Long-term outcomes and quality of life of patients with Hirschsprung disease: a systematic review and meta-analysis
Abstract Background Advances in surgical techniques and perioperative care have improved the short- and mid-term postoperative outcomes of patients with Hirschsprung disease (HD). However, the long-term outcomes of these patients (older than 10 years) have not been fully investigated. The aim of thi...
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| Format: | Article |
| Language: | English |
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BMC
2020-03-01
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| Series: | BMC Gastroenterology |
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| Online Access: | http://link.springer.com/article/10.1186/s12876-020-01208-z |
| _version_ | 1828193870212497408 |
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| author | Ying Dai Yongfang Deng Yan Lin Runxian Ouyang Le Li |
| author_facet | Ying Dai Yongfang Deng Yan Lin Runxian Ouyang Le Li |
| author_sort | Ying Dai |
| collection | DOAJ |
| description | Abstract Background Advances in surgical techniques and perioperative care have improved the short- and mid-term postoperative outcomes of patients with Hirschsprung disease (HD). However, the long-term outcomes of these patients (older than 10 years) have not been fully investigated. The aim of this systematic review is to clarify the prevalence of long-term outcomes and the quality of life of these patients. Methods PubMed, AMED, Cochrane Library, CINAHL and PsycINFO databases were searched from inception to October 2018, following the Meta-analysis of Observational Studies in Epidemiology (MOOSE) guideline. Original studies reporting the outcomes of patients older than ten years with HD were selected and reviewed. The overall prevalence of fecal incontinence, constipation, bowel function score, bladder dysfunction symptoms, and patients’ quality of life were extracted from the included studies and pooled through the random-effects meta-analysis model. The heterogeneity and variation in the pooled estimations were evaluated by Cochrane’s Q test and the I2 test. The sensitivity analysis was conducted by the sequential omission of individual studies. Publication bias was evaluated by Egger’s linear regression test. The whole procedure was conducted with Stata (version 14). Results In total, 3406 articles were identified from the literature search, among which twelve studies, including 625 patients, were included for analysis. The pooled prevalences of fecal incontinence, constipation, and bladder dysfunction symptoms and good to excellent bowel function scores were 0.20 (95% CI 0.13–0.28), 0.14 (95% CI 0.06–0.25), 0.07 (95% CI 0.04–0.12), and 0.95 (95% CI: 0.91–0.97), respectively; the pooled mean score of gastrointestinal-related quality of life was 118 (95% CI: 112.56–123.44). Conclusions HD patients older than ten years old have an overall high prevalence of fecal incontinence and a low quality of life. Targeted and evidence-based follow-up procedures and transitional care are essential to meet these patients’ long-term care needs. Prospective and multicenter research that focuses on the attributes and predictors of the long-term prognosis of patients with HD are necessary. |
| first_indexed | 2024-04-12T09:15:58Z |
| format | Article |
| id | doaj.art-5202a465809e499482351f020f6a86f5 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-04-12T09:15:58Z |
| publishDate | 2020-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-5202a465809e499482351f020f6a86f52022-12-22T03:38:50ZengBMCBMC Gastroenterology1471-230X2020-03-0120111310.1186/s12876-020-01208-zLong-term outcomes and quality of life of patients with Hirschsprung disease: a systematic review and meta-analysisYing Dai0Yongfang Deng1Yan Lin2Runxian Ouyang3Le Li4Department of Pediatric Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou Medical UniversityDepartment of Obstetrics and Gynecology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical UniversityDepartment of Nursing, Guangzhou Women and Children’s Medical Center, Guangzhou Medical UniversityDepartment of Pediatric Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou Medical UniversityDepartment of Pediatric Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou Medical UniversityAbstract Background Advances in surgical techniques and perioperative care have improved the short- and mid-term postoperative outcomes of patients with Hirschsprung disease (HD). However, the long-term outcomes of these patients (older than 10 years) have not been fully investigated. The aim of this systematic review is to clarify the prevalence of long-term outcomes and the quality of life of these patients. Methods PubMed, AMED, Cochrane Library, CINAHL and PsycINFO databases were searched from inception to October 2018, following the Meta-analysis of Observational Studies in Epidemiology (MOOSE) guideline. Original studies reporting the outcomes of patients older than ten years with HD were selected and reviewed. The overall prevalence of fecal incontinence, constipation, bowel function score, bladder dysfunction symptoms, and patients’ quality of life were extracted from the included studies and pooled through the random-effects meta-analysis model. The heterogeneity and variation in the pooled estimations were evaluated by Cochrane’s Q test and the I2 test. The sensitivity analysis was conducted by the sequential omission of individual studies. Publication bias was evaluated by Egger’s linear regression test. The whole procedure was conducted with Stata (version 14). Results In total, 3406 articles were identified from the literature search, among which twelve studies, including 625 patients, were included for analysis. The pooled prevalences of fecal incontinence, constipation, and bladder dysfunction symptoms and good to excellent bowel function scores were 0.20 (95% CI 0.13–0.28), 0.14 (95% CI 0.06–0.25), 0.07 (95% CI 0.04–0.12), and 0.95 (95% CI: 0.91–0.97), respectively; the pooled mean score of gastrointestinal-related quality of life was 118 (95% CI: 112.56–123.44). Conclusions HD patients older than ten years old have an overall high prevalence of fecal incontinence and a low quality of life. Targeted and evidence-based follow-up procedures and transitional care are essential to meet these patients’ long-term care needs. Prospective and multicenter research that focuses on the attributes and predictors of the long-term prognosis of patients with HD are necessary.http://link.springer.com/article/10.1186/s12876-020-01208-zChildrenConstipationFollow-upFecal incontinenceHirschsprung diseaseLong-term outcome |
| spellingShingle | Ying Dai Yongfang Deng Yan Lin Runxian Ouyang Le Li Long-term outcomes and quality of life of patients with Hirschsprung disease: a systematic review and meta-analysis BMC Gastroenterology Children Constipation Follow-up Fecal incontinence Hirschsprung disease Long-term outcome |
| title | Long-term outcomes and quality of life of patients with Hirschsprung disease: a systematic review and meta-analysis |
| title_full | Long-term outcomes and quality of life of patients with Hirschsprung disease: a systematic review and meta-analysis |
| title_fullStr | Long-term outcomes and quality of life of patients with Hirschsprung disease: a systematic review and meta-analysis |
| title_full_unstemmed | Long-term outcomes and quality of life of patients with Hirschsprung disease: a systematic review and meta-analysis |
| title_short | Long-term outcomes and quality of life of patients with Hirschsprung disease: a systematic review and meta-analysis |
| title_sort | long term outcomes and quality of life of patients with hirschsprung disease a systematic review and meta analysis |
| topic | Children Constipation Follow-up Fecal incontinence Hirschsprung disease Long-term outcome |
| url | http://link.springer.com/article/10.1186/s12876-020-01208-z |
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