<i>Mycobacterium vaccae</i> Adaptation to Disinfectants and Hand Sanitisers, and Evaluation of Cross-Tolerance with Antimicrobials
<i>Mycobacterium vaccae</i> is being considered as an adjuvant to antituberculosis therapy, tested for the treatment of autoimmune diseases, and as an anti-depressive agent. This bacterium is ubiquitous in the environment and the widespread use of disinfectants and sanitisers may lead to...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/9/9/544 |
| _version_ | 1797555391615205376 |
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| author | Carla C. C. R. de Carvalho Raquel Teixeira Pedro Fernandes |
| author_facet | Carla C. C. R. de Carvalho Raquel Teixeira Pedro Fernandes |
| author_sort | Carla C. C. R. de Carvalho |
| collection | DOAJ |
| description | <i>Mycobacterium vaccae</i> is being considered as an adjuvant to antituberculosis therapy, tested for the treatment of autoimmune diseases, and as an anti-depressive agent. This bacterium is ubiquitous in the environment and the widespread use of disinfectants and sanitisers may lead to its adaptation to these compounds. In the present study, <i>M. vaccae</i> cells adapted to these compounds mainly by making adjustments in their lipid composition and net surface charge. The modifications in the lipid composition led to changes in membrane permeability which resulted in increased tolerance towards levofloxacin, thioridazine, and omeprazole. |
| first_indexed | 2024-03-10T16:46:49Z |
| format | Article |
| id | doaj.art-5207f2ab2adb4cd6a6e0c1c90839c19c |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T16:46:49Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-5207f2ab2adb4cd6a6e0c1c90839c19c2023-11-20T11:32:16ZengMDPI AGAntibiotics2079-63822020-08-019954410.3390/antibiotics9090544<i>Mycobacterium vaccae</i> Adaptation to Disinfectants and Hand Sanitisers, and Evaluation of Cross-Tolerance with AntimicrobialsCarla C. C. R. de Carvalho0Raquel Teixeira1Pedro Fernandes2Department of Bioengineering, iBB–Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, PortugalDepartment of Bioengineering, iBB–Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, PortugalDepartment of Bioengineering, iBB–Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, Portugal<i>Mycobacterium vaccae</i> is being considered as an adjuvant to antituberculosis therapy, tested for the treatment of autoimmune diseases, and as an anti-depressive agent. This bacterium is ubiquitous in the environment and the widespread use of disinfectants and sanitisers may lead to its adaptation to these compounds. In the present study, <i>M. vaccae</i> cells adapted to these compounds mainly by making adjustments in their lipid composition and net surface charge. The modifications in the lipid composition led to changes in membrane permeability which resulted in increased tolerance towards levofloxacin, thioridazine, and omeprazole.https://www.mdpi.com/2079-6382/9/9/544antibioticlevofloxacinteicoplaninefflux pumpthioridazineomeprazole |
| spellingShingle | Carla C. C. R. de Carvalho Raquel Teixeira Pedro Fernandes <i>Mycobacterium vaccae</i> Adaptation to Disinfectants and Hand Sanitisers, and Evaluation of Cross-Tolerance with Antimicrobials Antibiotics antibiotic levofloxacin teicoplanin efflux pump thioridazine omeprazole |
| title | <i>Mycobacterium vaccae</i> Adaptation to Disinfectants and Hand Sanitisers, and Evaluation of Cross-Tolerance with Antimicrobials |
| title_full | <i>Mycobacterium vaccae</i> Adaptation to Disinfectants and Hand Sanitisers, and Evaluation of Cross-Tolerance with Antimicrobials |
| title_fullStr | <i>Mycobacterium vaccae</i> Adaptation to Disinfectants and Hand Sanitisers, and Evaluation of Cross-Tolerance with Antimicrobials |
| title_full_unstemmed | <i>Mycobacterium vaccae</i> Adaptation to Disinfectants and Hand Sanitisers, and Evaluation of Cross-Tolerance with Antimicrobials |
| title_short | <i>Mycobacterium vaccae</i> Adaptation to Disinfectants and Hand Sanitisers, and Evaluation of Cross-Tolerance with Antimicrobials |
| title_sort | i mycobacterium vaccae i adaptation to disinfectants and hand sanitisers and evaluation of cross tolerance with antimicrobials |
| topic | antibiotic levofloxacin teicoplanin efflux pump thioridazine omeprazole |
| url | https://www.mdpi.com/2079-6382/9/9/544 |
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