cAMP-Dependent Signaling and Ovarian Cancer
cAMP-dependent pathway is one of the most significant signaling cascades in healthy and neoplastic ovarian cells. Working through its major effector proteins—PKA and EPAC—it regulates gene expression and many cellular functions. PKA promotes the phosphorylation of cAMP response element-binding prote...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/23/3835 |
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| author | Agnieszka Kilanowska Agnieszka Ziółkowska Piotr Stasiak Magdalena Gibas-Dorna |
| author_facet | Agnieszka Kilanowska Agnieszka Ziółkowska Piotr Stasiak Magdalena Gibas-Dorna |
| author_sort | Agnieszka Kilanowska |
| collection | DOAJ |
| description | cAMP-dependent pathway is one of the most significant signaling cascades in healthy and neoplastic ovarian cells. Working through its major effector proteins—PKA and EPAC—it regulates gene expression and many cellular functions. PKA promotes the phosphorylation of cAMP response element-binding protein (CREB) which mediates gene transcription, cell migration, mitochondrial homeostasis, cell proliferation, and death. EPAC, on the other hand, is involved in cell adhesion, binding, differentiation, and interaction between cell junctions. Ovarian cancer growth and metabolism largely depend on changes in the signal processing of the cAMP-PKA-CREB axis, often associated with neoplastic transformation, metastasis, proliferation, and inhibition of apoptosis. In addition, the intracellular level of cAMP also determines the course of other pathways including AKT, ERK, MAPK, and mTOR, that are hypo- or hyperactivated among patients with ovarian neoplasm. With this review, we summarize the current findings on cAMP signaling in the ovary and its association with carcinogenesis, multiplication, metastasis, and survival of cancer cells. Additionally, we indicate that targeting particular stages of cAMP-dependent processes might provide promising therapeutic opportunities for the effective management of patients with ovarian cancer. |
| first_indexed | 2024-03-09T17:51:17Z |
| format | Article |
| id | doaj.art-51f37b38d82e4dd9a6a42ebb6c592b6e |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T17:51:17Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-51f37b38d82e4dd9a6a42ebb6c592b6e2023-11-24T10:44:35ZengMDPI AGCells2073-44092022-11-011123383510.3390/cells11233835cAMP-Dependent Signaling and Ovarian CancerAgnieszka Kilanowska0Agnieszka Ziółkowska1Piotr Stasiak2Magdalena Gibas-Dorna3Department of Anatomy and Histology, Collegium Medicum, University of Zielona Gora, 65-046 Zielona Gora, PolandDepartment of Anatomy and Histology, Collegium Medicum, University of Zielona Gora, 65-046 Zielona Gora, PolandDepartment of Anatomy and Histology, Collegium Medicum, University of Zielona Gora, 65-046 Zielona Gora, PolandDepartment of Anatomy and Histology, Collegium Medicum, University of Zielona Gora, 65-046 Zielona Gora, PolandcAMP-dependent pathway is one of the most significant signaling cascades in healthy and neoplastic ovarian cells. Working through its major effector proteins—PKA and EPAC—it regulates gene expression and many cellular functions. PKA promotes the phosphorylation of cAMP response element-binding protein (CREB) which mediates gene transcription, cell migration, mitochondrial homeostasis, cell proliferation, and death. EPAC, on the other hand, is involved in cell adhesion, binding, differentiation, and interaction between cell junctions. Ovarian cancer growth and metabolism largely depend on changes in the signal processing of the cAMP-PKA-CREB axis, often associated with neoplastic transformation, metastasis, proliferation, and inhibition of apoptosis. In addition, the intracellular level of cAMP also determines the course of other pathways including AKT, ERK, MAPK, and mTOR, that are hypo- or hyperactivated among patients with ovarian neoplasm. With this review, we summarize the current findings on cAMP signaling in the ovary and its association with carcinogenesis, multiplication, metastasis, and survival of cancer cells. Additionally, we indicate that targeting particular stages of cAMP-dependent processes might provide promising therapeutic opportunities for the effective management of patients with ovarian cancer.https://www.mdpi.com/2073-4409/11/23/3835ovarian cancercAMPPKACREBEPAC |
| spellingShingle | Agnieszka Kilanowska Agnieszka Ziółkowska Piotr Stasiak Magdalena Gibas-Dorna cAMP-Dependent Signaling and Ovarian Cancer Cells ovarian cancer cAMP PKA CREB EPAC |
| title | cAMP-Dependent Signaling and Ovarian Cancer |
| title_full | cAMP-Dependent Signaling and Ovarian Cancer |
| title_fullStr | cAMP-Dependent Signaling and Ovarian Cancer |
| title_full_unstemmed | cAMP-Dependent Signaling and Ovarian Cancer |
| title_short | cAMP-Dependent Signaling and Ovarian Cancer |
| title_sort | camp dependent signaling and ovarian cancer |
| topic | ovarian cancer cAMP PKA CREB EPAC |
| url | https://www.mdpi.com/2073-4409/11/23/3835 |
| work_keys_str_mv | AT agnieszkakilanowska campdependentsignalingandovariancancer AT agnieszkaziołkowska campdependentsignalingandovariancancer AT piotrstasiak campdependentsignalingandovariancancer AT magdalenagibasdorna campdependentsignalingandovariancancer |