Chemotherapy Resistance: Role of Mitochondrial and Autophagic Components
Cancer chemotherapy resistance is one of the most critical obstacles in cancer therapy. One of the well-known mechanisms of chemotherapy resistance is the change in the mitochondrial death pathways which occur when cells are under stressful situations, such as chemotherapy. Mitophagy, or mitochondri...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/6/1462 |
| _version_ | 1797446888022081536 |
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| author | Entaz Bahar Sun-Young Han Ji-Ye Kim Hyonok Yoon |
| author_facet | Entaz Bahar Sun-Young Han Ji-Ye Kim Hyonok Yoon |
| author_sort | Entaz Bahar |
| collection | DOAJ |
| description | Cancer chemotherapy resistance is one of the most critical obstacles in cancer therapy. One of the well-known mechanisms of chemotherapy resistance is the change in the mitochondrial death pathways which occur when cells are under stressful situations, such as chemotherapy. Mitophagy, or mitochondrial selective autophagy, is critical for cell quality control because it can efficiently break down, remove, and recycle defective or damaged mitochondria. As cancer cells use mitophagy to rapidly sweep away damaged mitochondria in order to mediate their own drug resistance, it influences the efficacy of tumor chemotherapy as well as the degree of drug resistance. Yet despite the importance of mitochondria and mitophagy in chemotherapy resistance, little is known about the precise mechanisms involved. As a consequence, identifying potential therapeutic targets by analyzing the signal pathways that govern mitophagy has become a vital research goal. In this paper, we review recent advances in mitochondrial research, mitophagy control mechanisms, and their implications for our understanding of chemotherapy resistance. |
| first_indexed | 2024-03-09T13:48:04Z |
| format | Article |
| id | doaj.art-51f93724894b4865845ab2a97c74e957 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T13:48:04Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-51f93724894b4865845ab2a97c74e9572023-11-30T20:55:52ZengMDPI AGCancers2072-66942022-03-01146146210.3390/cancers14061462Chemotherapy Resistance: Role of Mitochondrial and Autophagic ComponentsEntaz Bahar0Sun-Young Han1Ji-Ye Kim2Hyonok Yoon3College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju 52828, KoreaCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju 52828, KoreaDepartment of Pathology, Ilsan Paik Hospital, College of Medicine, Inje University, Goyang 10380, KoreaCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju 52828, KoreaCancer chemotherapy resistance is one of the most critical obstacles in cancer therapy. One of the well-known mechanisms of chemotherapy resistance is the change in the mitochondrial death pathways which occur when cells are under stressful situations, such as chemotherapy. Mitophagy, or mitochondrial selective autophagy, is critical for cell quality control because it can efficiently break down, remove, and recycle defective or damaged mitochondria. As cancer cells use mitophagy to rapidly sweep away damaged mitochondria in order to mediate their own drug resistance, it influences the efficacy of tumor chemotherapy as well as the degree of drug resistance. Yet despite the importance of mitochondria and mitophagy in chemotherapy resistance, little is known about the precise mechanisms involved. As a consequence, identifying potential therapeutic targets by analyzing the signal pathways that govern mitophagy has become a vital research goal. In this paper, we review recent advances in mitochondrial research, mitophagy control mechanisms, and their implications for our understanding of chemotherapy resistance.https://www.mdpi.com/2072-6694/14/6/1462chemotherapy resistancemitochondriamitophagy |
| spellingShingle | Entaz Bahar Sun-Young Han Ji-Ye Kim Hyonok Yoon Chemotherapy Resistance: Role of Mitochondrial and Autophagic Components Cancers chemotherapy resistance mitochondria mitophagy |
| title | Chemotherapy Resistance: Role of Mitochondrial and Autophagic Components |
| title_full | Chemotherapy Resistance: Role of Mitochondrial and Autophagic Components |
| title_fullStr | Chemotherapy Resistance: Role of Mitochondrial and Autophagic Components |
| title_full_unstemmed | Chemotherapy Resistance: Role of Mitochondrial and Autophagic Components |
| title_short | Chemotherapy Resistance: Role of Mitochondrial and Autophagic Components |
| title_sort | chemotherapy resistance role of mitochondrial and autophagic components |
| topic | chemotherapy resistance mitochondria mitophagy |
| url | https://www.mdpi.com/2072-6694/14/6/1462 |
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