Management of malignant pleural effusion: challenges and solutions
Erika Penz,1 Kristina N Watt,1 Christopher A Hergott,2 Najib M Rahman,3 Ioannis Psallidas3 1Division of Respirology, Department of Medicine, University of Saskatchewan, Saskatoon, SK, 2Division of Respirology, Department of Medicine, University of Calgary, Calgary, AB, Canada; 3Oxford Centre&nbs...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-06-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/management-of-malignant-pleural-effusion-challenges-and-solutions-peer-reviewed-article-CMAR |
| _version_ | 1819243049473015808 |
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| author | Penz E Watt KN Hergott CA Rahman NM Psallidas I |
| author_facet | Penz E Watt KN Hergott CA Rahman NM Psallidas I |
| author_sort | Penz E |
| collection | DOAJ |
| description | Erika Penz,1 Kristina N Watt,1 Christopher A Hergott,2 Najib M Rahman,3 Ioannis Psallidas3 1Division of Respirology, Department of Medicine, University of Saskatchewan, Saskatoon, SK, 2Division of Respirology, Department of Medicine, University of Calgary, Calgary, AB, Canada; 3Oxford Centre for Respiratory Medicine, Respiratory Trials Unit, Oxford University, Oxford, UK Abstract: Malignant pleural effusion (MPE) is a sign of advanced cancer and is associated with significant symptom burden and mortality. To date, management has been palliative in nature with a focus on draining the pleural space, with therapies aimed at preventing recurrence or providing intermittent drainage through indwelling catheters. Given that patients with MPEs are heterogeneous with respect to their cancer type and response to systemic therapy, functional status, and pleural milieu, response to MPE therapy is also heterogeneous and difficult to predict. Furthermore, the impact of therapies on important patient outcomes has only recently been evaluated consistently in clinical trials and cohort studies. In this review, we examine patient outcomes that have been studied to date, address the question of which are most important for managing patients, and review the literature related to the expected value for money (cost-effectiveness) of indwelling pleural catheters relative to traditionally recommended approaches. Keywords: malignant pleural effusion, therapeutics, cost-effectiveness, quality of life |
| first_indexed | 2024-12-23T14:49:31Z |
| format | Article |
| id | doaj.art-51f76a59986d48b184c2ae413dc7a4eb |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-23T14:49:31Z |
| publishDate | 2017-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-51f76a59986d48b184c2ae413dc7a4eb2022-12-21T17:43:00ZengDove Medical PressCancer Management and Research1179-13222017-06-01Volume 922924133422Management of malignant pleural effusion: challenges and solutionsPenz EWatt KNHergott CARahman NMPsallidas IErika Penz,1 Kristina N Watt,1 Christopher A Hergott,2 Najib M Rahman,3 Ioannis Psallidas3 1Division of Respirology, Department of Medicine, University of Saskatchewan, Saskatoon, SK, 2Division of Respirology, Department of Medicine, University of Calgary, Calgary, AB, Canada; 3Oxford Centre for Respiratory Medicine, Respiratory Trials Unit, Oxford University, Oxford, UK Abstract: Malignant pleural effusion (MPE) is a sign of advanced cancer and is associated with significant symptom burden and mortality. To date, management has been palliative in nature with a focus on draining the pleural space, with therapies aimed at preventing recurrence or providing intermittent drainage through indwelling catheters. Given that patients with MPEs are heterogeneous with respect to their cancer type and response to systemic therapy, functional status, and pleural milieu, response to MPE therapy is also heterogeneous and difficult to predict. Furthermore, the impact of therapies on important patient outcomes has only recently been evaluated consistently in clinical trials and cohort studies. In this review, we examine patient outcomes that have been studied to date, address the question of which are most important for managing patients, and review the literature related to the expected value for money (cost-effectiveness) of indwelling pleural catheters relative to traditionally recommended approaches. Keywords: malignant pleural effusion, therapeutics, cost-effectiveness, quality of life https://www.dovepress.com/management-of-malignant-pleural-effusion-challenges-and-solutions-peer-reviewed-article-CMARMalignant Pleural EffusionTherapeuticsCost-effectivenessQuality of life |
| spellingShingle | Penz E Watt KN Hergott CA Rahman NM Psallidas I Management of malignant pleural effusion: challenges and solutions Cancer Management and Research Malignant Pleural Effusion Therapeutics Cost-effectiveness Quality of life |
| title | Management of malignant pleural effusion: challenges and solutions |
| title_full | Management of malignant pleural effusion: challenges and solutions |
| title_fullStr | Management of malignant pleural effusion: challenges and solutions |
| title_full_unstemmed | Management of malignant pleural effusion: challenges and solutions |
| title_short | Management of malignant pleural effusion: challenges and solutions |
| title_sort | management of malignant pleural effusion challenges and solutions |
| topic | Malignant Pleural Effusion Therapeutics Cost-effectiveness Quality of life |
| url | https://www.dovepress.com/management-of-malignant-pleural-effusion-challenges-and-solutions-peer-reviewed-article-CMAR |
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