Abnormal functional connectivity in the habenula is associated with subjective hyperarousal state in chronic insomnia disorder
BackgroundThe hyperarousal process model plays a central role in the physiology of chronic insomnia disorder (CID). Recent evidence has demonstrated that the habenula is involved in the arousal and sleep–wake cycle. However, whether the intrinsic habenular functional network contributes to the under...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1119595/full |
| _version_ | 1797768762056769536 |
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| author | Liang Gong Fang Cheng Xue Li Zhiqi Wang Shuo Wang Ronghua Xu Bei Zhang Chunhua Xi |
| author_facet | Liang Gong Fang Cheng Xue Li Zhiqi Wang Shuo Wang Ronghua Xu Bei Zhang Chunhua Xi |
| author_sort | Liang Gong |
| collection | DOAJ |
| description | BackgroundThe hyperarousal process model plays a central role in the physiology of chronic insomnia disorder (CID). Recent evidence has demonstrated that the habenula is involved in the arousal and sleep–wake cycle. However, whether the intrinsic habenular functional network contributes to the underlying mechanism of CID and its relationship to the arousal state in CID remains unclear.MethodsThis single-centered study included 34 patients with subjective CID and 22 matched good sleep control (GSC), and underwent a series of neuropsychological tests and resting-state functional magnetic resonance imaging scans. The habenular functional network was assessed using seed-based functional connectivity (FC) analysis. The subjective arousal state was evaluated with the hyperarousal scale (HAS). Alterations in the habenular FC network and their clinical significance in patients with CID were explored.ResultsCompared with the GSC group, the CID group showed decreased habenular FC in the left caudate nucleus and right inferior parietal lobule and increased FC in the right habenula, bilateral calcarine cortex, and posterior cingulate cortex. The decreased FC between the left habenula and caudate nucleus was associated with an increased arousal state in the CID group.ConclusionThe present results provide evidence for a dysfunctional habenular network in patients with CID. These findings extend our understanding of the neuropathological mechanisms underlying the hyperarousal model in chronic insomnia. |
| first_indexed | 2024-03-12T20:58:56Z |
| format | Article |
| id | doaj.art-51f0d61de9114bfbbc32bee52327fd2c |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-12T20:58:56Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-51f0d61de9114bfbbc32bee52327fd2c2023-07-31T11:05:00ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-07-011410.3389/fneur.2023.11195951119595Abnormal functional connectivity in the habenula is associated with subjective hyperarousal state in chronic insomnia disorderLiang Gong0Fang Cheng1Xue Li2Zhiqi Wang3Shuo Wang4Ronghua Xu5Bei Zhang6Chunhua Xi7Department of Neurology, Chengdu Second People’s Hospital, Chengdu, Sichuan, ChinaDepartment of Neurology, The Third Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Neurology, The Third Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Neurology, The Third Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Neurology, The Third Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Neurology, Chengdu Second People’s Hospital, Chengdu, Sichuan, ChinaDepartment of Neurology, Chengdu Second People’s Hospital, Chengdu, Sichuan, ChinaDepartment of Neurology, The Third Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaBackgroundThe hyperarousal process model plays a central role in the physiology of chronic insomnia disorder (CID). Recent evidence has demonstrated that the habenula is involved in the arousal and sleep–wake cycle. However, whether the intrinsic habenular functional network contributes to the underlying mechanism of CID and its relationship to the arousal state in CID remains unclear.MethodsThis single-centered study included 34 patients with subjective CID and 22 matched good sleep control (GSC), and underwent a series of neuropsychological tests and resting-state functional magnetic resonance imaging scans. The habenular functional network was assessed using seed-based functional connectivity (FC) analysis. The subjective arousal state was evaluated with the hyperarousal scale (HAS). Alterations in the habenular FC network and their clinical significance in patients with CID were explored.ResultsCompared with the GSC group, the CID group showed decreased habenular FC in the left caudate nucleus and right inferior parietal lobule and increased FC in the right habenula, bilateral calcarine cortex, and posterior cingulate cortex. The decreased FC between the left habenula and caudate nucleus was associated with an increased arousal state in the CID group.ConclusionThe present results provide evidence for a dysfunctional habenular network in patients with CID. These findings extend our understanding of the neuropathological mechanisms underlying the hyperarousal model in chronic insomnia.https://www.frontiersin.org/articles/10.3389/fneur.2023.1119595/fullinsomnia disorderhabenulahyperarousalfunctional connectivitycaudate nucleus |
| spellingShingle | Liang Gong Fang Cheng Xue Li Zhiqi Wang Shuo Wang Ronghua Xu Bei Zhang Chunhua Xi Abnormal functional connectivity in the habenula is associated with subjective hyperarousal state in chronic insomnia disorder Frontiers in Neurology insomnia disorder habenula hyperarousal functional connectivity caudate nucleus |
| title | Abnormal functional connectivity in the habenula is associated with subjective hyperarousal state in chronic insomnia disorder |
| title_full | Abnormal functional connectivity in the habenula is associated with subjective hyperarousal state in chronic insomnia disorder |
| title_fullStr | Abnormal functional connectivity in the habenula is associated with subjective hyperarousal state in chronic insomnia disorder |
| title_full_unstemmed | Abnormal functional connectivity in the habenula is associated with subjective hyperarousal state in chronic insomnia disorder |
| title_short | Abnormal functional connectivity in the habenula is associated with subjective hyperarousal state in chronic insomnia disorder |
| title_sort | abnormal functional connectivity in the habenula is associated with subjective hyperarousal state in chronic insomnia disorder |
| topic | insomnia disorder habenula hyperarousal functional connectivity caudate nucleus |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1119595/full |
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