Microfluidic Chip with Low Constant-Current Stimulation (LCCS) Platform: Human Nucleus Pulposus Degeneration In Vitro Model for Symptomatic Intervertebral Disc

Microfluidic Chip with Low Constant-Current Stimulation (LCCS) Platform: Human Nucleus Pulposus Degeneration In Vitro Model for Symptomatic Intervertebral Disc

Intervertebral disc (IVD) degeneration is a major cause of low back pain (LBP) in the lumbar spine. This phenomenon is caused by several processes, including matrix degradation in IVD tissues, which is mediated by matrix metalloproteinases (MMPs) and inflammatory responses, which can be mediated by...

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Bibliographic Details
Main Authors: An-Gi Kim, Tae-Won Kim, Woo-Keun Kwon, Kwang-Ho Lee, Sehoon Jeong, Min-Ho Hwang, Hyuk Choi
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Micromachines
Subjects:
microfluidic chip
electrical stimulation
low constant-current stimulation
intervertebral disc degeneration
inflammation
Online Access:https://www.mdpi.com/2072-666X/12/11/1291

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