Antimicrobial peptides in Echinoderms
Antimicrobial peptides (AMPs) are important immune effector molecules for invertebrates, including echinoderms, which lack a vertebrate-type adaptive immune system. Here we summarize the knowledge of such peptides in echinoderms. Strongylocins are a novel family of cysteine-rich AMPs, recently ident...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
University of Modena and Reggio Emilia
2010-05-01
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| Series: | Invertebrate Survival Journal |
| Subjects: | |
| Online Access: | http://www.isj.unimo.it/articoli/ISJ208.pdf |
| _version_ | 1818211588185784320 |
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| author | C Li T Haug K Stensvåg |
| author_facet | C Li T Haug K Stensvåg |
| author_sort | C Li |
| collection | DOAJ |
| description | Antimicrobial peptides (AMPs) are important immune effector molecules for invertebrates, including echinoderms, which lack a vertebrate-type adaptive immune system. Here we summarize the knowledge of such peptides in echinoderms. Strongylocins are a novel family of cysteine-rich AMPs, recently identified in the sea urchins, Strongylocentrotus droebachiensis and S. purpuratus. Although these molecules present diverse amino acid sequences, they share an identical cysteine arrangement pattern, dissimilar to other known AMPs. A family of heterodimeric AMPs, named centrocins, are also present in S. droebachiensis. Lysozymes and fragments of larger proteins, such as beta-thymocins, actin, histone 2A and filamin A have also been shown to display antimicrobial activities in echinoderms. Future studies on AMPs should be aimed in revealing how echinoderms use these AMPs in the immune response against microbial pathogens. |
| first_indexed | 2024-12-12T05:34:53Z |
| format | Article |
| id | doaj.art-52078933b01e4978bc16947981224f1d |
| institution | Directory Open Access Journal |
| issn | 1824-307X |
| language | English |
| last_indexed | 2024-12-12T05:34:53Z |
| publishDate | 2010-05-01 |
| publisher | University of Modena and Reggio Emilia |
| record_format | Article |
| series | Invertebrate Survival Journal |
| spelling | doaj.art-52078933b01e4978bc16947981224f1d2022-12-22T00:36:11ZengUniversity of Modena and Reggio EmiliaInvertebrate Survival Journal1824-307X2010-05-0171132140Antimicrobial peptides in EchinodermsC LiT HaugK StensvågAntimicrobial peptides (AMPs) are important immune effector molecules for invertebrates, including echinoderms, which lack a vertebrate-type adaptive immune system. Here we summarize the knowledge of such peptides in echinoderms. Strongylocins are a novel family of cysteine-rich AMPs, recently identified in the sea urchins, Strongylocentrotus droebachiensis and S. purpuratus. Although these molecules present diverse amino acid sequences, they share an identical cysteine arrangement pattern, dissimilar to other known AMPs. A family of heterodimeric AMPs, named centrocins, are also present in S. droebachiensis. Lysozymes and fragments of larger proteins, such as beta-thymocins, actin, histone 2A and filamin A have also been shown to display antimicrobial activities in echinoderms. Future studies on AMPs should be aimed in revealing how echinoderms use these AMPs in the immune response against microbial pathogens.http://www.isj.unimo.it/articoli/ISJ208.pdfsea urchinhost defence peptidescelomocyteinnate immunity |
| spellingShingle | C Li T Haug K Stensvåg Antimicrobial peptides in Echinoderms Invertebrate Survival Journal sea urchin host defence peptides celomocyte innate immunity |
| title | Antimicrobial peptides in Echinoderms |
| title_full | Antimicrobial peptides in Echinoderms |
| title_fullStr | Antimicrobial peptides in Echinoderms |
| title_full_unstemmed | Antimicrobial peptides in Echinoderms |
| title_short | Antimicrobial peptides in Echinoderms |
| title_sort | antimicrobial peptides in echinoderms |
| topic | sea urchin host defence peptides celomocyte innate immunity |
| url | http://www.isj.unimo.it/articoli/ISJ208.pdf |
| work_keys_str_mv | AT cli antimicrobialpeptidesinechinoderms AT thaug antimicrobialpeptidesinechinoderms AT kstensvag antimicrobialpeptidesinechinoderms |