Adipose Tissue-Derived Components: From Cells to Tissue Glue to Treat Dermal Damage
In recent decades, adipose tissue transplantation has become an essential treatment modality for tissue (volume) restoration and regeneration. The regenerative application of adipose tissue has only recently proven its usefulness; for example, the method is useful in reducing dermal scarring and acc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/10/3/328 |
| _version_ | 1797613407926484992 |
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| author | Linda Vriend Berend van der Lei Martin C. Harmsen Joris A. van Dongen |
| author_facet | Linda Vriend Berend van der Lei Martin C. Harmsen Joris A. van Dongen |
| author_sort | Linda Vriend |
| collection | DOAJ |
| description | In recent decades, adipose tissue transplantation has become an essential treatment modality for tissue (volume) restoration and regeneration. The regenerative application of adipose tissue has only recently proven its usefulness; for example, the method is useful in reducing dermal scarring and accelerating skin-wound healing. The therapeutic effect is ascribed to the tissue stromal vascular fraction (tSVF) in adipose tissue. This consists of stromal cells, the trophic factors they secrete and the extracellular matrix (ECM), which have immune-modulating, pro-angiogenic and anti-fibrotic properties. This concise review focused on dermal regeneration using the following adipose-tissue components: adipose-tissue-derived stromal cells (ASCs), their secreted trophic factors (ASCs secretome), and the ECM. The opportunities of using a therapeutically functional scaffold, composed of a decellularized ECM hydrogel loaded with trophic factors of ASCs, to enhance wound healing are explored as well. An ECM-based hydrogel loaded with trophic factors combines all regenerative components of adipose tissue, while averting the possible disadvantages of the therapeutic use of adipose tissue, e.g., the necessity of liposuction procedures with a (small) risk of complications, the impossibility of interpatient use, and the limited storage options. |
| first_indexed | 2024-03-11T06:55:23Z |
| format | Article |
| id | doaj.art-51fab7073d3d4b6eabaaf48857e5926c |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-11T06:55:23Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-51fab7073d3d4b6eabaaf48857e5926c2023-11-17T09:39:44ZengMDPI AGBioengineering2306-53542023-03-0110332810.3390/bioengineering10030328Adipose Tissue-Derived Components: From Cells to Tissue Glue to Treat Dermal DamageLinda Vriend0Berend van der Lei1Martin C. Harmsen2Joris A. van Dongen3Department of Plastic Surgery, University of Utrecht, University Medical Center Utrecht, 3584 CS Utrecht, The NetherlandsDepartment of Plastic Surgery, University of Groningen, University Medical Center Groningen, 9700 AC Groningen, The NetherlandsDepartment of Pathology & Medical Biology, University of Groningen, University Medical Center Groningen, 9700 AC Groningen, The NetherlandsDepartment of Plastic Surgery, University of Utrecht, University Medical Center Utrecht, 3584 CS Utrecht, The NetherlandsIn recent decades, adipose tissue transplantation has become an essential treatment modality for tissue (volume) restoration and regeneration. The regenerative application of adipose tissue has only recently proven its usefulness; for example, the method is useful in reducing dermal scarring and accelerating skin-wound healing. The therapeutic effect is ascribed to the tissue stromal vascular fraction (tSVF) in adipose tissue. This consists of stromal cells, the trophic factors they secrete and the extracellular matrix (ECM), which have immune-modulating, pro-angiogenic and anti-fibrotic properties. This concise review focused on dermal regeneration using the following adipose-tissue components: adipose-tissue-derived stromal cells (ASCs), their secreted trophic factors (ASCs secretome), and the ECM. The opportunities of using a therapeutically functional scaffold, composed of a decellularized ECM hydrogel loaded with trophic factors of ASCs, to enhance wound healing are explored as well. An ECM-based hydrogel loaded with trophic factors combines all regenerative components of adipose tissue, while averting the possible disadvantages of the therapeutic use of adipose tissue, e.g., the necessity of liposuction procedures with a (small) risk of complications, the impossibility of interpatient use, and the limited storage options.https://www.mdpi.com/2306-5354/10/3/328dermal damageASCsASC secretomeSVFECMExtracellular matrix |
| spellingShingle | Linda Vriend Berend van der Lei Martin C. Harmsen Joris A. van Dongen Adipose Tissue-Derived Components: From Cells to Tissue Glue to Treat Dermal Damage Bioengineering dermal damage ASCs ASC secretome SVF ECM Extracellular matrix |
| title | Adipose Tissue-Derived Components: From Cells to Tissue Glue to Treat Dermal Damage |
| title_full | Adipose Tissue-Derived Components: From Cells to Tissue Glue to Treat Dermal Damage |
| title_fullStr | Adipose Tissue-Derived Components: From Cells to Tissue Glue to Treat Dermal Damage |
| title_full_unstemmed | Adipose Tissue-Derived Components: From Cells to Tissue Glue to Treat Dermal Damage |
| title_short | Adipose Tissue-Derived Components: From Cells to Tissue Glue to Treat Dermal Damage |
| title_sort | adipose tissue derived components from cells to tissue glue to treat dermal damage |
| topic | dermal damage ASCs ASC secretome SVF ECM Extracellular matrix |
| url | https://www.mdpi.com/2306-5354/10/3/328 |
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