Amelioration of Hepatotoxic and Neurotoxic Effect of Cartap by <i>Aloe vera</i> in Wistar Rats
Pesticide exposure can pose a serious risk to nontarget animals. Cartap is being broadly used in agricultural fields. The toxic effects of cartap on the levels of hepatotoxicity and neurotoxicity have not been properly studied in mammalian systems. Therefore, the present work focused on the effect o...
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MDPI AG
2023-05-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/11/5/472 |
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| author | Vivek Kumar Gupta Uichang Park Nikhat J. Siddiqi Yun Suk Huh Bechan Sharma |
| author_facet | Vivek Kumar Gupta Uichang Park Nikhat J. Siddiqi Yun Suk Huh Bechan Sharma |
| author_sort | Vivek Kumar Gupta |
| collection | DOAJ |
| description | Pesticide exposure can pose a serious risk to nontarget animals. Cartap is being broadly used in agricultural fields. The toxic effects of cartap on the levels of hepatotoxicity and neurotoxicity have not been properly studied in mammalian systems. Therefore, the present work focused on the effect of cartap on the liver and brain of Wistar rats and made an assessment of the ameliorating potential of <i>A. vera</i>. The experimental animals were divided into 4 groups, comprising six rats in each: Group 1—Control; Group 2—<i>A. vera</i>; Group 3—Cartap; and Group 4—<i>A. vera</i> + Cartap. The animals orally given cartap and <i>A. vera</i> were sacrificed after 24 h of the final treatment and histological and biochemical investigations were conducted in liver and brain of Wistar rats. Cartap at sublethal concentrations caused substantial decreases in CAT, SOD, and GST levels in the experimental rats. The activity levels of transaminases and phosphatases in cartap group were also found to be substantially altered. The AChE activity was recorded as decreasing in RBC membrane and brain of the cartap-treated animals. The TNF-α and IL-6 level in serum were increased expressively in the cartap challenged groups. Histological investigation of liver showed disorganized hepatic cords and severely congested central veins due to cartap. However, the <i>A. vera</i> extract was observed to significantly protect against the effects of cartap toxicity. The protective impact of <i>A. vera</i> against cartap toxicity may be due to the existence of antioxidants in it. These findings suggest that <i>A. vera</i> may be developed as a potential supplement to the appropriate medication in the treatment of cartap toxicity. |
| first_indexed | 2024-03-11T03:15:20Z |
| format | Article |
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| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-11T03:15:20Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-51fe8cd2f317458595f6d63f45fb04352023-11-18T03:33:07ZengMDPI AGToxics2305-63042023-05-0111547210.3390/toxics11050472Amelioration of Hepatotoxic and Neurotoxic Effect of Cartap by <i>Aloe vera</i> in Wistar RatsVivek Kumar Gupta0Uichang Park1Nikhat J. Siddiqi2Yun Suk Huh3Bechan Sharma4Department of Biochemistry, University of Allahabad, Prayagraj 211002, IndiaNanoBio High-Tech Materials Research Center, Department of Biological Sciences and Bioengineering, Inha University, Incheon 22212, Republic of KoreaFCSM-Department of Biochemistry, King Saud University, Riyadh 11495, Saudi ArabiaNanoBio High-Tech Materials Research Center, Department of Biological Sciences and Bioengineering, Inha University, Incheon 22212, Republic of KoreaDepartment of Biochemistry, University of Allahabad, Prayagraj 211002, IndiaPesticide exposure can pose a serious risk to nontarget animals. Cartap is being broadly used in agricultural fields. The toxic effects of cartap on the levels of hepatotoxicity and neurotoxicity have not been properly studied in mammalian systems. Therefore, the present work focused on the effect of cartap on the liver and brain of Wistar rats and made an assessment of the ameliorating potential of <i>A. vera</i>. The experimental animals were divided into 4 groups, comprising six rats in each: Group 1—Control; Group 2—<i>A. vera</i>; Group 3—Cartap; and Group 4—<i>A. vera</i> + Cartap. The animals orally given cartap and <i>A. vera</i> were sacrificed after 24 h of the final treatment and histological and biochemical investigations were conducted in liver and brain of Wistar rats. Cartap at sublethal concentrations caused substantial decreases in CAT, SOD, and GST levels in the experimental rats. The activity levels of transaminases and phosphatases in cartap group were also found to be substantially altered. The AChE activity was recorded as decreasing in RBC membrane and brain of the cartap-treated animals. The TNF-α and IL-6 level in serum were increased expressively in the cartap challenged groups. Histological investigation of liver showed disorganized hepatic cords and severely congested central veins due to cartap. However, the <i>A. vera</i> extract was observed to significantly protect against the effects of cartap toxicity. The protective impact of <i>A. vera</i> against cartap toxicity may be due to the existence of antioxidants in it. These findings suggest that <i>A. vera</i> may be developed as a potential supplement to the appropriate medication in the treatment of cartap toxicity.https://www.mdpi.com/2305-6304/11/5/472cartaphepatotoxicityneurotoxicityantioxidantshistopathology<i>Aloe vera</i> |
| spellingShingle | Vivek Kumar Gupta Uichang Park Nikhat J. Siddiqi Yun Suk Huh Bechan Sharma Amelioration of Hepatotoxic and Neurotoxic Effect of Cartap by <i>Aloe vera</i> in Wistar Rats Toxics cartap hepatotoxicity neurotoxicity antioxidants histopathology <i>Aloe vera</i> |
| title | Amelioration of Hepatotoxic and Neurotoxic Effect of Cartap by <i>Aloe vera</i> in Wistar Rats |
| title_full | Amelioration of Hepatotoxic and Neurotoxic Effect of Cartap by <i>Aloe vera</i> in Wistar Rats |
| title_fullStr | Amelioration of Hepatotoxic and Neurotoxic Effect of Cartap by <i>Aloe vera</i> in Wistar Rats |
| title_full_unstemmed | Amelioration of Hepatotoxic and Neurotoxic Effect of Cartap by <i>Aloe vera</i> in Wistar Rats |
| title_short | Amelioration of Hepatotoxic and Neurotoxic Effect of Cartap by <i>Aloe vera</i> in Wistar Rats |
| title_sort | amelioration of hepatotoxic and neurotoxic effect of cartap by i aloe vera i in wistar rats |
| topic | cartap hepatotoxicity neurotoxicity antioxidants histopathology <i>Aloe vera</i> |
| url | https://www.mdpi.com/2305-6304/11/5/472 |
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