Vaccines and Therapeutics Against Hantaviruses
Hantaviruses (HVs) are rodent-transmitted viruses that can cause hantavirus cardiopulmonary syndrome (HCPS) in the Americas and hemorrhagic fever with renal syndrome (HFRS) in Eurasia. Together, these viruses have annually caused approximately 200,000 human infections worldwide in recent years, with...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-01-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2019.02989/full |
| _version_ | 1818022912223870976 |
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| author | Rongrong Liu Hongwei Ma Jiayi Shu Jiayi Shu Qiang Zhang Mingwei Han Ziyu Liu Xia Jin Fanglin Zhang Xingan Wu |
| author_facet | Rongrong Liu Hongwei Ma Jiayi Shu Jiayi Shu Qiang Zhang Mingwei Han Ziyu Liu Xia Jin Fanglin Zhang Xingan Wu |
| author_sort | Rongrong Liu |
| collection | DOAJ |
| description | Hantaviruses (HVs) are rodent-transmitted viruses that can cause hantavirus cardiopulmonary syndrome (HCPS) in the Americas and hemorrhagic fever with renal syndrome (HFRS) in Eurasia. Together, these viruses have annually caused approximately 200,000 human infections worldwide in recent years, with a case fatality rate of 5–15% for HFRS and up to 40% for HCPS. There is currently no effective treatment available for either HFRS or HCPS. Only whole virus inactivated vaccines against HTNV or SEOV are licensed for use in the Republic of Korea and China, but the protective efficacies of these vaccines are uncertain. To a large extent, the immune correlates of protection against hantavirus are not known. In this review, we summarized the epidemiology, virology, and pathogenesis of four HFRS-causing viruses, HTNV, SEOV, PUUV, and DOBV, and two HCPS-causing viruses, ANDV and SNV, and then discussed the existing knowledge on vaccines and therapeutics against these diseases. We think that this information will shed light on the rational development of new vaccines and treatments. |
| first_indexed | 2024-12-10T03:35:58Z |
| format | Article |
| id | doaj.art-51f2e5397a9447e9a14803d5c21f32f2 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-10T03:35:58Z |
| publishDate | 2020-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-51f2e5397a9447e9a14803d5c21f32f22022-12-22T02:03:42ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2020-01-011010.3389/fmicb.2019.02989502494Vaccines and Therapeutics Against HantavirusesRongrong Liu0Hongwei Ma1Jiayi Shu2Jiayi Shu3Qiang Zhang4Mingwei Han5Ziyu Liu6Xia Jin7Fanglin Zhang8Xingan Wu9Department of Microbiology, School of Basic Medicine, Fourth Military Medical University, Xi’an, ChinaDepartment of Microbiology, School of Basic Medicine, Fourth Military Medical University, Xi’an, ChinaScientific Research Center, Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education & Health, Shanghai Medical College, Fudan University, Shanghai, ChinaViral Disease and Vaccine Translational Research Unit, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, ChinaSchool of Biology and Basic Medical Sciences, Soochow University, Suzhou, ChinaCadet Brigade, School of Basic Medicine, Fourth Military Medical University, Xi’an, ChinaDepartment of Microbiology, School of Basic Medicine, Fourth Military Medical University, Xi’an, ChinaScientific Research Center, Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education & Health, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Microbiology, School of Basic Medicine, Fourth Military Medical University, Xi’an, ChinaDepartment of Microbiology, School of Basic Medicine, Fourth Military Medical University, Xi’an, ChinaHantaviruses (HVs) are rodent-transmitted viruses that can cause hantavirus cardiopulmonary syndrome (HCPS) in the Americas and hemorrhagic fever with renal syndrome (HFRS) in Eurasia. Together, these viruses have annually caused approximately 200,000 human infections worldwide in recent years, with a case fatality rate of 5–15% for HFRS and up to 40% for HCPS. There is currently no effective treatment available for either HFRS or HCPS. Only whole virus inactivated vaccines against HTNV or SEOV are licensed for use in the Republic of Korea and China, but the protective efficacies of these vaccines are uncertain. To a large extent, the immune correlates of protection against hantavirus are not known. In this review, we summarized the epidemiology, virology, and pathogenesis of four HFRS-causing viruses, HTNV, SEOV, PUUV, and DOBV, and two HCPS-causing viruses, ANDV and SNV, and then discussed the existing knowledge on vaccines and therapeutics against these diseases. We think that this information will shed light on the rational development of new vaccines and treatments.https://www.frontiersin.org/article/10.3389/fmicb.2019.02989/fullhantavirusvaccinetherapeutic strategiesHFRSHPCS |
| spellingShingle | Rongrong Liu Hongwei Ma Jiayi Shu Jiayi Shu Qiang Zhang Mingwei Han Ziyu Liu Xia Jin Fanglin Zhang Xingan Wu Vaccines and Therapeutics Against Hantaviruses Frontiers in Microbiology hantavirus vaccine therapeutic strategies HFRS HPCS |
| title | Vaccines and Therapeutics Against Hantaviruses |
| title_full | Vaccines and Therapeutics Against Hantaviruses |
| title_fullStr | Vaccines and Therapeutics Against Hantaviruses |
| title_full_unstemmed | Vaccines and Therapeutics Against Hantaviruses |
| title_short | Vaccines and Therapeutics Against Hantaviruses |
| title_sort | vaccines and therapeutics against hantaviruses |
| topic | hantavirus vaccine therapeutic strategies HFRS HPCS |
| url | https://www.frontiersin.org/article/10.3389/fmicb.2019.02989/full |
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