Identification of Novel Mutations in CDC20: Expanding the Mutational Spectrum for Female Infertility

Identification of Novel Mutations in CDC20: Expanding the Mutational Spectrum for Female Infertility

Oocyte maturation and fertilization are fundamental processes for successful human reproduction, and abnormalities in these processes will cause infertility. Recently, we identified biallelic mutations in CDC20 that are responsible for human oocyte maturation arrest, fertilization failure, and early...

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Bibliographic Details
Main Authors: Lin Zhao, Yichun Guan, Qingxia Meng, Weijie Wang, Ling Wu, Biaobang Chen, Jijun Hu, Jiawei Zhu, Zhihua Zhang, Jian Mu, Yao Chen, Yiming Sun, Tianyu Wu, Wenjing Wang, Zhou Zhou, Jie Dong, Yang Zeng, Ruyi Liu, Qiaoli Li, Jing Du, Yanping Kuang, Qing Sang, Lei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
female infertility
CDC20
novel mutation
oocyte maturation arrest
fertilization failure
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.647130/full

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