Cell-Extrinsic Differentiation Block Mediated by EphA3 in Pre-Leukaemic Thymus Contributes to Disease Progression

Cell-Extrinsic Differentiation Block Mediated by EphA3 in Pre-Leukaemic Thymus Contributes to Disease Progression

We recently characterised the <i>NUP98-HOXD13</i> (<i>NHD13</i>) mouse as a model of T-cell pre-leukaemia, featuring thymocytes that can engraft in recipient animals and progress to T-cell acute lymphoblastic leukaemia (T-ALL). However, loss of this engraftment ability by del...

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Bibliographic Details
Main Authors: Adriana C. Pliego Zamora, Hansini Ranasinghe, Jessica E. Lisle, Chun Ki Ng, Stephen Huang, Racheal Wadlow, Andrew M. Scott, Andrew W. Boyd, Christopher I. Slape
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
T-ALL
Eph
pre-leukaemia
cell competition
Online Access:https://www.mdpi.com/2072-6694/13/15/3858

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