Collider bias and the apparent protective effect of glucose-6-phosphate dehydrogenase deficiency on cerebral malaria

Collider bias and the apparent protective effect of glucose-6-phosphate dehydrogenase deficiency on cerebral malaria

Case fatality rates in severe falciparum malaria depend on the pattern and degree of vital organ dysfunction. Recent large-scale case-control analyses of pooled severe malaria data reported that glucose-6-phosphate dehydrogenase deficiency (G6PDd) was protective against cerebral malaria but increase...

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Bibliographic Details
Main Authors: James A Watson, Stije J Leopold, Julie A Simpson, Nicholas PJ Day, Arjen M Dondorp, Nicholas J White
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-01-01
Series:eLife
Subjects:
causal inference
severe malaria
collider bias
glucose-6-phosphate dehydrogenase deficiency
Plasmodium falciparum
Online Access:https://elifesciences.org/articles/43154

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