Recent Advancements in the Loading and Modification of Therapeutic Exosomes
Exosomes have a rapid development of bio-nanoparticles for drug delivery and confluent advances in next-generation diagnostics, monitoring the progression of several diseases, and accurate guidance for therapy. Based on their prominent stability, cargo-carriage properties, stable circulating capabil...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2020.586130/full |
| _version_ | 1818870658793209856 |
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| author | Mengqiao Xu Mengqiao Xu Mengqiao Xu Mengqiao Xu Mengqiao Xu Qianhao Yang Xiaodong Sun Xiaodong Sun Xiaodong Sun Xiaodong Sun Xiaodong Sun Yue Wang Yue Wang |
| author_facet | Mengqiao Xu Mengqiao Xu Mengqiao Xu Mengqiao Xu Mengqiao Xu Qianhao Yang Xiaodong Sun Xiaodong Sun Xiaodong Sun Xiaodong Sun Xiaodong Sun Yue Wang Yue Wang |
| author_sort | Mengqiao Xu |
| collection | DOAJ |
| description | Exosomes have a rapid development of bio-nanoparticles for drug delivery and confluent advances in next-generation diagnostics, monitoring the progression of several diseases, and accurate guidance for therapy. Based on their prominent stability, cargo-carriage properties, stable circulating capability, and favorable safety profile, exosomes have great potential to regulate cellular communication by carrying variable cargoes into specific site. However, the specific loading strategies and modification methods for engineered exosomes to enhance the targeting ability are unclear. The clinical application of exosomes is still limited. In this review, we discuss both original and modified exosomes for loading specific therapeutic molecules (proteins, nucleic acids, and small molecules) and the design strategies used to target specific cells. This review can be used as a reference for further loading and modification strategies as well as for the therapeutic applications of exosomes. |
| first_indexed | 2024-12-19T12:10:32Z |
| format | Article |
| id | doaj.art-51ed6a27b27249f5ab453f72772fb68f |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-19T12:10:32Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-51ed6a27b27249f5ab453f72772fb68f2022-12-21T20:22:13ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852020-11-01810.3389/fbioe.2020.586130586130Recent Advancements in the Loading and Modification of Therapeutic ExosomesMengqiao Xu0Mengqiao Xu1Mengqiao Xu2Mengqiao Xu3Mengqiao Xu4Qianhao Yang5Xiaodong Sun6Xiaodong Sun7Xiaodong Sun8Xiaodong Sun9Xiaodong Sun10Yue Wang11Yue Wang12Shanghai General Hospital, Shanghai, ChinaNational Clinical Research Center for Eye Diseases, Shanghai, ChinaShanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, ChinaShanghai Engineering Center for Visual Science and Photomedicine, Shanghai, ChinaShanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, ChinaDepartment of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, ChinaShanghai General Hospital, Shanghai, ChinaNational Clinical Research Center for Eye Diseases, Shanghai, ChinaShanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, ChinaShanghai Engineering Center for Visual Science and Photomedicine, Shanghai, ChinaShanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, ChinaDepartment of Histology and Embryology, Second Military Medical University, Shanghai, ChinaShanghai Key Lab of Cell Engineering, Shanghai, ChinaExosomes have a rapid development of bio-nanoparticles for drug delivery and confluent advances in next-generation diagnostics, monitoring the progression of several diseases, and accurate guidance for therapy. Based on their prominent stability, cargo-carriage properties, stable circulating capability, and favorable safety profile, exosomes have great potential to regulate cellular communication by carrying variable cargoes into specific site. However, the specific loading strategies and modification methods for engineered exosomes to enhance the targeting ability are unclear. The clinical application of exosomes is still limited. In this review, we discuss both original and modified exosomes for loading specific therapeutic molecules (proteins, nucleic acids, and small molecules) and the design strategies used to target specific cells. This review can be used as a reference for further loading and modification strategies as well as for the therapeutic applications of exosomes.https://www.frontiersin.org/articles/10.3389/fbioe.2020.586130/fullexosomedrug deliveryengineering strategycontent loadingsurface modification |
| spellingShingle | Mengqiao Xu Mengqiao Xu Mengqiao Xu Mengqiao Xu Mengqiao Xu Qianhao Yang Xiaodong Sun Xiaodong Sun Xiaodong Sun Xiaodong Sun Xiaodong Sun Yue Wang Yue Wang Recent Advancements in the Loading and Modification of Therapeutic Exosomes Frontiers in Bioengineering and Biotechnology exosome drug delivery engineering strategy content loading surface modification |
| title | Recent Advancements in the Loading and Modification of Therapeutic Exosomes |
| title_full | Recent Advancements in the Loading and Modification of Therapeutic Exosomes |
| title_fullStr | Recent Advancements in the Loading and Modification of Therapeutic Exosomes |
| title_full_unstemmed | Recent Advancements in the Loading and Modification of Therapeutic Exosomes |
| title_short | Recent Advancements in the Loading and Modification of Therapeutic Exosomes |
| title_sort | recent advancements in the loading and modification of therapeutic exosomes |
| topic | exosome drug delivery engineering strategy content loading surface modification |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2020.586130/full |
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