Distribution and Elimination of Deltamethrin Toxicity in Laying Hens
Deltamethrin, an important pyrethroid insecticide, is frequently detected in human samples. This study aims to assess the potential effects of deltamethrin on human health and investigate the patterns of residue enrichment and elimination in 112 healthy laying hens. These hens were administered 20 m...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/12/24/4385 |
| _version_ | 1797381114521714688 |
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| author | Yiming Liu Chunshuang Liu Mingyue Han Na Yu Wen Pan Jie Wang Zhiying Fan Wei Wang Xiubo Li Xu Gu |
| author_facet | Yiming Liu Chunshuang Liu Mingyue Han Na Yu Wen Pan Jie Wang Zhiying Fan Wei Wang Xiubo Li Xu Gu |
| author_sort | Yiming Liu |
| collection | DOAJ |
| description | Deltamethrin, an important pyrethroid insecticide, is frequently detected in human samples. This study aims to assess the potential effects of deltamethrin on human health and investigate the patterns of residue enrichment and elimination in 112 healthy laying hens. These hens were administered 20 mg·kg<sup>−1</sup> deltamethrin based on their body weight. Gas chromatography-mass spectrometry (GC-MS) was used to investigate the residue enrichment pattern and elimination pattern of deltamethrin in the hens. The results indicated a significant increase in the concentration of deltamethrin in chicken manure during the treatment period. By the 14th day of administration, the concentration of deltamethrin in the stool reached 13,510.9 ± 172.24 μg·kg<sup>−1</sup>, with a fecal excretion rate of 67.56%. The pulmonary deltamethrin concentration was the second highest at 3844.98 ± 297.14 μg·kg<sup>−1</sup>. These findings suggest that chicken feces contain substantial amounts of deltamethrin after 14 days of continuous administration, and that it can easily transfer to the lungs. After 21 days of drug withdrawal, the residual concentration of deltamethrin in the fat of laying hens was 904.25 ± 295.32 μg·kg<sup>−1</sup>, with a half-life of 17 days and a slow elimination rate. In contrast, the lungs showed relatively low elimination half-lives of 0.2083 days, indicating faster elimination of deltamethrin in this tissue. These results highlight differences in the rate of deltamethrin elimination in different tissues during drug withdrawal. The fat of laying hens exhibited the highest residue of deltamethrin and the slowest elimination rate, while the lungs showed the fastest elimination rate. Moreover, deltamethrin was found to accumulate in the edible tissues of eggs and laying hens, suggesting that humans may be exposed to deltamethrin through food. |
| first_indexed | 2024-03-08T20:46:41Z |
| format | Article |
| id | doaj.art-51f3d3a7ddd44b57996b74d8a3a79b02 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-08T20:46:41Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-51f3d3a7ddd44b57996b74d8a3a79b022023-12-22T14:08:29ZengMDPI AGFoods2304-81582023-12-011224438510.3390/foods12244385Distribution and Elimination of Deltamethrin Toxicity in Laying HensYiming Liu0Chunshuang Liu1Mingyue Han2Na Yu3Wen Pan4Jie Wang5Zhiying Fan6Wei Wang7Xiubo Li8Xu Gu9National Feed Drug Reference Laboratories, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinaNational Feed Drug Reference Laboratories, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinaNational Feed Drug Reference Laboratories, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinaNational Feed Drug Reference Laboratories, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinaZhong Mu Institutes of China Animal Husbandry Industry Co., Ltd., Beijing 100095, ChinaLaboratory of Quality & Safety Risk Assessment for Products on Feed-Origin Risk Factor, Ministry of Agriculture and Rural Affairs, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinaLaboratory of Quality & Safety Risk Assessment for Products on Feed-Origin Risk Factor, Ministry of Agriculture and Rural Affairs, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinaLaboratory of Quality & Safety Risk Assessment for Products on Feed-Origin Risk Factor, Ministry of Agriculture and Rural Affairs, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinaNational Feed Drug Reference Laboratories, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinaLaboratory of Quality & Safety Risk Assessment for Products on Feed-Origin Risk Factor, Ministry of Agriculture and Rural Affairs, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinaDeltamethrin, an important pyrethroid insecticide, is frequently detected in human samples. This study aims to assess the potential effects of deltamethrin on human health and investigate the patterns of residue enrichment and elimination in 112 healthy laying hens. These hens were administered 20 mg·kg<sup>−1</sup> deltamethrin based on their body weight. Gas chromatography-mass spectrometry (GC-MS) was used to investigate the residue enrichment pattern and elimination pattern of deltamethrin in the hens. The results indicated a significant increase in the concentration of deltamethrin in chicken manure during the treatment period. By the 14th day of administration, the concentration of deltamethrin in the stool reached 13,510.9 ± 172.24 μg·kg<sup>−1</sup>, with a fecal excretion rate of 67.56%. The pulmonary deltamethrin concentration was the second highest at 3844.98 ± 297.14 μg·kg<sup>−1</sup>. These findings suggest that chicken feces contain substantial amounts of deltamethrin after 14 days of continuous administration, and that it can easily transfer to the lungs. After 21 days of drug withdrawal, the residual concentration of deltamethrin in the fat of laying hens was 904.25 ± 295.32 μg·kg<sup>−1</sup>, with a half-life of 17 days and a slow elimination rate. In contrast, the lungs showed relatively low elimination half-lives of 0.2083 days, indicating faster elimination of deltamethrin in this tissue. These results highlight differences in the rate of deltamethrin elimination in different tissues during drug withdrawal. The fat of laying hens exhibited the highest residue of deltamethrin and the slowest elimination rate, while the lungs showed the fastest elimination rate. Moreover, deltamethrin was found to accumulate in the edible tissues of eggs and laying hens, suggesting that humans may be exposed to deltamethrin through food.https://www.mdpi.com/2304-8158/12/24/4385deltamethrinGC-MSlaying hensresidue enrichmentresidue elimination |
| spellingShingle | Yiming Liu Chunshuang Liu Mingyue Han Na Yu Wen Pan Jie Wang Zhiying Fan Wei Wang Xiubo Li Xu Gu Distribution and Elimination of Deltamethrin Toxicity in Laying Hens Foods deltamethrin GC-MS laying hens residue enrichment residue elimination |
| title | Distribution and Elimination of Deltamethrin Toxicity in Laying Hens |
| title_full | Distribution and Elimination of Deltamethrin Toxicity in Laying Hens |
| title_fullStr | Distribution and Elimination of Deltamethrin Toxicity in Laying Hens |
| title_full_unstemmed | Distribution and Elimination of Deltamethrin Toxicity in Laying Hens |
| title_short | Distribution and Elimination of Deltamethrin Toxicity in Laying Hens |
| title_sort | distribution and elimination of deltamethrin toxicity in laying hens |
| topic | deltamethrin GC-MS laying hens residue enrichment residue elimination |
| url | https://www.mdpi.com/2304-8158/12/24/4385 |
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