudinal mri data from adni |
| topic | alzheimer's disease basis spline pólya-gamma augmentation bayesian group lasso spike-and-slab prior gibbs sampler volumetric mri adni |
| url | http://dx.doi.org/10.1080/24754269.2022.2064611 |
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