Investigation of metal–flavonoid chelates and the determination of flavonoids via metal–flavonoid complexing reactions
Flavonoids constitute a large group of polyphenolic phytochemicals with antioxidant properties which are overwhelmingly exerted through direct free radical scavenging. Flavonoids also exhibit antioxidant properties through chelating with transition metals, primarily Fe(II), Fe(III) and Cu(II), which...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Serbian Chemical Society
2007-10-01
|
| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.shd.org.yu/JSCS/Vol72/No10/JSCS_V72_No10-01.pdf |
| _version_ | 1818385362551046144 |
|---|---|
| author | DUSAN MALESEV VESNA KUNTIC |
| author_facet | DUSAN MALESEV VESNA KUNTIC |
| author_sort | DUSAN MALESEV |
| collection | DOAJ |
| description | Flavonoids constitute a large group of polyphenolic phytochemicals with antioxidant properties which are overwhelmingly exerted through direct free radical scavenging. Flavonoids also exhibit antioxidant properties through chelating with transition metals, primarily Fe(II), Fe(III) and Cu(II), which participate in reactions generating free radicals. Metal–flavonoid chelates are considerably more potent free radical scavengers than the parent flavonoids and play a prominent role in protecting from oxidative stress. To unravel the origin of their potent biological action extensive physico–chemical studies were undertaken to reveal the chemical structure, chelation sites, assess the impact of the metal/ligand ratio on the structure of the complexes and the capacity of flavonoids to bind metal ions. In spite of such extensive efforts, data on the composition, structure and complex-formation properties are incomplete and sometimes even contradictory. The aim of this paper is to give a personal account on the development of the field through a retrospective evaluation of our own research which covers approximately 40 complexes of flavonoids from different flavonoids subclasses (rutin, quercetin, 3-hydroxyflavone, morin and hesperidin) with several metal ions or groups and suggest directions for future research. Special emphasis will be given to the site of the central ion, the composition of the complexes, the role of pH in complex formation, the stability of metal–flavonoid complexes and their potential application for analytical purposes. |
| first_indexed | 2024-12-14T03:36:57Z |
| format | Article |
| id | doaj.art-52044c2d1bf14bfaa0e825944b1a69c3 |
| institution | Directory Open Access Journal |
| issn | 0352-5139 |
| language | English |
| last_indexed | 2024-12-14T03:36:57Z |
| publishDate | 2007-10-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-52044c2d1bf14bfaa0e825944b1a69c32022-12-21T23:18:36ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51392007-10-017210921939Investigation of metal–flavonoid chelates and the determination of flavonoids via metal–flavonoid complexing reactionsDUSAN MALESEVVESNA KUNTICFlavonoids constitute a large group of polyphenolic phytochemicals with antioxidant properties which are overwhelmingly exerted through direct free radical scavenging. Flavonoids also exhibit antioxidant properties through chelating with transition metals, primarily Fe(II), Fe(III) and Cu(II), which participate in reactions generating free radicals. Metal–flavonoid chelates are considerably more potent free radical scavengers than the parent flavonoids and play a prominent role in protecting from oxidative stress. To unravel the origin of their potent biological action extensive physico–chemical studies were undertaken to reveal the chemical structure, chelation sites, assess the impact of the metal/ligand ratio on the structure of the complexes and the capacity of flavonoids to bind metal ions. In spite of such extensive efforts, data on the composition, structure and complex-formation properties are incomplete and sometimes even contradictory. The aim of this paper is to give a personal account on the development of the field through a retrospective evaluation of our own research which covers approximately 40 complexes of flavonoids from different flavonoids subclasses (rutin, quercetin, 3-hydroxyflavone, morin and hesperidin) with several metal ions or groups and suggest directions for future research. Special emphasis will be given to the site of the central ion, the composition of the complexes, the role of pH in complex formation, the stability of metal–flavonoid complexes and their potential application for analytical purposes.http://www.shd.org.yu/JSCS/Vol72/No10/JSCS_V72_No10-01.pdfflavonoidschelatesfree radical scavengersstability constantsquantitative analysis |
| spellingShingle | DUSAN MALESEV VESNA KUNTIC Investigation of metal–flavonoid chelates and the determination of flavonoids via metal–flavonoid complexing reactions Journal of the Serbian Chemical Society flavonoids chelates free radical scavengers stability constants quantitative analysis |
| title | Investigation of metal–flavonoid chelates and the determination of flavonoids via metal–flavonoid complexing reactions |
| title_full | Investigation of metal–flavonoid chelates and the determination of flavonoids via metal–flavonoid complexing reactions |
| title_fullStr | Investigation of metal–flavonoid chelates and the determination of flavonoids via metal–flavonoid complexing reactions |
| title_full_unstemmed | Investigation of metal–flavonoid chelates and the determination of flavonoids via metal–flavonoid complexing reactions |
| title_short | Investigation of metal–flavonoid chelates and the determination of flavonoids via metal–flavonoid complexing reactions |
| title_sort | investigation of metal flavonoid chelates and the determination of flavonoids via metal flavonoid complexing reactions |
| topic | flavonoids chelates free radical scavengers stability constants quantitative analysis |
| url | http://www.shd.org.yu/JSCS/Vol72/No10/JSCS_V72_No10-01.pdf |
| work_keys_str_mv | AT dusanmalesev investigationofmetalflavonoidchelatesandthedeterminationofflavonoidsviametalflavonoidcomplexingreactions AT vesnakuntic investigationofmetalflavonoidchelatesandthedeterminationofflavonoidsviametalflavonoidcomplexingreactions |