Combined effects of angiotensin receptor blocker use and physical training in hypertensive men
Purpose Pharmacological (angiotensin II receptor type 1 receptor blocker use) and non-pharmacological treatment (physical aerobic exercise) are important strategies to reduces blood pressure and control arterial hypertension; however, only few clinical studies have evaluated their combined effects o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-05-01
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| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2022.2055763 |
| _version_ | 1797681094497140736 |
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| author | Tábata de Paula Facioli Stella Vieira Philbois Bruno Augusto Aguilar Ana Catarine Veiga Hugo Celso Dutra de Souza |
| author_facet | Tábata de Paula Facioli Stella Vieira Philbois Bruno Augusto Aguilar Ana Catarine Veiga Hugo Celso Dutra de Souza |
| author_sort | Tábata de Paula Facioli |
| collection | DOAJ |
| description | Purpose Pharmacological (angiotensin II receptor type 1 receptor blocker use) and non-pharmacological treatment (physical aerobic exercise) are important strategies to reduces blood pressure and control arterial hypertension; however, only few clinical studies have evaluated their combined effects on autonomic cardiovascular control. Therefore, we investigated the effect of a combination intervention that involved losartan administration and physical aerobic training on autonomic cardiovascular control. Methods Thirty-two men (aged 40 to 60 years) were assigned into two groups: normotensive group, without any pharmacological treatment (NG, N = 16), or hypertensive group, with losartan administration (HG, N = 16). They underwent a physical aerobic training for 16 weeks, thrice a week. Hemodynamic parameters, heart rate variability (HRV), blood pressure variability, and spontaneous baroreflex sensitivity (BRS) were measured before and after training. Results Before training, both the groups showed similar values of hemodynamic parameters. However, the HG showed decreased BRS and HRV, characterized by reduction in sympathetic (p = .02) and vagal (p < .001) modulation. After training, the NG exhibited decreased heart rate (HR) at rest (p < .001), whereas the HG showed decreased HR at rest (p < .001) and blood pressure (BP) (p = .001). The HG showed decreased sympathetic modulation (p = .02) and increased BRS (p < .001) and vagal modulation (p < .001), but HRV (p < .001) and BRS gain (p < .001) remained significantly lower when compared to the NG. Conclusions Physical aerobic training was essential to improve the BRS and HRV cardiac autonomic modulation in the HG. However, it was not sufficient to normalize the analyzed autonomic parameters. |
| first_indexed | 2024-03-11T23:39:53Z |
| format | Article |
| id | doaj.art-51e9c2e780414b259c7228a35c899f54 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:39:53Z |
| publishDate | 2022-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-51e9c2e780414b259c7228a35c899f542023-09-19T16:04:07ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062022-05-0144437238110.1080/10641963.2022.20557632055763Combined effects of angiotensin receptor blocker use and physical training in hypertensive menTábata de Paula Facioli0Stella Vieira Philbois1Bruno Augusto Aguilar2Ana Catarine Veiga3Hugo Celso Dutra de Souza4University of São PauloUniversity of São PauloUniversity of São PauloUniversity of São PauloUniversity of São PauloPurpose Pharmacological (angiotensin II receptor type 1 receptor blocker use) and non-pharmacological treatment (physical aerobic exercise) are important strategies to reduces blood pressure and control arterial hypertension; however, only few clinical studies have evaluated their combined effects on autonomic cardiovascular control. Therefore, we investigated the effect of a combination intervention that involved losartan administration and physical aerobic training on autonomic cardiovascular control. Methods Thirty-two men (aged 40 to 60 years) were assigned into two groups: normotensive group, without any pharmacological treatment (NG, N = 16), or hypertensive group, with losartan administration (HG, N = 16). They underwent a physical aerobic training for 16 weeks, thrice a week. Hemodynamic parameters, heart rate variability (HRV), blood pressure variability, and spontaneous baroreflex sensitivity (BRS) were measured before and after training. Results Before training, both the groups showed similar values of hemodynamic parameters. However, the HG showed decreased BRS and HRV, characterized by reduction in sympathetic (p = .02) and vagal (p < .001) modulation. After training, the NG exhibited decreased heart rate (HR) at rest (p < .001), whereas the HG showed decreased HR at rest (p < .001) and blood pressure (BP) (p = .001). The HG showed decreased sympathetic modulation (p = .02) and increased BRS (p < .001) and vagal modulation (p < .001), but HRV (p < .001) and BRS gain (p < .001) remained significantly lower when compared to the NG. Conclusions Physical aerobic training was essential to improve the BRS and HRV cardiac autonomic modulation in the HG. However, it was not sufficient to normalize the analyzed autonomic parameters.http://dx.doi.org/10.1080/10641963.2022.2055763angiotensinautonomic nervous systemcardiorespiratory fitnesshypertensionlosartan |
| spellingShingle | Tábata de Paula Facioli Stella Vieira Philbois Bruno Augusto Aguilar Ana Catarine Veiga Hugo Celso Dutra de Souza Combined effects of angiotensin receptor blocker use and physical training in hypertensive men Clinical and Experimental Hypertension angiotensin autonomic nervous system cardiorespiratory fitness hypertension losartan |
| title | Combined effects of angiotensin receptor blocker use and physical training in hypertensive men |
| title_full | Combined effects of angiotensin receptor blocker use and physical training in hypertensive men |
| title_fullStr | Combined effects of angiotensin receptor blocker use and physical training in hypertensive men |
| title_full_unstemmed | Combined effects of angiotensin receptor blocker use and physical training in hypertensive men |
| title_short | Combined effects of angiotensin receptor blocker use and physical training in hypertensive men |
| title_sort | combined effects of angiotensin receptor blocker use and physical training in hypertensive men |
| topic | angiotensin autonomic nervous system cardiorespiratory fitness hypertension losartan |
| url | http://dx.doi.org/10.1080/10641963.2022.2055763 |
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