Multi-Detector Characterization of Grape Seed Extract to Enable in silico Safety Assessment
Demands for increased analytical rigor have been growing within the botanical and dietary supplement industry due to concerns relative to safety, efficacy, and quality. Adulteration, ambiguous definitions, and insufficient perspective on safety are some of the major issues that arise when selecting...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-08-01
|
| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fchem.2018.00334/full |
| _version_ | 1818155149414105088 |
|---|---|
| author | Vincent P. Sica Catherine Mahony Timothy R. Baker |
| author_facet | Vincent P. Sica Catherine Mahony Timothy R. Baker |
| author_sort | Vincent P. Sica |
| collection | DOAJ |
| description | Demands for increased analytical rigor have been growing within the botanical and dietary supplement industry due to concerns relative to safety, efficacy, and quality. Adulteration, ambiguous definitions, and insufficient perspective on safety are some of the major issues that arise when selecting a botanical extract. Herein, our comprehensive analytical approach is detailed for the selection of grape seed extracts. This approach provided characterization for the constituents above a threshold of toxicological concern by subjecting the extract to UHPLC-UV-CAD-HRMS and GC-FID & GC-HRMS. Thus, constituents within a wide range of volatility were evaluated. Furthermore, the extract was compared to authenticated botanical materials to confirm that no adulteration took place and was also compared to other grape seed extract sources to confirm that the material falls within the general profile. Finally, these data were cleared via an in silico safety assessment based on the list of constituents above the threshold of toxicological concern. |
| first_indexed | 2024-12-11T14:37:49Z |
| format | Article |
| id | doaj.art-51f299a6ec7a47f4834e80eb7820d37c |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-11T14:37:49Z |
| publishDate | 2018-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-51f299a6ec7a47f4834e80eb7820d37c2022-12-22T01:02:04ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462018-08-01610.3389/fchem.2018.00334363787Multi-Detector Characterization of Grape Seed Extract to Enable in silico Safety AssessmentVincent P. Sica0Catherine Mahony1Timothy R. Baker2Corporate Functions Analytical, The Procter & Gamble Company, Mason, OH, United StatesCentral Product Safety, The Procter & Gamble Company Technical Centres Ltd, Egham, United KingdomCorporate Functions Analytical, The Procter & Gamble Company, Mason, OH, United StatesDemands for increased analytical rigor have been growing within the botanical and dietary supplement industry due to concerns relative to safety, efficacy, and quality. Adulteration, ambiguous definitions, and insufficient perspective on safety are some of the major issues that arise when selecting a botanical extract. Herein, our comprehensive analytical approach is detailed for the selection of grape seed extracts. This approach provided characterization for the constituents above a threshold of toxicological concern by subjecting the extract to UHPLC-UV-CAD-HRMS and GC-FID & GC-HRMS. Thus, constituents within a wide range of volatility were evaluated. Furthermore, the extract was compared to authenticated botanical materials to confirm that no adulteration took place and was also compared to other grape seed extract sources to confirm that the material falls within the general profile. Finally, these data were cleared via an in silico safety assessment based on the list of constituents above the threshold of toxicological concern.https://www.frontiersin.org/article/10.3389/fchem.2018.00334/fullVitis viniferagrape seeddietary supplementsoligomeric proanthocyanidinstanninsthreshold of toxicological concern |
| spellingShingle | Vincent P. Sica Catherine Mahony Timothy R. Baker Multi-Detector Characterization of Grape Seed Extract to Enable in silico Safety Assessment Frontiers in Chemistry Vitis vinifera grape seed dietary supplements oligomeric proanthocyanidins tannins threshold of toxicological concern |
| title | Multi-Detector Characterization of Grape Seed Extract to Enable in silico Safety Assessment |
| title_full | Multi-Detector Characterization of Grape Seed Extract to Enable in silico Safety Assessment |
| title_fullStr | Multi-Detector Characterization of Grape Seed Extract to Enable in silico Safety Assessment |
| title_full_unstemmed | Multi-Detector Characterization of Grape Seed Extract to Enable in silico Safety Assessment |
| title_short | Multi-Detector Characterization of Grape Seed Extract to Enable in silico Safety Assessment |
| title_sort | multi detector characterization of grape seed extract to enable in silico safety assessment |
| topic | Vitis vinifera grape seed dietary supplements oligomeric proanthocyanidins tannins threshold of toxicological concern |
| url | https://www.frontiersin.org/article/10.3389/fchem.2018.00334/full |
| work_keys_str_mv | AT vincentpsica multidetectorcharacterizationofgrapeseedextracttoenableinsilicosafetyassessment AT catherinemahony multidetectorcharacterizationofgrapeseedextracttoenableinsilicosafetyassessment AT timothyrbaker multidetectorcharacterizationofgrapeseedextracttoenableinsilicosafetyassessment |