CD146+ Endometrial-Derived Mesenchymal Stem/Stromal Cell Subpopulation Possesses Exosomal Secretomes with Strong Immunomodulatory miRNA Attributes

CD146+ Endometrial-Derived Mesenchymal Stem/Stromal Cell Subpopulation Possesses Exosomal Secretomes with Strong Immunomodulatory miRNA Attributes

The perivascular localization of endometrial mesenchymal stem/stromal cells (eMSC) allows them to sense local and distant tissue damage, promoting tissue repair and healing. Our hypothesis is that eMSC therapeutic effects are largely exerted via their exosomal secretome (eMSC EXOs) by targeting the...

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Bibliographic Details
Main Authors: Clarissa Leñero, Lee D. Kaplan, Thomas M. Best, Dimitrios Kouroupis
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cells
Subjects:
mesenchymal stem/stromal cells (MSCs)
CD146 immunoselection
endometrium
exosomes
miRNAs
immunomodulation
Online Access:https://www.mdpi.com/2073-4409/11/24/4002

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