Polyene phosphatidylcholine enhances the therapeutic response of oxaliplatin in gastric cancer through Nrf2/HMOX1 mediated ferroptosis

Polyene phosphatidylcholine enhances the therapeutic response of oxaliplatin in gastric cancer through Nrf2/HMOX1 mediated ferroptosis

Oxaliplatin (OXA)-based chemotherapy is one of the first-line treatments for advanced gastric cancer. However, the potential risk for chemotherapy-induced hepatic injury can hinder its effectiveness. Polyene phosphatidylcholine (PPC) is often used as a hepatoprotective agent to counter OXA-induced h...

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Bibliographic Details
Main Authors:	Peijie Lei, Lianjing Cao, Hongjun Zhang, Jialei Fu, Xiaojuan Wei, Fei Zhou, Jingjing Cheng, Jie Ming, Haijun Lu, Tao Jiang
Format:	Article
Language:	English
Published:	Elsevier 2024-05-01
Series:	Translational Oncology
Subjects:	Gastric cancer Polyene phosphatidylcholine Ferroptosis Oxaliplatin
Online Access:	http://www.sciencedirect.com/science/article/pii/S1936523324000366

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