Effect of Hyperprolactinemia on Bone Metabolism: Focusing on Osteopenia/Osteoporosis
Prolactin is a hormone secreted from lactotroph cells in the anterior pituitary gland to induce lactation after birth. Hyperprolactinemia unrelated to lactation is a common cause of amenorrhea in women of a childbearing age, and a consequent decrease in the gonadotropin-releasing hormone (GnRH) by a...
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MDPI AG
2024-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/3/1474 |
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| author | Soo Jin Yun Hyunji Sang So Young Park Sang Ouk Chin |
| author_facet | Soo Jin Yun Hyunji Sang So Young Park Sang Ouk Chin |
| author_sort | Soo Jin Yun |
| collection | DOAJ |
| description | Prolactin is a hormone secreted from lactotroph cells in the anterior pituitary gland to induce lactation after birth. Hyperprolactinemia unrelated to lactation is a common cause of amenorrhea in women of a childbearing age, and a consequent decrease in the gonadotropin-releasing hormone (GnRH) by a high prolactin level can result in decreased bone mineral density. Osteoporosis is a common skeletal disorder characterized by decreased bone mineral density (BMD) and quality, which results in decreased bone strength. In patients with hyperprolactinemia, changes in BMD can be induced indirectly by the inhibition of the GnRH–gonadal axis due to increased prolactin levels or by the direct action of prolactin on osteoblasts and, possibly, osteoclast cells. This review highlights the recent work on bone remodeling and discusses our knowledge of how prolactin modulates these interactions, with a brief literature review on the relationship between prolactin and bone metabolism and suggestions for new possibilities. |
| first_indexed | 2024-03-08T03:55:31Z |
| format | Article |
| id | doaj.art-520049eb0e6e4c2fb29326183909d5cc |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T03:55:31Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-520049eb0e6e4c2fb29326183909d5cc2024-02-09T15:13:23ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-01-01253147410.3390/ijms25031474Effect of Hyperprolactinemia on Bone Metabolism: Focusing on Osteopenia/OsteoporosisSoo Jin Yun0Hyunji Sang1So Young Park2Sang Ouk Chin3Department of Endocrinology and Metabolism, Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul 02447, Republic of KoreaDepartment of Endocrinology and Metabolism, Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul 02447, Republic of KoreaDepartment of Endocrinology and Metabolism, Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul 02447, Republic of KoreaDepartment of Endocrinology and Metabolism, Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul 02447, Republic of KoreaProlactin is a hormone secreted from lactotroph cells in the anterior pituitary gland to induce lactation after birth. Hyperprolactinemia unrelated to lactation is a common cause of amenorrhea in women of a childbearing age, and a consequent decrease in the gonadotropin-releasing hormone (GnRH) by a high prolactin level can result in decreased bone mineral density. Osteoporosis is a common skeletal disorder characterized by decreased bone mineral density (BMD) and quality, which results in decreased bone strength. In patients with hyperprolactinemia, changes in BMD can be induced indirectly by the inhibition of the GnRH–gonadal axis due to increased prolactin levels or by the direct action of prolactin on osteoblasts and, possibly, osteoclast cells. This review highlights the recent work on bone remodeling and discusses our knowledge of how prolactin modulates these interactions, with a brief literature review on the relationship between prolactin and bone metabolism and suggestions for new possibilities.https://www.mdpi.com/1422-0067/25/3/1474hyperprolactinemiabone metabolismosteoporosisosteopenia |
| spellingShingle | Soo Jin Yun Hyunji Sang So Young Park Sang Ouk Chin Effect of Hyperprolactinemia on Bone Metabolism: Focusing on Osteopenia/Osteoporosis International Journal of Molecular Sciences hyperprolactinemia bone metabolism osteoporosis osteopenia |
| title | Effect of Hyperprolactinemia on Bone Metabolism: Focusing on Osteopenia/Osteoporosis |
| title_full | Effect of Hyperprolactinemia on Bone Metabolism: Focusing on Osteopenia/Osteoporosis |
| title_fullStr | Effect of Hyperprolactinemia on Bone Metabolism: Focusing on Osteopenia/Osteoporosis |
| title_full_unstemmed | Effect of Hyperprolactinemia on Bone Metabolism: Focusing on Osteopenia/Osteoporosis |
| title_short | Effect of Hyperprolactinemia on Bone Metabolism: Focusing on Osteopenia/Osteoporosis |
| title_sort | effect of hyperprolactinemia on bone metabolism focusing on osteopenia osteoporosis |
| topic | hyperprolactinemia bone metabolism osteoporosis osteopenia |
| url | https://www.mdpi.com/1422-0067/25/3/1474 |
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