A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells

A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells

Summary: Paraspeckles are membraneless organelles formed through liquid-liquid phase separation and consist of multiple proteins and RNAs, including NONO, SFPQ, and NEAT1. The role of paraspeckles and the component NONO in hematopoiesis remains unknown. In this study, we show histone modifier ASXL1...

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Bibliographic Details
Main Authors: Keita Yamamoto, Susumu Goyama, Shuhei Asada, Takeshi Fujino, Taishi Yonezawa, Naru Sato, Reina Takeda, Akiho Tsuchiya, Tomofusa Fukuyama, Yosuke Tanaka, Akihiko Yokoyama, Hikaru Toya, Ayana Kon, Yasuhito Nannya, Rena Onoguchi-Mizutani, Shinichi Nakagawa, Tetsuro Hirose, Seishi Ogawa, Nobuyoshi Akimitsu, Toshio Kitamura
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Cell Reports
Subjects:
ASXL1
LLPS
phase separation
hematopoiesis
HSC
MDS
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472101010X

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