Serum betatrophin level increased in subjects with metabolic syndrome: a case-control study
Background: Betatrophin is a novel adipokine that provokes pancreatic β-cell proliferation and is involved in lipid metabolism. Aims: This study aims to evaluate the role of serum betatrophin in metabolic syndrome (MetS). Methods: A hospital-based, age-/gender-matched case control study was conducte...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Arán Ediciones, S. L.
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| Series: | Nutrición Hospitalaria |
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| Online Access: | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112016000200019&lng=en&tlng=en |
| _version_ | 1818989012315013120 |
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| author | Zhu Jin-Zhou Li Chun-Xiao Dai Yi-Ning Zhao De-Jian Fang Zhi-Yun Wan Xing-Yong Zhu Hua-Tuo Wang Yu-Ming Yu Chao-Hui Li You-Ming |
| author_facet | Zhu Jin-Zhou Li Chun-Xiao Dai Yi-Ning Zhao De-Jian Fang Zhi-Yun Wan Xing-Yong Zhu Hua-Tuo Wang Yu-Ming Yu Chao-Hui Li You-Ming |
| author_sort | Zhu Jin-Zhou |
| collection | DOAJ |
| description | Background: Betatrophin is a novel adipokine that provokes pancreatic β-cell proliferation and is involved in lipid metabolism. Aims: This study aims to evaluate the role of serum betatrophin in metabolic syndrome (MetS). Methods: A hospital-based, age-/gender-matched case control study was conducted. The serum betatrophin level was evaluated by enzyme-linked immunosorbent assay. Serum concentrations of 12 adipokines were measured to assess their associations with serum betatrophin, using commercial Adipokine Magnetic Bead Panel kits. Statistical analyses included bivariate correlation, receiver operating characteristic (ROC) curve, and multivariate stepwise linear regression. Results: Serum betatrophin showed a higher level in MetS patients (997.36 ± 475.92 pg/ml, p = 0.001) compared with controls (735.35 ± 526.51 pg/ml). Compared with the lowest tertile, the highest tertile of serum betatrophin level indicated an association with higher risk of MetS (adjusted odds ratio = 3.521, 95% confidence interval [CI] [1.191-10.413], p = 0.023). ROC curve of betatrophin was developed to predict the presence of MetS (area under ROC = 0.682 [95% CI, 0.597-0.767], p < 0.001). Furthermore, betatrophin correlated with several parameters, e.g. age (r = 0.286, p < 0.001), body mass index (r = 0.160, p = 0.046), waist-to-hip ratio (r = 0.241, p = 0.002), high-density lipoprotein cholesterol (r = -0.167, p = 0.037), low-density lipoprotein cholesterol (r = -0.195, p = 0.015), fasting plasma glucose (r = 0.266, p = 0.001), hemoglobin A1C (r = 0.314, p < 0.001), homeostasis model assessment of insulin resistance (r = 0.272, p = 0.001), and various adipokines, e.g. resistin (r = 0. 571, p < 0.001), interleukin-8 (r = 0.435, p < 0.001), tumor necrosis factor-α (r = 0.295, p = 0.011) and lipocalin-2 (r = 0.346, p = 0.003). Conclusions: This study supports that serum betatrophin plays an important role in MetS, involving the regulations of glucose and lipid metabolism and inflammation. |
| first_indexed | 2024-12-20T19:31:42Z |
| format | Article |
| id | doaj.art-51e99a392d244c539bf334ee9c1190c8 |
| institution | Directory Open Access Journal |
| issn | 0212-1611 |
| language | English |
| last_indexed | 2024-12-20T19:31:42Z |
| publisher | Arán Ediciones, S. L. |
| record_format | Article |
| series | Nutrición Hospitalaria |
| spelling | doaj.art-51e99a392d244c539bf334ee9c1190c82022-12-21T19:28:46ZengArán Ediciones, S. L.Nutrición Hospitalaria0212-161133230330910.20960/nh.108S0212-16112016000200019Serum betatrophin level increased in subjects with metabolic syndrome: a case-control studyZhu Jin-Zhou0Li Chun-Xiao1Dai Yi-Ning2Zhao De-Jian3Fang Zhi-Yun4Wan Xing-Yong5Zhu Hua-Tuo6Wang Yu-Ming7Yu Chao-Hui8Li You-Ming9The First Affiliated HospitalThe First Affiliated HospitalThe First Affiliated HospitalZhejiang UniversityThe First Affiliated HospitalThe First Affiliated HospitalThe First Affiliated HospitalThe First Affiliated HospitalThe First Affiliated HospitalThe First Affiliated HospitalBackground: Betatrophin is a novel adipokine that provokes pancreatic β-cell proliferation and is involved in lipid metabolism. Aims: This study aims to evaluate the role of serum betatrophin in metabolic syndrome (MetS). Methods: A hospital-based, age-/gender-matched case control study was conducted. The serum betatrophin level was evaluated by enzyme-linked immunosorbent assay. Serum concentrations of 12 adipokines were measured to assess their associations with serum betatrophin, using commercial Adipokine Magnetic Bead Panel kits. Statistical analyses included bivariate correlation, receiver operating characteristic (ROC) curve, and multivariate stepwise linear regression. Results: Serum betatrophin showed a higher level in MetS patients (997.36 ± 475.92 pg/ml, p = 0.001) compared with controls (735.35 ± 526.51 pg/ml). Compared with the lowest tertile, the highest tertile of serum betatrophin level indicated an association with higher risk of MetS (adjusted odds ratio = 3.521, 95% confidence interval [CI] [1.191-10.413], p = 0.023). ROC curve of betatrophin was developed to predict the presence of MetS (area under ROC = 0.682 [95% CI, 0.597-0.767], p < 0.001). Furthermore, betatrophin correlated with several parameters, e.g. age (r = 0.286, p < 0.001), body mass index (r = 0.160, p = 0.046), waist-to-hip ratio (r = 0.241, p = 0.002), high-density lipoprotein cholesterol (r = -0.167, p = 0.037), low-density lipoprotein cholesterol (r = -0.195, p = 0.015), fasting plasma glucose (r = 0.266, p = 0.001), hemoglobin A1C (r = 0.314, p < 0.001), homeostasis model assessment of insulin resistance (r = 0.272, p = 0.001), and various adipokines, e.g. resistin (r = 0. 571, p < 0.001), interleukin-8 (r = 0.435, p < 0.001), tumor necrosis factor-α (r = 0.295, p = 0.011) and lipocalin-2 (r = 0.346, p = 0.003). Conclusions: This study supports that serum betatrophin plays an important role in MetS, involving the regulations of glucose and lipid metabolism and inflammation.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112016000200019&lng=en&tlng=enBetatrofinaAngiopoyetina-8 (ANGPTL8)AdipoquinaHepatoquinaSíndrome metabólico |
| spellingShingle | Zhu Jin-Zhou Li Chun-Xiao Dai Yi-Ning Zhao De-Jian Fang Zhi-Yun Wan Xing-Yong Zhu Hua-Tuo Wang Yu-Ming Yu Chao-Hui Li You-Ming Serum betatrophin level increased in subjects with metabolic syndrome: a case-control study Nutrición Hospitalaria Betatrofina Angiopoyetina-8 (ANGPTL8) Adipoquina Hepatoquina Síndrome metabólico |
| title | Serum betatrophin level increased in subjects with metabolic syndrome: a case-control study |
| title_full | Serum betatrophin level increased in subjects with metabolic syndrome: a case-control study |
| title_fullStr | Serum betatrophin level increased in subjects with metabolic syndrome: a case-control study |
| title_full_unstemmed | Serum betatrophin level increased in subjects with metabolic syndrome: a case-control study |
| title_short | Serum betatrophin level increased in subjects with metabolic syndrome: a case-control study |
| title_sort | serum betatrophin level increased in subjects with metabolic syndrome a case control study |
| topic | Betatrofina Angiopoyetina-8 (ANGPTL8) Adipoquina Hepatoquina Síndrome metabólico |
| url | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112016000200019&lng=en&tlng=en |
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