Pyridoxamine Limits Cardiac Dysfunction in a Rat Model of Doxorubicin-Induced Cardiotoxicity

Pyridoxamine Limits Cardiac Dysfunction in a Rat Model of Doxorubicin-Induced Cardiotoxicity

The use of doxorubicin (DOX) chemotherapy is restricted due to dose-dependent cardiotoxicity. Pyridoxamine (PM) is a vitamin B6 derivative with favorable effects on diverse cardiovascular diseases, suggesting a cardioprotective effect on DOX-induced cardiotoxicity. The cardioprotective nature of PM...

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Bibliographic Details
Main Authors: Sibren Haesen, Manon Marie Jager, Aline Brillouet, Iris de Laat, Lotte Vastmans, Eline Verghote, Anouk Delaet, Sarah D’Haese, Ibrahim Hamad, Markus Kleinewietfeld, Jeroen Mebis, Wilfried Mullens, Ivo Lambrichts, Esther Wolfs, Dorien Deluyker, Virginie Bito
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Antioxidants
Subjects:
anthracyclines
cardiotoxicity
pyridoxamine
cardioprotection
preclinical study
inflammation
Online Access:https://www.mdpi.com/2076-3921/13/1/112

Internet

https://www.mdpi.com/2076-3921/13/1/112

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