Biocompatibility of a Ti-Rich Medium-Entropy Alloy with Glioblastoma Astrocytoma Cells
Titanium and titanium alloys are widely used in medical devices and implants; thus, the biocompatibility of these metals is of great importance. In this study, glioblastoma astrocytoma cellular responses to Ti<sub>65</sub>-Zr<sub>18</sub>-Nb<sub>16</sub>-Mo<sub...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/23/14552 |
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| author | Wen-Fu Ho Ka-Kin Wong Mei-Hwa Lee James L. Thomas Ya-Chun Chang Shih-Ching Wu Hsueh-Chuan Hsu Hung-Yin Lin |
| author_facet | Wen-Fu Ho Ka-Kin Wong Mei-Hwa Lee James L. Thomas Ya-Chun Chang Shih-Ching Wu Hsueh-Chuan Hsu Hung-Yin Lin |
| author_sort | Wen-Fu Ho |
| collection | DOAJ |
| description | Titanium and titanium alloys are widely used in medical devices and implants; thus, the biocompatibility of these metals is of great importance. In this study, glioblastoma astrocytoma cellular responses to Ti<sub>65</sub>-Zr<sub>18</sub>-Nb<sub>16</sub>-Mo<sub>1</sub> (Ti65M, metastable medium-entropy alloy), Ti-13Nb-7Sn-4Mo (TNSM, titanium alloy), and commercially pure titanium (CP-Ti) were studied. Several physical parameters (crystal phase structure, surface roughness and hardness) of the titanium alloys were measured, and the correlation with the cellular viability was investigated. Finally, the relative protein expression in cellular proliferation pathways was measured and compared with mRNA expression assessed with quantitative real-time reverse transcription polymerase chain reaction assay (qRT-PCR). |
| first_indexed | 2024-03-09T17:47:23Z |
| format | Article |
| id | doaj.art-5205bf5e46344adba4360b0d02703e87 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T17:47:23Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5205bf5e46344adba4360b0d02703e872023-11-24T11:03:53ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123231455210.3390/ijms232314552Biocompatibility of a Ti-Rich Medium-Entropy Alloy with Glioblastoma Astrocytoma CellsWen-Fu Ho0Ka-Kin Wong1Mei-Hwa Lee2James L. Thomas3Ya-Chun Chang4Shih-Ching Wu5Hsueh-Chuan Hsu6Hung-Yin Lin7Department of Chemical and Materials Engineering, National University of Kaohsiung, Kaohsiung 81148, TaiwanDepartment of Chemical and Materials Engineering, National University of Kaohsiung, Kaohsiung 81148, TaiwanDepartment of Materials Science and Engineering, I-Shou University, Kaohsiung 84001, TaiwanDepartment of Physics and Astronomy, University of New Mexico, Albuquerque, NM 87131, USADepartment of Chemical and Materials Engineering, National University of Kaohsiung, Kaohsiung 81148, TaiwanDepartment of Dental Technology and Materials Science, Central Taiwan University of Science and Technology, Taichung 40601, TaiwanDepartment of Dental Technology and Materials Science, Central Taiwan University of Science and Technology, Taichung 40601, TaiwanDepartment of Chemical and Materials Engineering, National University of Kaohsiung, Kaohsiung 81148, TaiwanTitanium and titanium alloys are widely used in medical devices and implants; thus, the biocompatibility of these metals is of great importance. In this study, glioblastoma astrocytoma cellular responses to Ti<sub>65</sub>-Zr<sub>18</sub>-Nb<sub>16</sub>-Mo<sub>1</sub> (Ti65M, metastable medium-entropy alloy), Ti-13Nb-7Sn-4Mo (TNSM, titanium alloy), and commercially pure titanium (CP-Ti) were studied. Several physical parameters (crystal phase structure, surface roughness and hardness) of the titanium alloys were measured, and the correlation with the cellular viability was investigated. Finally, the relative protein expression in cellular proliferation pathways was measured and compared with mRNA expression assessed with quantitative real-time reverse transcription polymerase chain reaction assay (qRT-PCR).https://www.mdpi.com/1422-0067/23/23/14552Ti-rich medium-entropy alloycell viabilityglioblastoma astrocytoma cell |
| spellingShingle | Wen-Fu Ho Ka-Kin Wong Mei-Hwa Lee James L. Thomas Ya-Chun Chang Shih-Ching Wu Hsueh-Chuan Hsu Hung-Yin Lin Biocompatibility of a Ti-Rich Medium-Entropy Alloy with Glioblastoma Astrocytoma Cells International Journal of Molecular Sciences Ti-rich medium-entropy alloy cell viability glioblastoma astrocytoma cell |
| title | Biocompatibility of a Ti-Rich Medium-Entropy Alloy with Glioblastoma Astrocytoma Cells |
| title_full | Biocompatibility of a Ti-Rich Medium-Entropy Alloy with Glioblastoma Astrocytoma Cells |
| title_fullStr | Biocompatibility of a Ti-Rich Medium-Entropy Alloy with Glioblastoma Astrocytoma Cells |
| title_full_unstemmed | Biocompatibility of a Ti-Rich Medium-Entropy Alloy with Glioblastoma Astrocytoma Cells |
| title_short | Biocompatibility of a Ti-Rich Medium-Entropy Alloy with Glioblastoma Astrocytoma Cells |
| title_sort | biocompatibility of a ti rich medium entropy alloy with glioblastoma astrocytoma cells |
| topic | Ti-rich medium-entropy alloy cell viability glioblastoma astrocytoma cell |
| url | https://www.mdpi.com/1422-0067/23/23/14552 |
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