Pregnancy and Multiple Sclerosis: An Update on the Disease Modifying Treatment Strategy and a Review of Pregnancy’s Impact on Disease Activity
Pregnancy rates are rapidly increasing among women of reproductive age diagnosed with multiple sclerosis (MS). Through pre-conception, pregnancy and post-partum periods, there is a need for disease control management, to decrease chances of MS relapses while avoiding potential risks to the mother an...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-01-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1010-660X/56/2/49 |
| _version_ | 1797727552231440384 |
|---|---|
| author | Guoda Varytė Jolita Zakarevičienė Diana Ramašauskaitė Dalia Laužikienė Audronė Arlauskienė |
| author_facet | Guoda Varytė Jolita Zakarevičienė Diana Ramašauskaitė Dalia Laužikienė Audronė Arlauskienė |
| author_sort | Guoda Varytė |
| collection | DOAJ |
| description | Pregnancy rates are rapidly increasing among women of reproductive age diagnosed with multiple sclerosis (MS). Through pre-conception, pregnancy and post-partum periods, there is a need for disease control management, to decrease chances of MS relapses while avoiding potential risks to the mother and the fetus. However, pregnancy is not always compatible with the available highly effective MS treatments. This narrative review provides the aspects of pregnancy’s outcomes and the impact on disease activity, choices of anesthesia and the management of relapses during the pregnancy and breastfeeding period. Available disease modifying treatment is discussed in the article with new data supporting the strategy of continuing natalizumab after conception, as it is related to a decreased risk of MS relapses during the pregnancy and postpartum period. |
| first_indexed | 2024-03-12T11:01:24Z |
| format | Article |
| id | doaj.art-5201670871e84a589abe385462f65946 |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T11:01:24Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-5201670871e84a589abe385462f659462023-09-02T05:38:03ZengMDPI AGMedicina1010-660X2020-01-015624910.3390/medicina56020049medicina56020049Pregnancy and Multiple Sclerosis: An Update on the Disease Modifying Treatment Strategy and a Review of Pregnancy’s Impact on Disease ActivityGuoda Varytė0Jolita Zakarevičienė1Diana Ramašauskaitė2Dalia Laužikienė3Audronė Arlauskienė4Faculty of Medicine, Vilnius University, 03101 Vilnius, LithuaniaClinic of Obstetrics and Gynaecology, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, 03101 Vilnius, LithuaniaClinic of Obstetrics and Gynaecology, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, 03101 Vilnius, LithuaniaClinic of Obstetrics and Gynaecology, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, 03101 Vilnius, LithuaniaClinic of Obstetrics and Gynaecology, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, 03101 Vilnius, LithuaniaPregnancy rates are rapidly increasing among women of reproductive age diagnosed with multiple sclerosis (MS). Through pre-conception, pregnancy and post-partum periods, there is a need for disease control management, to decrease chances of MS relapses while avoiding potential risks to the mother and the fetus. However, pregnancy is not always compatible with the available highly effective MS treatments. This narrative review provides the aspects of pregnancy’s outcomes and the impact on disease activity, choices of anesthesia and the management of relapses during the pregnancy and breastfeeding period. Available disease modifying treatment is discussed in the article with new data supporting the strategy of continuing natalizumab after conception, as it is related to a decreased risk of MS relapses during the pregnancy and postpartum period.https://www.mdpi.com/1010-660X/56/2/49pregnancymultiple sclerosisrelapsesbreastfeedingdisease modifying therapy |
| spellingShingle | Guoda Varytė Jolita Zakarevičienė Diana Ramašauskaitė Dalia Laužikienė Audronė Arlauskienė Pregnancy and Multiple Sclerosis: An Update on the Disease Modifying Treatment Strategy and a Review of Pregnancy’s Impact on Disease Activity Medicina pregnancy multiple sclerosis relapses breastfeeding disease modifying therapy |
| title | Pregnancy and Multiple Sclerosis: An Update on the Disease Modifying Treatment Strategy and a Review of Pregnancy’s Impact on Disease Activity |
| title_full | Pregnancy and Multiple Sclerosis: An Update on the Disease Modifying Treatment Strategy and a Review of Pregnancy’s Impact on Disease Activity |
| title_fullStr | Pregnancy and Multiple Sclerosis: An Update on the Disease Modifying Treatment Strategy and a Review of Pregnancy’s Impact on Disease Activity |
| title_full_unstemmed | Pregnancy and Multiple Sclerosis: An Update on the Disease Modifying Treatment Strategy and a Review of Pregnancy’s Impact on Disease Activity |
| title_short | Pregnancy and Multiple Sclerosis: An Update on the Disease Modifying Treatment Strategy and a Review of Pregnancy’s Impact on Disease Activity |
| title_sort | pregnancy and multiple sclerosis an update on the disease modifying treatment strategy and a review of pregnancy s impact on disease activity |
| topic | pregnancy multiple sclerosis relapses breastfeeding disease modifying therapy |
| url | https://www.mdpi.com/1010-660X/56/2/49 |
| work_keys_str_mv | AT guodavaryte pregnancyandmultiplesclerosisanupdateonthediseasemodifyingtreatmentstrategyandareviewofpregnancysimpactondiseaseactivity AT jolitazakareviciene pregnancyandmultiplesclerosisanupdateonthediseasemodifyingtreatmentstrategyandareviewofpregnancysimpactondiseaseactivity AT dianaramasauskaite pregnancyandmultiplesclerosisanupdateonthediseasemodifyingtreatmentstrategyandareviewofpregnancysimpactondiseaseactivity AT dalialauzikiene pregnancyandmultiplesclerosisanupdateonthediseasemodifyingtreatmentstrategyandareviewofpregnancysimpactondiseaseactivity AT audronearlauskiene pregnancyandmultiplesclerosisanupdateonthediseasemodifyingtreatmentstrategyandareviewofpregnancysimpactondiseaseactivity |